Herbicidal sulfonamides

ABSTRACT

This invention relates to certain sulfonylurea compounds having substituents ortho to the sulfonyl-urea linkage that includes a 3- or 4-membered carbocyclic ring, a saturated 5- or 6-membered carbocyclic ring of a heterocyclic ring which contains 1 hetero-atom selected from O, S and NR 3 , agriculturally suitable compositions thereof and a method of their use as herbicides or plant growth regulants.

BACKGROUND OF THE INVENTION

This invention relates to herbicidally active sulfonylurea compounds, agriculturally suitable compositions containing them and their method of use as herbicides or plant growth regulants.

In the most common situation, the control of undesired vegetation is desired to permit the growth of useful crops such as cotton, rice, corn, wheat and soybeans, to name a few. Unchecked weed growth in such useful crops can cause significant losses, reducing profit to the farmer and increasing costs to the consumer. In other situations, herbicides are desired which will control all plant growth. Examples of areas in which complete control of all vegetation is desired are areas around fuel storage tanks, ammunition depots and industrial storage areas. There are many products commercially available for these purposes, but the search continues for products which are more effective, less costly and environmentally safe.

European Patent Application (EP-A) No. 83,975, published July 20, 1983, discloses herbicidal benzene-sulfonamides of formula ##STR1## wherein Q is selected from various five or six-membered aromatic or partially unsaturated heterocyclic rings containing 2 or 3 heteroatoms selected from O, S or NR.

U.S. Pat. No. 4,368,069 discloses herbicidal benzenesulfonamides of formula ##STR2## wherein R is --(CR₅ R₆)_(n) --R₂ ;

n is 0 or 1; and

R₂ may be C₂ -C₅ alkenyl, C₅ -C₆ cycloalkenyl or C₂ -C₃ alkenyl substituted with 1-3 chlorine atoms.

European Patent Application (EP-A) No. 85,476, published Aug. 10, 1983, discloses herbicidal benzenesulfonamides of formulae ##STR3## wherein Q is selected from various 5-membered aromatic heterocycles, and their dihydro and tetrahydro analogs, which contain one heteroatom selected from O, S or NR, or Q is a saturated or partially unsaturated 6-membered ring containing one heteroatom selected from O or S: and

Q¹ is a 6-membered aromatic heterocycle containing one to three N atoms.

South African Patent Application No. 83/8416, published May, 1984, discloses herbicidal benzene-sulfonamides of formula ##STR4## wherein A is an unsaturated or only partially saturated 5- or 6-membered heterocyclic ring system which is bonded through a carbon atom and contains 1, 2 or 3 heteroatoms.

Herbicidal thiophene sulfonamides are disclosed in European Patent Application (EP-A) Nos. 30,142, published June 10, 1981, and 97,122, published Dec. 28, 1983, and in U.S. Pat. Nos. 4,127,405, 4,169,719, 4,398,939 and 4,441,910.

EP-A- No.95,925, published Dec. 7, 1983, discloses herbicidal pyrazolesulfonamides in which the group adjacent to the sulfonamide moiety may be selected from H, C₁ -C₃ alkyl, F, Cl, Br, NO₂, OR₁₆, CO₂ R₂₃, S(O)_(n) R₂₄ or SO₂ NR₁₉ R₂₀.

Ep-A- No.87,780, published Sep. 7, 1983 discloses pyrazole sulfonamides of general formula ##STR5## wherein A is H, C₁ -C₈ alkyl or optionally substituted phenyl;

B and C are independently H, halogen, NO₂, C₁ -C₈ alkyl, CO₂ R, etc.; and

D is H or C₁ -C₈ alkyl.

EP-A- No.96,003, published Nov. 28, 1983, discloses herbicidal compounds of general formula ##STR6## wherein R₁ is H or C₁ -C₃ alkyl; and

Q is an unsubstituted or substituted five-membered heterocyclic radical which is bound by way of a carbon atom and which contains 2 or 3 identical or different heteroatoms.

Herbicidal pyridinesulfonamides are disclosed in European Patent Application (EP-A) Nos. 13,480 published July 23, 1980, 35,893 published Sept. 16, 1981, 16,1981, 97,122 published Dec. 28, 1983 and 103,543 published Mar. 21, 1984 and in U.S. Pat. No. 4.435.206.

U.S. Pat. No. 4,420,325 discloses herbicidal sulfonamides of the following formula ##STR7## wherein R₁ is F, Cl, Br, CF₃, C₁ -C₃ alkoxy, C₁ -C₃ alkyl, NO₂, CO₂ R₄, SO₂ R₅, SO₂ NR₆ R₇, SO₂ N(OCH₃)CH₃, SO₂ OCH₂ CF₃, OSO₂ R₅ or CH₂ L;

R₂ is H, Cl, Br, F, CF₃ or OCH₃ ;

R₉ is H or C₁ -C₃ alkyl; etc.

SUMMARY OF THE INVENTION

This invention is the discovery of new compounds with herbicidal activity, agriculturally suitable compositions thereof and a method of using said compounds as general or selective preemergent and/or post emergent herbicides. Accordingly the new compounds of the invention are compounds of the formula ##STR8## wherein W is O or S;

R is H or CH₃ ;

L is ##STR9## n is 0 or 1; R₁ is H, C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, halogen, nitro, CN, C₁ -C₃ alkoxy, SO₂ NR^(I) R^(II), C₁ -C₃ alkylthio, C₁ -C₃ alkylsulfinyl, C₁ -C₃ alkylsulfonyl, CO₂ R^(III), CH₂ CN, CH₂ OCH₃ or CH₂ SCH₃ ;

R^(I) is H, C₁ -C₄ alkyl, C₂ -C₃ cyanoalkyl, methoxy or ethoxy;

R^(II) is H, C₁ -C₄ alkyl or C₃ -C₄ alkenyl; or

R^(I) and R^(II) may be taken together as --(CH₂)₃ --, --(CH₂)₄ --, --(CH₂)₅ -- or --CH₂ CH₂ OCH₂ CH₂ --;

R^(III) is C₁ -C₄ alkyl, C₃ -C₄ alkenyl, C₃ -C₄ alkynyl, C₂ -C₄ haloalkyl, C₂ -C₃ cyanoalkyl, C₅ --C₆ cycloalkyl, C₄ -C₇ cycloalkylalkyl or C₂ -C₄ alkoxyalkyl;

R₂ is C₁ -C₃ alkyl;

Q is a 3- or 4-membered heterocyclic ring which contains one heteroatom selected from O, S and NR₃ or a 3- or 4-membered carbocyclic ring in which one carbon atom may optionally be in the form of a carbonyl group, or a fully-saturated 5- or 6-membered carbocyclic ring, and Q may be optionally substituted with 1-4 substituents selected from halogen, CN, OH, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, C₁ -C₃ alkylthio, C₂ -C₄ alkoxycarbonyl, C₁ -C₄ alkylsulfonyl. (C₁ -C₄ alkyl)aminosulfamoyl and di(C₁ -C₄ alkyl)aminosulfamoyl:

R₃ is C₁ -C₄ alkyl;

R₁₂ is H or OR₁₄ ;

R₁₃ is H or C₁ -C₄ alkyl;

R₁₄ is H, C₁ -C₄ alkyl, C₃ -C₄ alkenyl, C₃ -C₄ haloalkenyl, C₃ -C₄ alkynyl, C₃ -C₄ haloalkynyl, C₂ -C₄ alkylcarbonyl, C(O)NR₁₅ R₁₆, C₁ -C₄ alkylsulfonyl, C₂ -C₄ alkoxyalkyl or C₂ -C₄ alkylthioalkyl:

R₁₅ and R₁₆ are independently H or C₁ -C₂ alkyl:

A is ##STR10## X is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkyl, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, halogen, C₂ -C₅ alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino or di(C₁ -C₃ alkyl)amino;

Y is H, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, C₂ -C₅ alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino, di(C₁ -C₃ alkyl)amino, C₃ -C₄ alkenyloxy, C₃ -C₄ alkynyloxy, C₂ -C₅ alkylthioalkyl, C₂ -C₅ alkylsulfinylalkyl, C₂ -C₅ alkylsulfonylalkyl, C₁ -C₄ haloalkyl, C₃ -C₅ cycloalkyl, C₂ -C₄ alkynyl, ##STR11## or N(OCH₃)CH₃ ; m is 2 or 3;

L₁ and L₂ are independently O or S;

R₄ and R₅ are independently C₁ -C₂ alkyl;

R₆ is H or CH₃ ;

Z is CH or N;

Y₁ is O or CH₂ ;

X₁ is CH₃, OCH₃, OC₂ H₅ or OCF₂ H;

Y₂ is H or CH₃ ;

X₂ is CH₃, OCH₃ or SCH₃ ;

Y₃ is CH₃, CH₂ CH₃ or CH₂ CF₃ ;

X₃ is CH₃ or OCH₃ ;

Y₄ is CH₃, OCH₃, OC₂ H₅ or Cl; and

X₄ is CH₃, OCH₃, OC₂ H₅ or CH₂ OCH₃ ; and their agriculturally suitable salts; provided that

(a) when X is Cl, F, Br or I, then Z is CH and Y is OCH₃, OC₂ H₅, N(OCH₃)CH₃, NHCH₃, N(CH₃)₂ or OCF₂ H;

(b) when X or Y is OCF₂ H, then Z is CH;

(c) when L is L-2 or L-3. then the Q substituent and the sulfonylurea bridge are on adjacent carbon atoms;

(d) when W is S, then R is H, A is A-1, and Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ .tbd.CH, OCH₂ CH₂ OCH₃ or CH(OCH₃)₂ ;

(e) the total number of carbon atoms of R₁₂ and R₁₃ must be less than or equal to four; and

(f) when the total number of carbon atoms of X and Y is greater than four, then the number of carbons of R₁ must be less than or equal to two and the number of carbons of Q must be less than or equal to six.

In the above definitions, the term "alkyl," used either alone or in compound words such as "alkylthio" or "haloalkyl," denotes straight chain or branched alkyl e.g. methyl, ethyl, n-propyl, isopropyl or the different butyl isomers.

Alkoxy denotes methoxy, ethoxy, n-propoxy, isopropoxy and the different butoxy isomers.

Alkenyl denotes straight chain or branched alkenes, e.g. vinyl, 1-propenyl, 2-propenyl, 3-propenyl and the different butenyl isomers.

Alkynyl denotes straight chain or branched alkynes, e.g. ethynyl, 1-propynyl, 2-propynyl and the different butynyl isomers.

Cycloalkyl denotes cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.

The term "halogen," either alone or in compound words such as "haloalkyl," denotes fluorine, chlorine, bromine and iodine.

In terms such as C₂ -C₃ alkylthioalkyl, the specified number of carbon atoms is meant to define the total number of carbon atoms in that substituent group. For example, C₂ -C₃ alkylthioalkyl would designate CH₂ CH₃, CH₂ SC₂ H₅, CH₂ CH₂ SCH₃ or CH(CH₃)SCH₃, and C₂ -C₅ alkoxyalkoxy would represent OCH₂ OCH₃ through O(CH₂)₄ OCH₃ or OCH₂ O(CH₂)₃ CH₃ and the various structural isomers embraced therein.

Alkoxycarbonyl denotes methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl and isopropoxycarbony.

Alkylcarbonyl denotes e.g. acetyl, propionyl, and the different butyryl isomers.

Alkylsulfonyl denotes methylsulfonyl, ethylsulfonyl and the different propylsulfonyl and butylsulfonyl isomers.

ALkylthio, alkylsulfinyl, alkylamino, alkylsulfamoyl etc. are defined in an analogous manner.

The compounds of the invention which are preferred for reasons of increased ease of synthesis and/or greater herbicidal efficacy are:

(1) Compounds of Formula I where Q is ##STR12## wherein R₃ is C₁ -C₃ alkyl;

R₇ is H, F, Cl, Br, CN, CH₃ or OCH₃ ;

R₈ is H, F, Cl, Br, I, CN, OH, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, C₂ -C₃ alkoxycarbonyl, di(C₁ -C₃ alkyl)aminosulfamoyl, C₁ -C₃ alkylthio or C₁ -C₃ alkylsulfonyl;

R₉ and R₁₀ are independently H, CH₃, F, Cl or may be taken together to form C═O; and

R₁₁ is H or C₁ -C₃ alkyl: provided that

(a) when R₇ and R₈ are attached to the same carbon atom as in Q-1, Q-2 or Q-3, or in Q-4 through Q-10, and R₇ is OCH₃, then R₈ is other than F, Cl, Br, I or OH; and

(b) when R₇ and R₈ are attached to the same carbon atom as in Q-1, Q-2 or Q-3, or in Q-4 through Q-10, and R₈ is F, Cl, Br, I or OH, then R₇ is other than OCH₃.

(2) Compounds of Preferred 1 where A is A-1, W is O; and R is H.

(3) Compounds of Preferred 2 where

R₁ is selected from H, F, Cl, NO₂, C₁ -C₂ alkyl, C₁ -C₂ haloalkyl, C₁ -C₂ alkoxy, C₁ -C₂ alkylthio, CH₂ OCH₃ or CH₂ SCH₃ ;

R₁₃ is H or CH₃ ;

R₁₄ is H, C₁ -C₂ alkyl, CH₂ CH═CH₂ or CH₂ C.tbd.CH;

X is CH₃, OCH₃, OC₂ H₅, Cl, F, Br, OCFhd 2H, CH₂ F, OCH₂ CH₂ F, OCH₂ CHF₂, OCH₂ CF₃, CF₃, CH₂ Cl or CH₂ Br; and

Y is H, C₁ -C₃ alkyl, OCH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, CH₂ OC₂ H₅, OCH₂ CH₂ OCH₃, CH₂ SCH₃, OCF₂ H, SCF₂ H, cyclopropyl, C.tbd.CH or C.tbd.CCH₃.

(4) Compounds of Preferred 3 where

L is L-1; and

Q is Q-1, Q-2 or Q-4.

(5) Compounds of Preferred 4 where Q is Q-1;

(6) Compounds of Preferred 5 where

R₁ is H, Cl, CH₃, OCH₃ or SCH₃ and is not in the 4-position;

R₇ is H, F, Cl, CH₃ or OCH₃ ;

R₈ is H, F, Cl, CH₃ or OCH₃ ; and

R₉ and R₁₀ are independently H, CH₃, F or Cl.

(7) Compounds of Preferred 3 where

L is L-2 or L-3; and

Q is Q-1, Q-2 or Q-4.

(8) Compounds of Preferred 7 where

R₁ is H;

R₇ is H, F, Cl, CH₃ or OCH₃ ;

R₈ is H, F, Cl, CH₃ or OCH₃ ;

R₉ and R₁₀ are independently H, CH₃, F or Cl; and

R₁₁ is H or CH₃.

(9) Compounds of Preferred 3 where

L is L-4 or L-5; and

Q is Q-1, Q-2 or Q-4.

(10) Compounds of Preferred 9 where

R₁ is H;

R₇ is H, F, Cl, CH₃ or OCH₃ ;

R₈ is H, F, Cl, CH₃ or OCH₃ ;

R₉ and R₁₀ are independently H, CH₃, F or Cl; and

R₁₁ is H or CH₃.

(11) Compounds of Preferred 3 where

L is L-6; and

Q is Q-1. Q-2 or Q-4.

(12) Compounds of Preferred 11 where

R₁ is H;

R₇ is H, F, Cl, CH₃ or OCH₃ ;

R₈ is H, F, Cl, CH₃ or OCH₃ ;

R₉ and R₁₀ are independently H, CH₃, F or Cl; and

R₁₁ is H or CH₃.

The compounds of the invention which are specifically preferred for reasons of their expected greatest ease of synthesis and/or greatest herbicidal efficacy are:

2-(2,2-dichlorocyclopropyl)-N-[(4.6-dimethoxypyrimidin-2-yl)aminocarbonyl]benzenesulfonamide, m.p. 193°-195° C.:

2-(2,2-dichlorocyclopropyl)-N-[(4-methoxy-6-methyl)aminocarbonyl]benzenesulfonamide, triazine-2-yl, m.p. 168°-170° C.; and

N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(2-oxiranylmethyl)benzenesulfonamide. m.p. 157°-159° C.(d).

DETAILED DESCRIPTION OF THE INVENTION Synthesis

The compounds of Formula I can be prepared by reacting an appropriate sulfonyl isocyanate or sulfonyl isothiocyanate, II, with an appropriately substituted aminoheterocycle, III, as shown in Equation 1, where R, W, A and L are as previously defined. ##STR13##

The reaction is best performed in an inert solvent such as methylene chloride or toluene at 25 to 100° C. for 1 to 24 hours. Isolation of the product can be achieved by concentrating the solution and trituration with an appropriate solvent such as butyl chloride.

Alternatively, compounds of Formula I, where W is O, can be prepared by reacting the sulfonamides of Formula IV with the carbamates of Formula V (R'=CH₃) in the presence of an excess of trimethylaluminum, as shown in Equation 2, where L, R and A are as previously defined, provided R₁ is other than CO₂ R^(III). ##STR14##

The reactions are best performed in an inert solvent such as methylene chloride at the reflux point of the solution (40° C.) for 10 to 24 hours. Isolation of the product is best achieved by exposing the reaction mixture to acetic acid, separation of the layers and concentrating the organic layer to a solid.

Alternatively, compounds of Formula I can be prepared by exposing a phenyl carbamate V (R'=Ph) to the sulfonamide IV in an appropriate solvent such as dioxane at 25° to 100° C. in the presence of a strong base such as 1,8-diazabicyclo[5.4.0]undec-7-ene; acid workup affords the desired product, as disclosed in European Patent Application (EP-A) No. 44,807. Compounds of Formula I can also be prepared from a phenyl carbamate V and the tert-butyldimethylsilyl-protected sulfonamide IV (LSO₂ NHSi(CH₃)₂ -t-Bu). Addition of tetrabutylammonium fluoride to a mixture of the carbamate and sulfonamide affords after workup the desired product. The required carbamates can be prepared from the corresponding amines, III, and dimethyl or diphenylcarbonate or methyl or phenylchloroformate and a base such as sodium hydride.

The sulfonyl isocyanates, II, used in the preparation of I are known in the art and can be prepared by known methods. For example, isocyanates can be prepared by exposing an appropriate benzene or heterocyclic sulfonamide to phosgene in the presence of an alkyl isocyanate and an amine catalyst such as 1,4-diazabicyclo[2.2.2]octane at the reflux point of the solvent; see H. Ulrich and A. A. Y. Sayigh, Newer Methods of Preparative Organic Chemistry, Vol. VI, p. 223-241, Academic Press, N.Y. and London, W. Forest Ed.

The sulfonyl isothiocyanates, II, used in the preparation of I, where W is S, can be prepared according to the procedure of K. Hartke, Arch. Pharm., 299, 174 (1966).

Sulfonamides of Formula L 1 (compound 3) where Q is Q-1, n=O, R₁, and R₇ through R₁₀ are as previously defined can be prepared in one or more of the ways outlined in Equations 3 through 7. ##STR15##

The addition of carbenes to styrene is well known in the art. For further details of such transformations see Keller. W. E., "Compendium of Phase-Transfer Reactions and Related Synthetic Methods", Fluka A. G., Switzerland, p 39-64, 1979. ##STR16##

An alternate sequence, outlined below in Equation 5, can be employed in selected cases where lithiation of 2 may be a problem due to functional group incompatibility with n-BuLi. (i.e., R₇ ═CO₂ CH₃). ##STR17##

The sulfonamide 3 can also be prepared by direct alkylation with the preformed cyclopropyl methyl halide 8 as outlined in Equation 6. ##STR18##

For further details pertaining to this modification of the Ullmann reaction see, S. Gronowitz, and S. Lilgefors, Chemica Scripta, 13, 157-161 (1978-79) and A. Minato, K. Tamo, T. Hayasi, K. Suzuki and M. Kumada; Tetrahedron Letters, 22, 5319 (1981).

In Equation 5 the dihaloethane 9 may be replaced with other electrophiles such as propylene oxide and its derivatives, as shown in Equation 7. ##STR19##

The ortho-lithiation of compounds such as 1, 2, 5 and 5a is well known to those skilled in the art. For further details pertaining to this type of transformation see Meyers, A. I., Michlich, B. D., and Nolan, R. L., J. Org. Chem., 39, 2783, 1974.

Sulfonamides of Formula L-1 (Compound 12) where n is 1 Q is Q-1 through Q-3 and R₁, R₃ and R₇ through R₁₃ are as previously defined can be prepared in a similar manner to that already described in Equations 3, 4 and 6, with slight modifications of the starting material. For example cyclopropanation of the styrene homolog 13, followed by ortho-lithiation chemistry would afford the target Compound 12 as outlined in Equation 8. ##STR20##

In an analogous manner to Equation 6, cyclopropane 12 can be prepared as outlined in Equation 9. ##STR21##

Alternatively, sulfonamide 12 can be prepared by a modified Ullmann reaction utilizing sulfonamide 5 as the starting material as outlined in Equation 10. ##STR22##

The epoxy sulfonamides of Formula L-1 (Compound 15) where Q is Q-2 and n, R₁, R₇, R₈ and R₁₁ are as previously defined can be prepared directly from olefins 1, 4 and 13 via epoxidation using m-chloroperbenzoic acid as described in Equation 11. ##STR23##

Further details pertaining to olefin epoxidations may be found in Org. Syn., Coll. Vol. 1, 494 (1944).

The aziridine sulfonamides where Q is Q-3 and n, R₁, R₃, R₇, R₈ and R₁₁ are as previously defined such as compound 16 can also be prepared from the corresponding olefins using the procedure outlined in Equation 12. ##STR24##

For further details see Gebelein, C. O., Swift, G., Swern, D., J. Org. Chem., 32. 3314 (1967).

Sulfonamides of Formula L-2, L-3, L-4, L-5 and L-6, where Q is Q-1 through Q-3 and n, R₁, R₂, R₃ and R₇ through R₁₁ are as previously defined can be prepared using one or more of the routes previously outlined in Equations 3 through 12.

For example, in the case of L-3. sulfonamide 18 can be prepared using the same route described in Equation 3 or 4. This is outlined in Equation 13. ##STR25##

Sulfonamides (such as 20) containing a four-membered ring where R₁, R₇ and R₈ are as previously defined may be prepared in one or more of the ways outlined in Equations 14 through 17b. ##STR26##

For a discussion of photochemical 2+2 cyclo-additions of styrene with olefins, aldehydes and ketones (the Paterno-Buchi reaction) see Silversmith, Kitahara, Caserio and Roberts, J. Am. Chem. Soc., 80, 5840 (1958).

An alternate synthesis of compounds such as 20 is via the anionic ring closure of chloride 25 as outlined in Equation 16. ##STR27##

In a similar manner the oxetane ring systems can be formed as shown in Equation 17a and 17b. ##STR28##

The methodology described in Equations 15, 17a and 17b can also be used to prepare the thio and amine analogs, that is sulfonamides of Formula L-1 where Q is Q-7 through Q-10 and R₁, R₃ l , R₇ and R₈ are as previously defined and n=0 (i.e., 29 and 30). ##STR29##

Examples of anionic four membered ring closures may be found in Corey, E. J. and Seebach, D., Org. Synth., 50, 72 (1970).

Sulfonamides of Formula L-2, L-3, L-4, L-5 and L-6 where Q is Q-4 through Q-10 and R, R₁, R₂, R₃, R₇ and R₈ are as previously defined can be prepared in a similar manner to that already taught for L-1 in Equations 14 through 17b utilizing the appropriate starting sulfonamides (e.g. 19) as described previously.

In the case where n is 1 the corresponding sulfonamides such as 31 and 32 can be prepared by the procedures outlined in Equation 18a and 18b. ##STR30##

Sulfonamide 34 where R₁₂ is OH, R₁₃ is H (n=1) can be prepared as outlined in Equation 19. ##STR31##

The use of the tert-butyldimethylsilyl group allows for low temperature generation of the anion and mild removal of the protecting group. In the same manner alkylation of 36 with ketones such as cyclobutanone allows for the preparation of sulfonamide 37 as outlined in Equation 20. ##STR32##

Preparation of a heterocyclic sulfonamide wherein R₁₂ is H and R₁₃ is OH (n=1) is accomplished in the same way as already taught for an aromatic system in Equations 19 and 20. For example, sulfonamide 38 can be prepared from protected pyrazole sulfonamide 39 as outlined in Equation 21. ##STR33##

Sulfonamides such as 34 or 38 can be used to prepare sulfonamides such as 40. Generation of the alkoxide with sodium hydride followed by the addition of the appropriate alkylating group affords protected alcohols such as 40. ##STR34##

An alternate preparation of protected alcohols. for example 41, is to trap directly the incipient lithium alkoxide (42) resulting from the condensation of the anion of 36 with aldehydes and ketones. This is depicted in Equation 23. ##STR35##

For further information pertaining to the synthesis of pyrazole sulfonamides see: EP-A- No. 95,925; for thiophene sulfonamides, EP-A- No. 30,142; for pyridine sulfonamides, EP-A- No. 13,480, and benzyl sulfonamides, EP-A- No. 51,466 and U.S. Pat. No. 4,420,325.

The heterocyclic amines of Formula III can be prepared by methods known in the literature or simple modifications thereof, by those skilled in the art. For instance. EP-A- No. 84,224 (published July 27, 1983) and W. Braker et al, J. Am. Chem. Soc. 1947, 69, 3072 describe methods for preparing aminopyrimidines and triazines substituted by acetal groups. Also, South African Patent Application Nos. 825,045 and 825,671 describe methods for preparing aminopyrimidines and triazines substituted by haloalkyl or haloalkylthio groups such as OCH₂ CH₂ F, OCH₂ CF₃, SCF₂ H, and OCF₂ H among other groups. South African Patent Application No. 837,434 (published Oct. 5, 1983) describes methods for the synthesis of cyclopropylpyrimidines and triazines substituted by such groups as alkyl, haloalkyl, alkoxy, haloalkoxy, alkylamino, dialkylamino, and alkoxyalkyl.

The 5,6-dihydrofuro[2.3-d]pyrimidin-2-amines, and the cyclopenta[d]pyrimidin-2-amines, of Formula III, where A is A-2, and the 6,7-dihydro-5H-pyrano[2.3-d]pyrimidin-2-amines, of Formula III, where A is A-3, can be prepared as described in EP-A No. 15,863. The furo[2.3-d]pyrimidin-2-amines, of Formula III, where A is A-4, are described in EP-A No. 46,677. Heterocycles of Formula III. where A is A-5, can be prepared as described in EP-A No. 73,562. Heterocycles of Formula III, where A is A-6, can be prepared by methods taught in EP-A-94,260. Heterocycles of Formula lII, where A is A-7, can be prepared by methods taught in EP-A-125,864.

In addition, general methods for preparing aminopyrimidines and triazines have been reviewed in the following publications.

"The Chemistry of Heterocyclic Compounds", a series published by Interscience Publishers. Inc., N.Y. and London:

"Pyrimidines", Vol. 16 of the same series by D. J. Brown;

"s-Triazines and Derivatives", Vol. 13 of the same series by E. M. Smolin and L. Rapaport; and

F. C. Schaefer, U.S. Pat. No. 3,154,547 and K. R. Huffman and F. C. Schaefer, J. Org. Chem., 28, 1812 (1963). which describe the synthesis of triazines.

Agriculturally suitable salts of compounds of Formula 1 are also useful herbicides and can be prepared in a number of ways known to the art. For example, metal salts can be made by contacting compounds of Formula I with a solution of an alkali or alkaline earth metal salt having a sufficiently basic anion (e.g., hydroxide, alkoxide or carbonate). Quaternary amine salts can be made by similar techniques.

Salts of compounds of Formula I can also be prepared by exchange of one cation for another. Cationic exchange can be effected by direct contacting of an aqueous solution of a salt of a compound of Formula I (e.g., alkali metal or quaternary amine salt) with a solution containing the cation to be exchanged. This method is most effective when the desired salt containing the exchanged cation is insoluble in water, e.g., a copper salt, and can be separated by filtration.

Exchange may also be effected by passing an aqueous solution of a salt of a compound of Formula I (e.g., an alkali metal or quaternary amine salt) throuqh a column packed with a cation exchange resin containing the cation to be exchanged. In this method, the cation of the resin is exchanged for that of the original salt and the desired product is eluted from the column. This method is particularly useful when the desired salt is water-soluble, e.g., a potassium, sodium or calcium salt.

Acid addition salts, useful in this invention, can be obtained by reacting a compound of Formula I with a suitable acid, e.g., p-toluenesulfonic acid, trichloroacetic acid or the like.

The preparation of the compounds of this invention is illustrated by the following examples.

EXAMPLE 1 Preparation of 2-Ethenylbenzenesulfonamide

2-Bromostyrene (10.0 g, 54.9 mmol) was added dropwise to n-BuLi in 250 ml of tetrahydrofuran ar -78° C. After stirring for 15 minutes the solution was added via a cannula to a solution of sulfurylchloride fluoride (9.7 g, 82.4 mmol) in 50 ml of tetrahydrofuran cooled to -78° C. The reaction mixture was quenched with brine and separated.The organic layer was dried and concentrated to approximately half-volume. This solution was added to anhydrous ammonia (100 ml) cooled to -78° C. The reaction was warmed to room temperature, excess ammoniawas removed and the solids were filtered off. The filtrate was concentratedand the resulting oil was triturated with butyl chloride and ethyl acetate to yield the desired sulfonamide, m.p. 103°-105° C.

EXAMPLE 2 Preparation of 2-(2-Oxiranyl)benzenesulfonamide

A solution consisting of 2-ethenylbenzenesulfonamide (1.5 g, 8.1 mmol) m-chloroperbenzoic acid (1.4 g, 8.1 mmol) and potassium carbonate (1.1 g, 8.1 mmol) in 150 ml of chloroform was stirred for 4 days at room temperature. The reaction was filtered and the filtrate was washed with saturated sodium bicarbonate. The organic layer was separated, dried and concentrated. The resulting oil was flash chromatographed (methylene chloride) to yield the subject compound as a white solid. m.p. 136°-139° C.

EXAMPLE 3 Preparation of 1-Bromo-2-(2,2-Dichlorocyclopropyl)benzene

A 20 ml solution of 50% sodium hyroxide was added dropwise to 2-bromostyrene (10.0 g, 54.9 mmol) in 100 ml of chloroform. The reaction mixture was warmed to 45° C. for 1 hour. After cooling the solutionwas separated and the organic layer was dried over magnesium sulfate and concentrated. The resulting liquid was flash chromatographed, affording 11.6 g of the desired compound.

EXAMPLE 4 Preparation of N-[(4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(2-oxiranyl)benzenesulfonamide

To a stirring solution of the 2-(2-oxiramyl)benzenesulfonamide (75 mg, 0.376 mmol) and 4,6-dimethoxy-2-aminophenoxycarbonyl pyrimidine (103 mg, 0.37 mmol) in 5 ml of acetonitrile was added 1,8-diazabicyclo-[5.4.0]undec-7-ene (57 mg, 0.37 mmol). The reaction was stirred for 3 hours followed by quenching with 3 ml of 5% hydrochloric acid. The solution was diluted with ethyl acetate, separated and dried. The organics were concentrated to yield 140 mg of the desired product, m.p. 177°-179° C.; NMR (200 MHz, CDCl₃)δ: 2.3 (dd, 1H): 3.1 (dd, 1H); 3.95 (s, 6H); 4.7 (dd, 1H): 5.88 (s, 1H); 7.0 (br s, 1H); 7.55 (m, 3H) and 8.2 (dd, 1H).

EXAMPLE 5 Preparation of 2-(2,2-Dichlorocyclopropyl)-N-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]benzenesulfonamide

To a stirring solution of 2-(2,2-dichlorocyclopropyl)benzenesulfonamide (200 mg. 0.75 mmol) and 4-methyl-6-methoxy-2-aminophenoxycarbonyl pyrimidine (195 mg, 0.75 mmol) was added 1,8-diazabicyclo[5.4.0]-undec-7-ene (115 mg, 0.75 mmol). Work-up as described in Example 4 afforded 180 mg of the desired compound, m.p. 187°-191° C.; NMR (200 MHz, CDCl₃)δ: 2.05 (dd, 2H); 2.41 (s, 3H); 3.79 (dd, 1H): 3.94 (s, 3H): 6.27 (s, 1H); 7.2 (d, 1H);7.57 (m, 3H) and 8.4 (dd, 1H).

EXAMPLE 6 2-[(Cyclopropyl)(hydroxy)methyl]-N-[(dimethyl((1,1-dimethylethyl)silyl]benzenesulfonamide

To a stirring solution of n-BuLi (5.2 g, 80.8 mmol) in 300 ml of THF cooledto -10° C. was added dropwise tert-butyldimethylsilylbenzenesulfonamide (10.0 g, 36.7 mmol) in 25 ml of THF. The solution was stirred for one hour. After cooling to -78° C., cyclopropyl aldehyde (2.8 g, 40.0 mmol) was added. The reaction mixture was stirred for 30 minutes, then quenched with brine. The organic layer was separated, dried over magnesium sulfate and concentrated in vacuo. Flash chromatography (20% EtOAc:hexane. v/v) afforded 2.7 g of the desired product as a viscous oil; NMR (200 MHz, CDCl₃): δ 0.24 (d, 6H), 0.4 (m, 1H), 0.45-0.8 (m, 3H). 0.88 (s, 9H)), 1.6 (m, 1H), 2.85 (d, 1H), 4.9 (dd, 1H), 5.30 (s, 1H), 5.67 (brs, 1H), 7.41 (t, 1H), 7.54 (t, 1H), 7.76 (d, 1H), 7.98 (d, 1H).

EXAMPLE 7 N-[(4,6-Dimethylpyrimidin-2-yl)aminocarbonyl]-2-(1-hydroxycyclobutyl)benzenesulfonamide

To a mixture of the phenylcarbamate of 4,6-dimethyl-2-aminopyrimidine (178 mg, 0.73 mmol) and tert-butyldimethylsilane-protected 2-(1-hydroxycylcobutane)benzenesulfonamide in 5 ml of acetonitrile was added tetrabutylammonium fluoride (231 mg, 0.73 mmol). The reaction mixture was stirred for 5 minutes followed by the addition of 5% HCl. The resulting solids were collected and dried to give 250 mg of the desired product; m.p. 148°-150° C.; NMR (200 MHz, CDCl₃); δ 2.45 (s,7H), 2.58 (m, 5H), 6.76 (s, 1H), 7.47-7.75 (m, 4H), 8.32 (d, 1H).

                  TABLE OF STRUCTURES                                              ______________________________________                                         General Structure I                                                             ##STR36##                                                                     where W is O unless otherwise indicated by *.                                  where W is S.                                                                  For ring systems Q-4 through Q-10, the substituents                            R.sub.7 and R.sub.8 are attached as follows                                     ##STR37##                                                                     General Structure II                                                            ##STR38##                                                                      ##STR39##                                                                      ##STR40##                                                                     For ring systems Q-4 through Q-10, the substituents                            R.sub.7 and R.sub.8 are attached as follows                                     ##STR41##                                                                     General Structure IIa                                                           ##STR42##                                                                      ##STR43##                                                                      ##STR44##                                                                     General Structure IIb                                                           ##STR45##                                                                      ##STR46##                                                                      ##STR47##                                                                     General Structure III                                                           ##STR48##                                                                     General Structure IV                                                            ##STR49##                                                                     L-2 and L-3 are as in                                                          General Structure II.                                                          n = O                                                                          General Structure V                                                             ##STR50##                                                                     L-2 and L-3 are as in                                                          General Structure II.                                                          R.sub.9 and R.sub.10 are C = O                                                 n = O                                                                          ______________________________________                                    

                                      TABLE I                                      __________________________________________________________________________     General Structure I (wherein R.sub.12 and R.sub.13 are H)                      Q  n  R  R.sub.1                                                                          R.sub.7                                                                             R.sub.8                                                                               R.sub.9                                                                            R.sub.10                                                                          R.sub.11                                                                          X     Y     Z   m.p. (°C.)             __________________________________________________________________________     Q-1                                                                               0  H  H H    H      H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH  197-198.5                     Q-1                                                                               0  H  H H    H      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH  209-210                       Q-1                                                                               0  H  H H    H      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH  202-204                       Q-1                                                                               0  CH.sub.3                                                                          H H    H      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N   144-146                       Q-1                                                                               0  H  H H    H      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N   190-191                       Q-1                                                                               0  H  H H    H      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N   174-176                       Q-1                                                                               0  H  H H    H      H   H  -- CL    OCH.sub.3                                                                            CH  192-194                       Q-1                                                                               0  H  H H    F      H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H H    G      H   H  -- CH.sub.3                                                                             CH.sub. 3                                                                            N                                 Q-1                                                                               0  H  H H    F      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    Cl     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH  174-177                       Q-1                                                                               0  H  H H    Cl     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N   172-175                       Q-1                                                                               0  H  H Cl   H      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH  186-188                       Q-1                                                                               0  H  H Cl   H      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N   156-160                       Q-1                                                                               0  H  H H    Br     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H Br   H      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Br   H      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    I      H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H H    H      H   H  -- NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                   N   203-206                       Q-1                                                                               0  H  H H    CN     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CN   H      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CH.sub. 3                                                                             H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH  155-159                       Q-1                                                                               0  H  H H    CH.sub.3                                                                              H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH  180-182                       Q-1                                                                               0  H  H H    CH.sub.3                                                                              H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH  215-216                       Q-1                                                                               0  H  H CH.sub.3                                                                            H      H   H  -- Cl    OCH.sub.3                                                                            N   175-176                       Q-1                                                                               0  H  H CH.sub.3                                                                            H      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N   154-157                       Q-1                                                                               0  H  H H    CH.sub.2 CH.sub.3                                                                     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CH.sub.2 CH.sub.3                                                                   H      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CH.sub.2 CH.sub.3                                                                     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CH.sub.2 CH.sub.2 CH.sub.3                                                            H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    Cl     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH  182-185                       Q-1                                                                               0  H  H H    Cl     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N   139-142                       Q-1                                                                               0  H  H H    Cl     H   H  -- Cl    OCH.sub.3                                                                            CH  185-187                       Q-1                                                                               0  H  H H    Cl     H   H  -- OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                           CH  154-158                       Q-1                                                                               0  H  H H    Br         CH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H H    Br     H   Cl -- OCH.sub.3                                                                            CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H H    Br     H   F  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H H    Br     H   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    Br     H   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    Br     H   Br -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    I      H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CN     H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CN     H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CN     H   Cl -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H H    CN     H   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CN     H   Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CN     CH.sub.3                                                                           H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H H    OCH.sub.3                                                                             H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    OCH.sub.3                                                                             H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    OCH.sub.3                                                                             H   Cl -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    OCH.sub.3                                                                             Cl  H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    OCH.sub.3                                                                             F   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    OCH.sub.3                                                                             H   Br -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H H    CO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H H    CO.sub.2 CH.sub.3                                                                     H   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CO.sub.2 CH.sub.3                                                                     H   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CO.sub.2 CH.sub.3                                                                     H   Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CO.sub.2 CH.sub.3                                                                     H   Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    SO.sub.2 N(CH.sub.3).sub.2                                                            H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    SO.sub.2 N(CH.sub.3).sub.2                                                            H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    SO.sub.2 N(CH.sub.3).sub.2                                                            H   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    SO.sub.2 N(CH.sub.3).sub.2                                                            H   Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    SO.sub.2 N(CH.sub.3).sub.2                                                            H   Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    SCH.sub.3                                                                             H   CH.sub.3                                                                          -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    SCH.sub.3                                                                             H   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    SCH.sub.3                                                                             H   Cl -- CH.sub.3                                                                             OCH.sub. 3                                                                           CH                                Q-1                                                                               0  H  H H    OCH.sub.3                                                                             H   Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    OCH.sub.3                                                                             H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H H    OCH.sub.3                                                                             H   H  -- OCH.sub.3                                                                            CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H CH.sub.3 O                                                                          H      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    OCH.sub.2 CH.sub.3                                                                    H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CO.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CO.sub.2 CH.sub.3                                                                     H   H  -- OCH.sub.3                                                                            OHC.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CO.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CO.sub.2 CH.sub.3                                                                     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CO.sub.2 CH.sub.2 CH.sub.3                                                            H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    SO.sub.2 N(CH.sub.3).sub.2                                                            H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    SO.sub.2 N(CH.sub.3).sub.2                                                            H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H H    SCH.sub.3                                                                             H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    SCH.sub.3                                                                             H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H H    SO.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    SO.sub.2 CH.sub.3                                                                     H   H  -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    SO.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    SO.sub.2 CH.sub.2 CH.sub.3                                                            H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CH.sub.3                                                                              H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CH.sub.3                                                                              H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CH.sub.3                                                                              CH.sub.3                                                                           H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H H    CH.sub.3                                                                              H   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CH.sub.3                                                                              H   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CH.sub.3                                                                              H   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CH.sub.3                                                                              H   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CH.sub.3                                                                              Br  H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    F      H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    F      H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    Cl     H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    Cl     H   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    Cl     H   Cl -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    Cl     H   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    Cl     H   Br -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    SO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H H    SO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H H    SO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    SO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H H    SO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    SO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    SO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    SO.sub.2 CH.sub.3                                                                     H   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    SO.sub.2 CH.sub.3                                                                     H   Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    SO.sub.2 CH.sub.3                                                                     H   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    SO.sub.2 CH.sub.3                                                                     H   Br -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H F    F      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H F    F      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H F    F      H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H F    F      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H F    F      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H F    F      H   H  -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Cl   Cl     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH  187-191                       Q-1                                                                               0  H  H Cl   Cl     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH  193-195                       Q-1                                                                               0  H  H Cl   Cl     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N   168-170                       Q-1                                                                               0  H  H Cl   Cl     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N   190-193                       Q-1                                                                               0  H  H Cl   Cl     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH  233-235                       Q-1                                                                               0  H  H Cl   Cl     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N   195-199                       Q-1                                                                               0  H  H Cl   Cl     H   H  -- Cl    OCH.sub.3                                                                            CH  199-202                       Q-1                                                                               0  H  H Br   Br     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Br   Br     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Br   Br     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Br   Br     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Br   Br     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H Br   Br     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H I    I      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CN   CN     H   H  -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CN   CN     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CN   CN     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CN   CN     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CN   CN     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H CN   CN     H   H  -- OCH.sub.3                                                                            CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             H   H  -- Cl    OCH.sub.3                                                                            CH  154-156                       Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N   152 -155                      Q-1                                                                               0  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH  179-180                       Q-1                                                                               0  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H F    F      H   CH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H F    F      H   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H F    F      H   Cl -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H F    F      H   Br -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Cl   Cl     H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Cl   Cl     H   Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Cl   Cl     H   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Cl   Cl     H   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Cl   Cl     H   Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Br   Br     H   CH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H Br   Br     H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Br   Br     H   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Br   Br     H   Cl -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H Br   Br     Cl  H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Br   Br     H   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Br   Br     H   Br -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CN   CN     H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CN   CN     H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CN   CN     H   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   CH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              CH.sub.3                                                                           H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   Br -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             H   CH.sub.3                                                                          -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             H   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CO.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H F    F      CH.sub.3                                                                           CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H F    F      CH.sub.3                                                                           CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H F    F      F   F  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H F    F      F   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H F    F      F   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H F    F      Cl  Cl -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H F    F      Cl  Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H F    F      Br  Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H F    F      Br  Br -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Cl   Cl     CH.sub.3                                                                           CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Cl   Cl     CH.sub.3                                                                           CH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H Cl   Cl     CH.sub.3                                                                           CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Cl   Cl     F   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Cl   Cl     F   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Cl   Cl     Cl  Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Cl   Cl     Cl  Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Cl   Cl     Br  Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Cl   Cl     Br  Br -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H I    I      CH.sub.3                                                                           CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CN   CN     CH.sub.3                                                                           CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CN   CN     CH.sub.3                                                                           CH.sub.3                                                                          -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CN   CN     F   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CN   CN     CH.sub.3                                                                           CH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H CN   CN     F   F  -- OCH.sub.3                                                                            CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H CN   CN     F   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CN   CN     Cl  Cl -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H CN   CN     Br  Br -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CN   CN     Br  Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              CH.sub.3                                                                           CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              CH.sub.3                                                                           CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              CH.sub.3                                                                           CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              F   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              Cl  Cl -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              Cl  Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              Cl  Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              Br  Br -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H CH.sub.3                                                                            CH.sub.3                                                                              Br  Br -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.3                                                                           CH.sub.3                                                                          -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.3                                                                           CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             Cl  Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             F   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             F   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             F   F  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             Br  Br -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             Br  Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H F    Cl     H   H  -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H F    Br     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H F    CH.sub.3                                                                              H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H F    CN     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H F    CH.sub.2 CH.sub.3                                                                     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H F    OCH.sub.3                                                                             H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H F    CO.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H F    SO.sub.2 N(CH.sub.3).sub.2                                                            H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H F    SCH.sub.3                                                                             H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H F    SO.sub.2 CH.sub.3                                                                     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Cl   F      H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H Cl   F      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Cl   Br     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Cl   F      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Cl   CN     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Cl   CH.sub.3                                                                              H   H  -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Cl   CH.sub.3                                                                              H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Cl   OCH.sub.3                                                                             H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H Cl   OCH.sub.3                                                                             H   H  -- OCH.sub.3                                                                            CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H Cl   CO.sub.2 CH.sub.3                                                                     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Cl   SO.sub.2 N(CH.sub.3).sub.2                                                            H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H Cl   SCH.sub.3                                                                             H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Cl   SO.sub.2 CH.sub.3                                                                     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Br   F      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Br   F      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Br   F      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Br   Cl     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Br   Cl     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H Br   Cl     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Br   Br     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Br   CN     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H Br   CH.sub.3                                                                              H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Br   CH.sub.3                                                                              H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Br   CH.sub.3                                                                              H   H  -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Br   CH.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Br   OCH.sub.3                                                                             H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Br   OCH.sub.3                                                                             H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H Br   CO.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H Br   SO.sub.2 N(CH.sub.3).sub.2                                                            H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Br   SCH.sub.3                                                                             H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Br   SO.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H I    F      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H I    Cl     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H I    Br     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H I    CH.sub.3                                                                              H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CN   F      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CN   Cl     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CN   Br     H   H  -- Cl    OCH.sub. 3                                                                           CH                                Q-1                                                                               0  H  H CN   Br     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CN   CH.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CN   OCH.sub.3                                                                             H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H CN   CO.sub.2 CH.sub.3                                                                     H   H  -- OCH.sub.3                                                                            CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H CN   SCH.sub.3                                                                             H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CN   SO.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H H    F      F   Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    F      F   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    F      Cl  Br -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    F      Br  F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CH.sub.3                                                                              F   Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CH.sub.3                                                                              F   Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CH.sub.3                                                                              F   CH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H H    CH.sub.3                                                                              Br  CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CH.sub.3                                                                              Cl  CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    Cl     F   Cl -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               0  H  H H    Cl     F   Br -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    Cl     Br  Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    Cl     F   CH.sub.3                                                                          -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CN     F   Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CN     F   Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CN     F   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CN     Cl  CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CN     Cl  Br -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H H    CH.sub.3                                                                              F   Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CH.sub.3                                                                              F   Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CH.sub.3                                                                              F   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CH.sub.3                                                                              Cl  Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    CH.sub.3                                                                              Cl  Br -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CH.sub.3                                                                              Br  CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CH.sub.2 CH.sub.3                                                                     F   Cl.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    CH.sub.2 CH.sub.2 CH.sub.3                                                            F   Br -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    OCH.sub.3                                                                             F   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    OCH.sub.3                                                                             F   Br -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H H    OCH.sub.3                                                                             F   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H H    OCH.sub.3                                                                             Cl  Br -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H F    Cl     F   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H F    Cl     F   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H F    Br     Cl  CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Cl   CH.sub.3                                                                              CH.sub.3                                                                           F  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               0  H  H Br   OCH.sub.3                                                                             CH.sub.3                                                                           F  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H SCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                     F   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Br   Cl     F   Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H Br   I      F   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               0  H  H CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                           Br -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Cl   Br     Cl  Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H Cl   Br     Cl  CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H I    F      F   Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CN   F      F   Cl -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               0  H  H CN   Br     Cl  CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    H      H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H H    H      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    H      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    H      H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               1  H  H H    H      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    H      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    H      H   H  -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    F      H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H H    F      H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               1  H  H H    F      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    Cl     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    Cl     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               1  H  H Cl   H      H   H  -- CH.sub. 3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Cl   H      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    Br     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H Br   H      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Br   H      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    I      H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               1  H  H I    H      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    CN     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H CN   H      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    CH.sub.3                                                                              H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H H    CH.sub.3                                                                              H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    CH.sub.3                                                                              H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CH.sub.3                                                                            H      H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               1  H  H CH.sub.3                                                                            H      H   H  -- CH.sub. 3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    CH.sub.2 CH.sub.3                                                                     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    CH.sub.2 CH.sub.3                                                                     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    CH.sub.2 CH.sub.2 CH.sub.3                                                            H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    OCH.sub.3                                                                             H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H H    OCH.sub.3                                                                             H   H  -- OCH.sub.3                                                                            CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H CH.sub.3 O                                                                          H      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    OCH.sub.2 CH.sub.3                                                                    H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               1  H  H H    CO.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    CO.sub.2 CH.sub.3                                                                     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    CO.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    CO.sub.2 CH.sub.3                                                                     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    CO.sub.2 CH.sub.2 CH.sub.3                                                            H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    SO.sub.2 N(CH.sub.3).sub.2                                                            H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    SO.sub.2 N(CH.sub.3).sub.2                                                            H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H H    SCH.sub.3                                                                             H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    SCH.sub.3                                                                             H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               1  H  H H    SO.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H SO.sub.2 CH.sub.3                                                                   H      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    SO.sub.2 CH.sub.3                                                                     H   H  -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    SO.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    SO.sub.2 CH.sub.2 CH.sub.3                                                            H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    CH.sub.3                                                                              H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    CH.sub.3                                                                              H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    CH.sub.3                                                                              CH.sub.3                                                                           H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H H    CH.sub.3                                                                              H   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    CH.sub.3                                                                              H   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    CH.sub.3                                                                              H   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    CH.sub.3                                                                              H   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    CH.sub.3                                                                              Br  H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    F      H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    F      H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    Cl     H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    Cl     H   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    Cl     H   Cl -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    Cl     H   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    Cl     H   Br -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    SO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- OH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H H    SO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H H    SO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    SO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               1  H  H H    SO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    SO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    SO.sub.2 CH.sub.3                                                                     H   CH.sub.3                                                                          -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    SO.sub.2 CH.sub.3                                                                     H   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H H    SO.sub.2 CH.sub.3                                                                     H   Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    SO.sub.2 CH.sub.3                                                                     H   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H H    SO.sub.2 CH.sub.3                                                                     H   Br -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H F    F      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H F    F      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H F    F      H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               1  H  H F    F      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H F    F      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H F    F      H   H  -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Cl   Cl     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Cl   Cl     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Cl   Cl     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Cl   Cl     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Cl   Cl     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H Cl   Cl     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               1  H  H Cl   Cl     H   H  -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Br   Br     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Br   Br     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Br   Br     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Br   Br     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Br   Br     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               1  H  H I    I      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CN   CN     H   H  -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CN   CN     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H CN   CN     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H F    F      H   CH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H F    F      H   CH.sub.3                                                                          -- OCH.sub.3                                                                            CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H F    F      H   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H F    F      H   Cl -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               1  H  H F    F      H   Br -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Cl   Cl     H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Cl   Cl     H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Cl   Cl     H   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Cl   Cl     H   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Cl   Cl     H   Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Br   Br     H   CH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H Br   Br     H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Br   Br     H   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Br   Br     H   Cl -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               1  H  H Br   Br     Cl  H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Br   Br     H   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Br   Br     H   Br -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CN   CN     H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CN   CN     H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CN   CN     H   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   CH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CH.sub.3                                                                            CH.sub.3                                                                              CH.sub.3                                                                           H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CH.sub.3                                                                            CH.sub.3                                                                              H   Br -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             H   CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             H   CH.sub.3                                                                          -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             H   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H CN   CN     CH.sub.3                                                                           CH.sub.3                                                                          -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H CN   CN     F   F  -- OCH.sub.3                                                                            CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H CN   CN     F   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CN   CN     Cl  Cl -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               1  H  H CN   CN     Br  Br -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H CN   CN     Br  Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H CH.sub.3                                                                            CH.sub.3                                                                              CH.sub.3                                                                           CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CH.sub.3                                                                            CH.sub.3                                                                              CH.sub.3                                                                           CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CH.sub.3                                                                            CH.sub.3                                                                              CH.sub.3                                                                           CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H CH.sub.3                                                                            CH     F   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H CH.sub.3                                                                            CH.sub.3                                                                              Cl  Cl -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H CH.sub.3                                                                            CH.sub.3                                                                              Cl  Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CH.sub.3                                                                            CH.sub.3                                                                              Cl  Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CH.sub.3                                                                            CH.sub.3                                                                              Br  Br -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               1  H  H CH.sub.3                                                                            CH.sub.3                                                                              Br  Br -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.3                                                                           CH.sub.3                                                                          -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.3                                                                           CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             Cl  Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             F   F  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             F   F  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             F   F  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H OCH.sub.3                                                                           OCH.sub.3                                                                             Br  Br -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Cl   OCH.sub.3                                                                             H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H Cl   OCH.sub.3                                                                             H   H  -- OCH.sub.3                                                                            CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H Cl   CO.sub.2 CH.sub.3                                                                     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Cl   SO.sub.2 N(CH.sub.3).sub.2                                                            H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               1  H  H Cl   SCH.sub.3                                                                             H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Cl   SO.sub.2 CH.sub.3                                                                     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Br   F      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Br   F      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Br   F      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Br   Cl     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Br   Cl     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H Br   Cl     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Br   Br     H   H  -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Br   CN     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             N                                 Q-1                                                                               1  H  H Br   CH.sub.3                                                                              H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Br   CH.sub.3                                                                              H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Br   CH.sub.3                                                                              H   H  -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Br   CH.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Br   OCH.sub.3                                                                             H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Br   OCH.sub.3                                                                             H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Br   OCH.sub.2 CH.sub.3                                                                    H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Br   CO.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H Br   SO.sub.2 N(CH.sub.3).sub.2                                                            H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Br   SCH.sub.3                                                                             H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Br   SO.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H I    F      H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H I    Cl     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H I    Br     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H I    CH.sub.3                                                                              H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CN   F      H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H CN   Cl     H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CN   Br     H   H  -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CN   CH.sub.3                                                                              H   H  -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H CN   CH.sub.2 CH.sub.3                                                                     H   H  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H F    Cl     F   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H F    Cl     F   CH.sub.3                                                                          -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H F    Br     Cl  CH.sub.3                                                                          -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Cl   CH.sub.3                                                                              CH.sub.3                                                                           F  -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H Br   OCH.sub.3                                                                             CH  F  -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Br   Cl     F   Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H Br   I      F   Cl -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H CH   CH.sub.2 CH.sub.3                                                                     CH.sub.3                                                                           Br -- CH.sub.3                                                                             OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Cl   Br     Cl  Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H Cl   Br     Cl  CH -- CH.sub.3                                                                             CH.sub.3                                                                             CH                                Q-1                                                                               1  H  H CO.sub.2 CH.sub.3                                                                   SCH.sub.3                                                                             F   Cl -- CH.sub.3                                                                             OCH.sub.3                                                                            N                                 Q-1                                                                               1  H  H I    F      F   Br -- OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CN   F      F   Cl -- Cl    OCH.sub.3                                                                            CH                                Q-1                                                                               1  H  H CN   Br     Cl  CH -- OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 __________________________________________________________________________     Q  n  R   R.sub.1                                                                             R.sub.7                                                                              R.sub.8                                                                               R.sub.11                                                                            X     Y    Z   m.p. (°C.)              __________________________________________________________________________     Q-2                                                                               0  H   H    H     H      H    CH.sub.3                                                                             CH.sub.3                                                                            CH  158-160                        Q-2                                                                               0  H   H    H     H      H    CH.sub.3                                                                             OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     H      H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH  177-179                        Q-2                                                                               0  H   H    H     H      H    CH.sub.3                                                                             CH.sub.3                                                                            N                                  Q-2                                                                               0  H   H    H     H      H    CH.sub.3                                                                             OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   H    H     H      H    OCH.sub.3                                                                            OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   H    H     H      H    Cl    OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     CH.sub.3                                                                              H    CH.sub.3                                                                             OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     CH.sub.3                                                                              H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     CH.sub.3                                                                              H    OCH.sub.3                                                                            OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   H    H     CH.sub.3                                                                              H    CH.sub.3                                                                             OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     Cl     H    CH.sub.3                                                                             OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     Cl     H    OCH.sub.3                                                                            CH.sub.3                                                                            N                                  Q-2                                                                               0  H   H    H     Cl     H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     Cl     H    Cl    OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     F      H    CH.sub.3                                                                             CH.sub.3                                                                            N                                  Q-2                                                                               0  H   H    H     F      H    CH.sub.3                                                                             CH.sub.3                                                                            CH                                 Q-2                                                                               0  H   H    H     F      H    OCH.sub.3                                                                            CH.sub.3                                                                            CH                                 Q-2                                                                               0  H   H    H     F      H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     F      H    CH.sub.3                                                                             OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   H    H     F      H    Cl    OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     CN     H    CH    OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   H    H     CN     H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     OCH.sub.3                                                                             H    CH.sub.3                                                                             OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   H    H     OCH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     OCH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   H    H     CO.sub.2 CH.sub.3                                                                     H    CH.sub.3                                                                             CH.sub.3                                                                            N                                  Q-2                                                                               0  H   H    H     CO.sub.2 CH.sub.3                                                                     H    OCH.sub.3                                                                            CH.sub.3                                                                            CH                                 Q-2                                                                               0  H   H    H     CO.sub.2 CH.sub.3                                                                     H    OCH.sub.3                                                                            OCH.sub. 3                                                                          CH                                 Q-2                                                                               0  H   H    H     CO.sub.2 CH.sub.3                                                                     H    CH.sub.3                                                                             OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   H    H     CO.sub.2 CH.sub.3                                                                     H    CH.sub.3                                                                             CH.sub.3                                                                            CH                                 Q-2                                                                               0  H   H    H     CO.sub.2 CH.sub.3                                                                     H    OCH.sub.3                                                                            OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   H    H     CO.sub.2 CH.sub.3                                                                     H    Cl    OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     SO.sub.2 N(CH.sub.3).sub.2                                                            H    CH.sub.3                                                                             CH.sub.3                                                                            N                                  Q-2                                                                               0  H   H    H     SO.sub.2 N(CH.sub.3).sub.2                                                            H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     SO.sub.2 N(CH.sub.3).sub.2                                                            H    OCH.sub.3                                                                            OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   H    H     SO.sub.2 N(CH.sub.3).sub.2                                                            H    CH.sub.3                                                                             OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     SCH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     SCH.sub.3                                                                             H    CH.sub.3                                                                             CH.sub.3                                                                            CH                                 Q-2                                                                               0  H   H    H     SCH.sub.3                                                                             H    OCH.sub.3                                                                            CH.sub.3                                                                            CH                                 Q-2                                                                               0  H   H    H     SCH.sub.3                                                                             H    Cl    OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     SO.sub.2 CH.sub.3                                                                     H    CH.sub.3                                                                             CH.sub.3                                                                            CH                                 Q-2                                                                               0  H   H    H     SO.sub.2 CH.sub.3                                                                     H    CH.sub.3                                                                             OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     SO.sub.2 CH.sub.3                                                                     H    CH.sub.3                                                                             OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   H    F     F      H    CH.sub.3                                                                             CH.sub.3                                                                            CH                                 Q-2                                                                               0  H   H    F     F      H    OCH.sub.3                                                                            CH.sub.3                                                                            CH                                 Q-2                                                                               0  H   H    Cl    Cl     H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    Cl    Cl     H    CH.sub.3                                                                             CH.sub.3                                                                            N                                  Q-2                                                                               0  H   H    F     Cl     H    OCH.sub.3                                                                            CH.sub.3                                                                            N                                  Q-2                                                                               0  H   H    F     CH.sub.3                                                                              H    CH.sub.3                                                                             CH.sub.3                                                                            CH                                 Q-2                                                                               0  H   H    CH.sub.3                                                                             CH.sub.3                                                                              H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    CH    CH.sub.3                                                                              H    OCH.sub.3                                                                            OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   H    F     Br     H    Cl    OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    Br    Br     H    Cl    OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    Br    Br     H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    CO.sub.2 CH.sub.3                                                                    CO.sub.2 CH.sub.3                                                                     H    CH.sub.3                                                                             CH.sub.3                                                                            N                                  Q-2                                                                               0  H   H    CO.sub.2 CH.sub.3                                                                    CO.sub.2 CH.sub.3                                                                     H    CH.sub.3                                                                             OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    CO.sub.2 CH.sub.3                                                                    CO.sub.2 CH.sub.3                                                                     H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    CN    CN     H    CH.sub.3                                                                             OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    CN    CN     H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    CN    CN     H    OCH.sub.3                                                                            OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   H    OCH.sub.3                                                                            OCH.sub.3                                                                             H    CH.sub.3                                                                             OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    OCH.sub.2 CH.sub.3                                                                   OCH2CH.sub.3                                                                          H    OCH.sub.3                                                                            CH.sub.3                                                                            CH                                 Q-2                                                                               0  H   H    SCH.sub.3                                                                            SCH.sub.3                                                                             H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    SCH.sub.3                                                                            SCH.sub.3                                                                             H    CH.sub.3                                                                             CH.sub.3                                                                            N                                  Q-2                                                                               0  H   H    SO.sub.2 CH.sub.3                                                                    SO.sub.2 CH.sub.3                                                                     H    CH.sub.3                                                                             OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    SO.sub.2 CH.sub.3                                                                    SO.sub.2 CH.sub.3                                                                     H    OCH.sub.3                                                                            OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   H    H     H      CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                            CH                                 Q-2                                                                               0  H   H    H     H      CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     H      CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    H     H      CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             CH.sub.3                                                                            N                                  Q-2                                                                               0  H   H    F     H      CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   H    Cl    H      CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   H    F     F      CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    Br    H      CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   H    Cl    Cl     CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   5-OCH.sub. 3                                                                        H     H      --   OCH.sub.3                                                                            OCH.sub.3                                                                           N                                  Q-2                                                                               0  H   5-OCH.sub. 3                                                                        H     H      --   CH.sub.3                                                                             CH.sub.3                                                                            CH                                 Q-2                                                                               0  H   5-SCH.sub. 3                                                                        H     H      --   CH.sub.3                                                                             OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   5-Cl Cl    H      --   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               0  H   6-Cl F     F      CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                            N                                  Q-2                                                                               0  CH.sub.3                                                                           H    H     H      H    OCH.sub.3                                                                            OCH.sub.3                                                                           N                                  Q-2                                                                               1  H   H    H     H      H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               1  H   H    F     F      H    CH.sub.3                                                                             OCH.sub.3                                                                           CH                                 Q-2                                                                               1  H   H    F     Cl     H    CH.sub.3                                                                             CH.sub.3                                                                            N                                  Q-2                                                                               1  H   H    CH.sub.3                                                                             Cl     H    OCH.sub.3                                                                            CH.sub.3                                                                            CH                                 Q-2                                                                               1  H   H    F     H      H    CH.sub.3                                                                             OCH.sub.3                                                                           CH                                 Q-2                                                                               1  H   H    Cl    H      H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               1  H   H    Br    H      H    CH.sub.3                                                                             CH.sub.3                                                                            N                                  Q-2                                                                               1  H   H    Cl    Cl     H    CH.sub.3                                                                             OCH.sub.3                                                                           CH                                 Q-2                                                                               1  H   H    CH.sub.3                                                                             H      H    CH.sub.3                                                                             OCH.sub.3                                                                           CH                                 Q-2                                                                               1  H   H    CH.sub.3                                                                             H      H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               1  H   H    CH.sub.3                                                                             CH.sub.3                                                                              H    CH.sub.3                                                                             OCH.sub.3                                                                           N                                  Q-2                                                                               1  H   H    CH.sub.3                                                                             Br     H    CH.sub.3                                                                             CH.sub.3                                                                            CH                                 Q-2                                                                               1  H   H    F     Br     H    Cl    OCH.sub.3                                                                           CH                                 Q-2                                                                               1  H   5-CH.sub.3                                                                          F     H      H    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                 Q-2                                                                               1  H   5-OCH.sub.3                                                                         Cl    CH     CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                            N                                  Q-2                                                                               1  H   5-Cl Cl    Cl     CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             OCH.sub.3                                                                           N                                  __________________________________________________________________________     Q  n R  R.sub.1                                                                             R.sub.3                                                                               R.sub.7                                                                            R.sub.8                                                                               R.sub.11                                                                            X    Y    Z  m.p. (°C.)             __________________________________________________________________________     Q-3                                                                               0 H  H    CH.sub.3                                                                              H   H      H    CH.sub.3                                                                            CH.sub.3                                                                            CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   H      H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   H      H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   H      H    CH.sub.3                                                                            CH.sub.3                                                                            N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              H   H      H    CH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              H   H      H    Cl   OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   CH.sub.3                                                                              H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   CH.sub.3                                                                              H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   CH.sub.3                                                                              H    OCH.sub.3                                                                           OCH.sub.3                                                                           N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              H   CH.sub.3                                                                              H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   Cl     H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   Cl     H    OCH.sub.3                                                                           OCH.sub.3                                                                           N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              H   Cl     H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   Cl     H    Cl   OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   F      H    CH.sub.3                                                                            CH.sub.3                                                                            N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              H   F      H    CH.sub.3                                                                            CH.sub.3                                                                            CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   F      H    OCH.sub.3                                                                           CH.sub.3                                                                            CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   F      H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   F      H    CH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              H   F      H    Cl   OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   CN     H    CH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              H   CN     H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   OCH.sub.3                                                                             H    CH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              H   OCH.sub.3                                                                             H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   OCH.sub.3                                                                             H    OCH.sub.3                                                                           OCH.sub.3                                                                           N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              H   CO.sub.2 CH.sub.3                                                                     H    CH.sub.3                                                                            CH.sub.3                                                                            N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              H   CO.sub.2 CH.sub.3                                                                     H    OCH.sub.3                                                                           CH.sub.3                                                                            CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   CO.sub.2 CH.sub.3                                                                     H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   CO.sub. 2 CH.sub.3                                                                    H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   CO.sub.2 CH.sub.3                                                                     H    CH.sub.3                                                                            CH.sub.3                                                                            CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   CO.sub.2 CH.sub.3                                                                     H    OCH.sub.3                                                                           OCH.sub.3                                                                           N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              H   CO.sub.2 CH.sub.3                                                                     H    Cl   OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   SO.sub.2 N(CH.sub.3).sub.2                                                            H    CH.sub.3                                                                            CH.sub.3                                                                            N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              H   SO.sub.2 N(CH.sub.3).sub.2                                                            H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   SO.sub.2 N(CH.sub.3).sub.2                                                            H    OCH.sub.3                                                                           OCH.sub.3                                                                           N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              H   SO.sub.2 N(CH.sub.3).sub.2                                                            H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   SCH.sub.3                                                                             H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   SCH.sub.3                                                                             H    CH.sub.3                                                                            CH.sub.3                                                                            Cl                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   SCH.sub.3                                                                             H    OCH.sub.3                                                                           CH.sub.3                                                                            CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   SCH.sub.3                                                                             H    Cl   OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   SO.sub.2 CH.sub.3                                                                     H    CH.sub.3                                                                            CH.sub.3                                                                            CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   SO.sub.2 CH.sub.3                                                                     H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   SO.sub.2 CH.sub.3                                                                     H    CH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              F   F      H    CH.sub.3                                                                            CH.sub.3                                                                            CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              F   F      H    OCH.sub.3                                                                           CH.sub.3                                                                            Cl                               Q-3                                                                               0 H  H    CH.sub.3                                                                              Cl  Cl     H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              Cl  Cl     H    CH.sub.3                                                                            CH.sub.3                                                                            N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              F   Cl     H    OCH.sub.3                                                                           CH.sub.3                                                                            N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              F   CH.sub.3                                                                              H    CH.sub.3                                                                            CH.sub.3                                                                            CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              CH.sub.3                                                                           CH.sub.3                                                                              H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                     H    OCH.sub.3                                                                           OCH.sub.3                                                                           N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              F   Br     H    Cl   OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              Br  Br     H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              CN  CN     H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              CN  CN     H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              CN  CN     H    OCH.sub.3                                                                           OCH.sub.3                                                                           N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              OCH.sub.3                                                                          OCH.sub.3                                                                             H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   H      CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                                                            CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   H      CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   H      OCH.sub.3                                                                           OCH.sub.3                                                                           CH.sub.3                                                                            CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              H   H      CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           CH.sub.3                                                                            N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              F   H      CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              Cl  H      CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                           N                                Q-3                                                                               0 H  H    CH.sub.3                                                                              F   F      CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              Br  H      CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  H    CH.sub.3                                                                              Cl  Cl     CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-3                                                                               0 H  5-CH.sub.3                                                                          CH.sub.3                                                                              H   H      --   OCH.sub.3                                                                           OCH.sub. 3                                                                          N                                Q-3                                                                               0 H  6-OCH.sub.3                                                                         CH.sub.3                                                                              H   H      --   CH.sub.3                                                                            CH.sub.3                                                                            CH                               Q-3                                                                               0 H  3-SCH.sub.3                                                                         CH.sub.3                                                                              H   H      --   CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  5-Cl CH.sub.3                                                                              Cl  H      --   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               0 H  6-Cl CH.sub.2 CH.sub.3                                                                     F   F      CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                                                            N                                Q-3                                                                               0 H  5-OCH.sub.2 F                                                                       CH.sub.2 CH.sub.3                                                                     H   H      H    OCH.sub.3                                                                           OCH.sub.3                                                                           N                                Q-3                                                                               0 CH.sub.3                                                                          H    CH.sub.2 CH.sub.3                                                                     H   H      H    OCH.sub.3                                                                           OCH.sub.3                                                                           N                                Q-3                                                                               0 H  H    CH.sub.2 CH.sub.3                                                                     H   H      H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               1 H  H    CH.sub.3                                                                              F   F      H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-3                                                                               1 H  H    CH.sub.3                                                                              F   Cl     H    CH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-3                                                                               1 H  H    CH.sub.2 CH.sub.3 CH.sub.3                                                            CH.sub.3                                                                           Cl     H    OCH.sub.3                                                                           CH.sub.3                                                                            CH                               Q-3                                                                               1 H  H    CH.sub.3                                                                              F   H      H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-3                                                                               1 H  H    CH.sub.3                                                                              Cl  H      H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               1 H  H    CH.sub.3                                                                              Br  H      H    CH.sub.3                                                                            OCH.sub. 3                                                                          N                                Q-3                                                                               1 H  H    CH.sub.2 CH.sub.3                                                                     Cl  Cl     H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-3                                                                               1 H  H    CH.sub.3                                                                              CH.sub.3                                                                           H      H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-3                                                                               1 H  H    CH.sub.3                                                                              CN  H      H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               1 H  H    CH.sub.3                                                                              CN  CN     H    CH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-3                                                                               1 H  H    CH.sub.3                                                                              CH.sub.3                                                                           Br     H    CH.sub.3                                                                            CH.sub.3                                                                            CH                               Q-3                                                                               1 H  H    CH.sub.3                                                                              F   Br     H    Cl   OCH.sub.3                                                                           CH                               Q-3                                                                               1 H  3-CH.sub.3                                                                          CH.sub.3                                                                              F   H      H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-3                                                                               1 H  5-OCH.sub.3                                                                         CH.sub.3                                                                              Cl  H      CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                                                            N                                Q-3                                                                               1 H  5-Cl CH.sub.3                                                                              Cl  Cl     CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            OCH.sub.3                                                                           N                                __________________________________________________________________________     Q    n  R   R.sub.1                                                                              R.sub.7                                                                             R.sub.8 X     Y     Z    m.p. (°C.)              __________________________________________________________________________     Q-4  0  H   H     H    H       CH.sub.3                                                                             CH.sub.3                                                                             CH   197-199                        Q-4  0  H   H     H    H       CH.sub.3                                                                             OCH.sub.3                                                                            CH   192-194                        Q-4  0  H   H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH   194-196                        Q-4  0  H   H     H    H       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-4  0  H   H     H    H       CH.sub.3                                                                             OCH.sub.3                                                                            N    155-158                        Q-4  0  H   H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            N    150-152                        Q-4  0  H   H     H    H       Cl    OCH.sub.3                                                                            CH   182-184                        Q-4  0  H   H     H    CH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-4  0  H   H     H    CH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-4  0  H   H     H    CH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-4  0  H   H     H    CH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-4  0  H   H     H    Cl      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-4  0  H   H     H    Cl      OCH.sub.3                                                                            CH.sub.3                                                                             N                                   Q-4  0  H   H     H    Cl      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-4  0  H   H     H    Cl      Cl    OCH.sub.3                                                                            CH                                  Q-4  0  H   H     H    F       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-4  0  H   H     H    F       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-4  0  H   H     H    F       OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-4  0  H   H     H    F       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-4  0  H   H     H    F       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-4  0  H   H     H    F       Cl    OCH.sub.3                                                                            CH                                  Q-4  0  H   H     H    CN      CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-4  0  H   H     H    CN      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-4  0  H   H     H    OCH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-4  0  H   H     H    OCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-4  0  H   H     H    OCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-4  0  H   H     H    CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-4  0  H   H     H    CO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-4  0  H   H     H    CO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-4  0  H   H     H    CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-4  0  H   H     H    CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-4  0  H   H     H    CO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-4  0  H   H     H    CO.sub.2 CH.sub.3                                                                      Cl    OCH.sub.3                                                                            CH                                  Q-4  0  H   H     H    OH      CH.sub.3                                                                             CH.sub.3                                                                             CH   148-150                        Q-4  0  H   H     H    OH      CH.sub.3                                                                             OCH.sub.3                                                                            CH   163-164                        Q-4  0  H   H     H    OH      OCH.sub.3                                                                            OCH.sub.3                                                                            CH   133-136                        Q-4  0  H   H     H    OH      CH.sub.3                                                                             OCH.sub.3                                                                            N    165-167                        Q-4  0  H   H     H    OH      OCH.sub.3                                                                            OCH.sub.3                                                                            N    160-162                        Q-4  0  H   H     H    OH      Cl    OCH.sub.3                                                                            CH   138-140                        Q-4  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-4  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-4  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-4  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-4  0  H   H     H    SCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-4  0  H   H     H    SCH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-4  0  H   H     H    SCH.sub.3                                                                              OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-4  0  H   H     H    SCH.sub.3                                                                              Cl    OCH.sub.3                                                                            CH                                  Q-4  0  H   H     H    SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-4  0  H   H     H    SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-4  0  H   H     H    SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-4  0  H   H     F    F       CH.sub. 3                                                                            CH.sub.3                                                                             CH                                  Q-4  0  H   H     F    F       OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-4  0  H   H     Cl   Cl      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-4  0  H   H     Cl   Cl      CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-4  0  H   H     F    Cl      OCH.sub.3                                                                            CH.sub.3                                                                             N                                   Q-4  0  H   H     F    CH.sub.3                                                                               CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-4  0  H   H     CH.sub.3                                                                            CH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-4  0  H   H     CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-4  0  H   H     F    Br      Cl    OCH.sub.3                                                                            CH                                  Q-4  0  H   H     Br   Br      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-4  0  H   H     CN   CN      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-4  0  H   H     CN   CN      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-4  0  H   H     CN   CN      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-4  0  H   H     OCH.sub.3                                                                           OCH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-4  0  H   5-CH.sub.3                                                                           F    H       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-4  0  H   6-CH.sub.3                                                                           Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-4  0  H   H     F    F       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-4  0  H   3-CH.sub.3                                                                           Br   H       OCH.sub.3                                                                            OCH.sub. 3                                                                           CH                                  Q-4  0  H   H     Cl   Cl      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-4  0  H   5-CH.sub.3                                                                           H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-4  0  H   5-OCH.sub.3                                                                          H    H       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-4  0  H   6-SCH.sub.3                                                                          H    H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-4  0  H   5-Cl  Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-4  0  H   3-Cl  F    F       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-4  0  H   5-OCH.sub.2 F                                                                        Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-4  0  CH.sub.3                                                                           H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-4  1  H   H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-4  1  H   H     F    F       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-4  1  H   H     F    Cl      CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-4  1  H   H     CH.sub.3                                                                            Cl      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-4  1  H   H     F    H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-4  1  H   H     Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-4  1  H   H     Br   H       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-4  1  H   H     Cl   Cl      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-4  1  H   H     CH.sub.3                                                                            H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-4  1  H   H     CN   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-4  1  H   H     CN   CN      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-4  1  H   H     CH.sub.3                                                                            Br      CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-4  1  H   H     F    Br      Cl    OCH.sub.3                                                                            CH                                  Q-4  1  H   5-CH.sub.3                                                                           F    H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-4  1  H   5-OCH.sub.3                                                                          Cl   H       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-4  1  H   5-Cl  Cl   Cl      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-5  0  H   H     H    H       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-5  0  H   H     H    H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    H       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-5  0  H   H     H    H       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-5  0  H   H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-5  0  H   H     H    H       Cl    OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    CH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    CH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    CH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-5  0  H   H     H    CH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    Cl      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    Cl      OCH.sub.3                                                                            CH.sub.3                                                                             N                                   Q-5  0  H   H     H    Cl      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    Cl      Cl    OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    F       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-5  0  H   H     H    F       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-5  0  H   H     H    F       OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-5  0  H   H     H    F       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    F       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    F       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-5  0  H   H     H    F       Cl    OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    CN      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-5  0  H   H     H    CN      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    OCH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-5  0  H   H     H    OCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    OCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-5  0  H   H     H    CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-5  0  H   H     H    CO.sub.2 CH.sub.3                                                                      OCH.sub. 3                                                                           CH.sub.3                                                                             CH                                  Q-5  0  H   H     H    CO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-5  0  H   H     H    CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-5  0  H   H     H    CO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-5  0  H   H     H    CO.sub.2 CH.sub.3                                                                      Cl    OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-5  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-5  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    SCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    SCH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                             Cl                                  Q-5  0  H   H     H    SCH.sub.3                                                                              OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-5  0  H   H     H    SCH.sub.3                                                                              Cl    OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-5  0  H   H     H    SO.sub.3 CH.sub.3                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-5  0  H   H     H    SO.sub.3 CH.sub.3                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-5  0  H   H     F    F       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-5  0  H   H     F    F       OCH.sub.3                                                                            CH.sub.3                                                                             N                                   Q-5  0  H   H     Cl   Cl      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   H     Cl   Cl      CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-5  0  H   H     F    Cl      OCH.sub.3                                                                            CH.sub.3                                                                             N                                   Q-5  0  H   H     F    CH.sub.3                                                                               CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-5  0  H   H     CH.sub.3                                                                            CH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   H     CH.sub.3                                                                            CH CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-5  0  H   H     F    Br      Cl    OCH.sub.3                                                                            CH                                  Q-5  0  H   H     Br   Br      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   H     CO.sub.2 CH.sub.3                                                                   CO CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   H     CN   CN      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-5  0  H   H     CN   CN      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   H     CN   CN      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-5  0  H   H     OCH.sub.3                                                                           OCH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-5  0  H   6-CH.sub.3                                                                           CH.sub.3                                                                            CH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   3-CH.sub.3                                                                           CH.sub.3                                                                            H       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-5  0  H   5-CH.sub.3                                                                           F    H       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-5  0  H   5-CH.sub.3                                                                           Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-5  0  H   H     F    F       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-5  0  H   6-CH.sub.3                                                                           Br   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   H     Cl   Cl      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-5  0  H   3-CH.sub.3                                                                           H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-5  0  H   5-OCH.sub.3                                                                          H    H       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-5  0  H   5-SCH.sub.3                                                                          H    H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-5  0  H   5-Cl  Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  0  H   6-Cl  F    F       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-5  0  H   5-OCH.sub.2 F                                                                        Cl   F       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-5  0  CH.sub.3                                                                           H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-5  1  H   H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  1  H   H     F    F       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-5  1  H   H     F    Cl      CH.sub.3                                                                             CH.sub. 3                                                                            N                                   Q-5  1  H   H     CH.sub.3                                                                            Cl      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-5  1  H   H     F    H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-5  1  H   H     Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  1  H   H     Br   H       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-5  1  H   H     Cl   Cl      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-5  1  H   H     CH.sub.3                                                                            H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-5  1  H   H     CN   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  l  H   H     CN   CN      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-5  1  H   H     CH.sub.3                                                                            Br      CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-5  1  H   H     F    Br      Cl    OCH.sub.3                                                                            CH                                  Q-5  1  H   3-CH.sub.3                                                                           F    H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-5  1  H   5-OCH.sub.3                                                                          Cl   H       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-5  1  H   6-Cl  Cl   H       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-6  0  H   H     H    H       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-6  0  H   H     H    H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    H       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-6  0  H   H     H    H       CH.sub. 3                                                                            OCH.sub.3                                                                            N                                   Q-6  0  H   H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-6  0  H   H     H    H       Cl    OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    CH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    CH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    CH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-6  0  H   H     H    CH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    Cl      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    Cl      OCH.sub.3                                                                            CH.sub.3                                                                             N                                   Q-6  0  H   H     H    Cl      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    Cl      Cl    OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    F       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-6  0  H   H     H    F       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-6  0  H   H     H    F       OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-6  0  H   H     H    F       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    F       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-6  0  H   H     H    F       Cl    OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    CN      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-6  0  H   H     H    CN      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    OCH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-6  0  H   H     H    OCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    OCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-6  0  H   H     H    CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-6  0  H   H     H    CO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    CO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-6  0  H   H     H    CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-6  0  H   H     H    CO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-6  0  H   H     H    CO.sub.2 CH.sub.3                                                                      Cl    OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-6  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-6  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    SCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    SCH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-6  0  H   H     H    SCH.sub.3                                                                              OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-6  0  H   H     H    SCH.sub.3                                                                              Cl    OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-6  0  H   H     H    SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-6  0  H   H     H    SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-6  0  H   H     F    F       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-6  0  H   H     F    F       OCH.sub.3                                                                            CH.sub.3                                                                             Cl                                  Q-6  0  H   H     Cl   Cl      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  0  H   H     Cl   Cl      CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-6  0  H   H     F    Cl      OCH.sub.3                                                                            CH.sub.3                                                                             N                                   Q-6  0  H   H     F    CH.sub.3                                                                               CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-6  0  H   H     CH.sub.3                                                                            CH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  0  H   H     CH.sub.3                                                                            CH CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-6  0  H   H     F    Br      Cl    OCH.sub.3                                                                            CH                                  Q-6  0  H   H     Br   Br      OCH.sub. 3                                                                           OCH.sub.3                                                                            CH                                  Q-6  0  H   H     CN   CN      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-6  0  H   H     CN   CN      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  0  H   H     CN   CN      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-6  0  H   H     OCH.sub.3                                                                           OCH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-6  0  H   5-CH.sub.3                                                                           CH.sub.3                                                                            H       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-6  0  H   6-CH.sub.3                                                                           F    H       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-6  0  H   3-CH.sub.3                                                                           Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-6  0  H   H     F    F       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-6  0  H   5-CH.sub.3                                                                           Br   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  0  H   H     Cl   Cl      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-6  0  H   6-CH.sub.3                                                                           H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-6  0  H   5-OCH.sub.3                                                                          H    H       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-6  0  H   5-SCH.sub.3                                                                          H    H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-6  0  H   5-Cl  Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  0  H   3-Cl  F    F       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-6  0  H   5-OC.sub.2 F                                                                         Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-6  0  CH.sub.3                                                                           H     H    H       OCH.sub. 3                                                                           OCH.sub.3                                                                            N                                   Q-6  1  H   H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  1  H   H     F    F       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-6  1  H   H     F    Cl      CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-6  1  H   H     CH.sub.3                                                                            Cl      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-6  1  H   H     F    H       CH.sub.3                                                                             OCH.sub.3                                                                            HH                                  Q-6  1  H   H     Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  1  H   H     Br   H       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-6  1  H   H     Cl   Cl      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-6  1  H   H     CH.sub.3                                                                            H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-6  1  H   H     CN   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  1  H   H     CN   CN      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-6  1  H   H     CH.sub.3                                                                            Br      CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-6  1  H   H     F    Br      Cl    OCH.sub.3                                                                            CH                                  Q-6  1  H   3-CH.sub.3                                                                           F    H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-6  1  H   3-OCH.sub.3                                                                          Cl   H       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-6  1  H   5-Cl  Cl   Cl      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-7  0  H   H     H    H       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-7  0  H   H     H    H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    H       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-7  0  H   H     H    H       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-7  0  H   H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-7  0  H   H     H    H       Cl    OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    CH.sub.3                                                                               CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-7  0  H   H     H    CH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    CH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-7  0  H   H     H    CH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    Cl      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    Cl      OCH.sub.3                                                                            CH.sub.3                                                                             N                                   Q-7  0  H   H     H    Cl      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    Cl      Cl    OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    F       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-7  0  H   H     H    F       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-7  0  H   H     H    F       OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-7  0  H   H     H    F       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    F       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-7  0  H   H     H    F       Cl    OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    CN      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-7  0  H   H     H    CN      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    OCH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-7  0  H   H     H    OCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    OCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-7  0  H   H     H    CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-7  0  H   H     H    CO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-7  0  H   H     H    CO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-7  0  H   H     H    CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-7  0  H   H     H    CO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-7  0  H   H     H    CO.sub.2 CH.sub.3                                                                      Cl    OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-7  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-7  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    SCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    SCH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                             Cl                                  Q-7  0  H   H     H    SCH.sub.3                                                                              OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-7  0  H   H     H    SCH.sub.3                                                                              Cl    OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-7  0  H   H     H    SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-7  0  H   H     H    SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-7  0  H   H     F    F       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-7  0  H   H     F    F       OCH.sub.3                                                                            CH.sub.3                                                                             Cl                                  Q-7  0  H   H     Cl   Cl      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  0  H   H     Cl   Cl      CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-7  0  H   H     F    Cl      OCH.sub.3                                                                            CH.sub.3                                                                             N                                   Q-7  0  H   H     F    CH.sub.3                                                                               CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-7  0  H   H     CH.sub.3                                                                            CH.sub.3                                                                               OCH.sub. 3                                                                           OCH.sub.3                                                                            CH                                  Q-7  0  H   H     CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-7  0  H   H     F    Br      Cl    OCH.sub.3                                                                            CH                                  Q-7  0  H   H     Br   Br      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  0  H   H     CN   CN      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-7  0  H   H     CN   CN      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  0  H   H     CN   CN      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-7  0  H   H     OCH.sub.3                                                                           OCH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-7  0  H   3-CH.sub.3                                                                           CH.sub.3                                                                            H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-7  0  H   5-CH.sub.3                                                                           CH.sub.3                                                                            H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  0  CH.sub.3                                                                           H     CH.sub.3                                                                            H       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-7  0  CH.sub.3                                                                           H     F    H       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-7  0  H   5-CH.sub.3                                                                           Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-7  0  H   H     F    F       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-7  0  H   H     Br   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  0  H   H     Cl   Cl      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-7  0  H   5-CH.sub.3                                                                           H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-7  0  H   6-OCH.sub.3                                                                          H    H       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-7  0  H   5-SCH.sub.3                                                                          H    H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-7  0  H   3-Cl  Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  0  H   5-Cl  F    F       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-7  0  H   3-OCH.sub.2 F                                                                        Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-7  0  CH.sub.3                                                                           H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-7  1  H   H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  1  H   H     F    F       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-7  1  H   H     F    Cl      CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-7  1  H   H     CH.sub.3                                                                            Cl      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-7  1  H   H     F    H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-7  1  H   H     Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  1  H   H     Br   H       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-7  1  H   H     Cl   Cl      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-7  1  H   H     CH.sub.3                                                                            H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-7  1  H   H     CN   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  1  H   H     CN   CN      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-7  1  H   H     CH.sub.3                                                                            Br      CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-7  1  H   H     F    Br      Cl    OCH.sub.3                                                                            CH                                  Q-7  1  H   5-CH.sub.3                                                                           F    H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-7  1  H   5-OCH.sub.3                                                                          Cl   H       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-7  1  H   5-Cl  Cl   H       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-8  0  H   H     H    H       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-8  0  H   H     H    H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    H       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-8  0  H   H     H    H       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-8  0  H   H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-8  0  H   H     H    H       Cl    OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    CH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    CH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    CH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-8  0  H   H     H    CH.sub.3                                                                               CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-8  0  H   H     H    Cl      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    Cl      OCH.sub.3                                                                            CH.sub.3                                                                             N                                   Q-8  0  H   H     H    Cl      OCH.sub.3                                                                            OCH.sub.3                                                                            CH.sub. 3                           Q-8  0  H   H     H    Cl      Cl    OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    F       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-8  0  H   H     H    F       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-8  0  H   H     H    F       OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-8  0  H   H     H    F       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    F       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-8  0  H   H     H    F       Cl    OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    CN      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-8  0  H   H     H    CN      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    OCH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-8  0  H   H     H    OCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    OCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-8  0  H   H     H    CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-8  0  H   H     H    CO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-8  0  H   H     H    CO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-8  0  H   H     H    CO.sub.2 CH.sub.3                                                                      CH.sub. 3                                                                            CH.sub.3                                                                             CH                                  Q-8  0  H   H     H    CO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-8  0  H   H     H    CO.sub.2 CH.sub.3                                                                      Cl    OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-8  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-8  0  H   H     H    SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    SCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    SCH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-8  0  H   H     H    SCH.sub.3                                                                              OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-8  0  H   H     H    SCH.sub.3                                                                              Cl    OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-8  0  H   H     H    SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-8  0  H   H     F    F       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-8  0  H   H     F    F       OCH.sub.3                                                                            CH.sub.3                                                                             Cl                                  Q-8  0  H   H     Cl   Cl      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  0  H   H     Cl   Cl      CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-8  0  H   H     F    Cl      OCH.sub.3                                                                            CH.sub.3                                                                             N                                   Q-8  0  H   H     F    CH.sub.3                                                                               CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-8  0  H   H     CH.sub.3                                                                            CH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  0  H   H     CH.sub.3                                                                            CH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-8  0  H   H     F    Br      Cl    OCH.sub.3                                                                            CH                                  Q-8  0  H   H     Br   Br      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  0  H   H     CN   CN      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-8  0  H   H     CN   CN      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  0  H   H     CN   CN      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-8  0  H   H     OCH.sub.3                                                                           OCH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    Br      CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-8  0  H   H     H    Br      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-8  0  H   H     H    Br      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  0  H   3-CH.sub.3                                                                           CH.sub.3                                                                            H       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-8  0  H   5-CH.sub.3                                                                           F    H       CH.sub.3                                                                             OCH.sub. 3                                                                           N                                   Q-8  0  H   H     Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-8  0  H   H     F    F       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-8  0  H   H     Br   H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-8  0  H   H     Cl   Cl      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-8  0  H   5-CH.sub.3                                                                           H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-8  0  H   5-OCH.sub.3                                                                          H    H       CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-8  0  H   5-SCH.sub.3                                                                          H    H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-8  0  H   5-Cl  Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  0  H   6-Cl  F    F       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-8  0  H   5-OCH.sub.2 F                                                                        Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-8  0  CH.sub.3                                                                           H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            N                                   Q-8  1  H   H     H    H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  1  H   H     F    F       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-8  1  H   H     F    Cl      CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-8  1  H   H     CH.sub.3                                                                            Cl      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                  Q-8  1  H   H     F    H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-8  1  H   H     Cl   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  1  H   H     Br   H       CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-8  1  H   H     Cl   Cl      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-8  1  H   H     CH.sub.3                                                                            H       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  Q-8  1  H   H     CN   H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  1  H   H     CN   CN      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   Q-8  1  H   H     CH.sub.3                                                                            Br      CH.sub.3                                                                             CH.sub.3                                                                             CH                                  Q-8  1  H   H     F    Br      Cl    OCH.sub.3                                                                            CH                                  Q-8  1  H   5-CH.sub.3                                                                           F    H       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  Q-8  1  H   3-OCH.sub.3                                                                          Cl   H       CH.sub.3                                                                             CH.sub.3                                                                             N                                   Q-8  1  H   5-Cl  Cl   Cl      CH.sub.3                                                                             OCH.sub.3                                                                            N                                   __________________________________________________________________________     Q  n  R   R.sub.1                                                                             R.sub.3                                                                             R.sub.7                                                                             R.sub.8                                                                               X     Y     Z   m.p. (°C.)              __________________________________________________________________________     Q-9                                                                               0  H   H    CH.sub.3                                                                            H    H      CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    H      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    H      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    H      CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            H    H      CH.sub. 3                                                                            OCH.sub.3                                                                            N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            H    H      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            H    H      Cl    OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    Cl     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                            CH.sub.3                                                                             N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    Cl     Cl    OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    F      CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            H    F      CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    F      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    F      OCH.sub.3                                                                            OCH.sub. 3                                                                           CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    F      CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            H    F      Cl    OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    CN     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            H    CN     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            H    CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            H    CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            H    CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            H    CO.sub.2 CH.sub.3                                                                     Cl    OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    SO.sub.2 N(CH.sub.3).sub.2                                                            CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            H    SO.sub.2 N(CH.sub.3).sub.2                                                            OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    SO.sub.2 N(CH.sub.3).sub.2                                                            OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            H    SO.sub.2 N(CH.sub.3).sub.2                                                            CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    SCH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    SCH.sub.3                                                                             CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    SCH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    SCH.sub.3                                                                             Cl    OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    SO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    SO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    SO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            F    F      CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            F    F      OCH.sub.3                                                                            CH.sub.3                                                                             Cl                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            Cl   Cl     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            Cl   Cl     CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            F    Cl     OCH.sub.3                                                                            CH.sub.3                                                                             N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            F    CH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            CH.sub.3                                                                            CH     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            F    Br     Cl    OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            Br   Br     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            CN   CN     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            CN   CN     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            CN   CN     OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    Br     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    Br     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    Br     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            H    H      CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            F    H      CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            Cl   H      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            F    F      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   H    CH.sub.3                                                                            Br   H      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-9                                                                               0  H   H    CH.sub.3                                                                            Cl   Cl     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-9                                                                               0  H   5-SCH.sub.3                                                                         CH.sub.3                                                                            H    H      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   5-Cl CH.sub.3                                                                            Cl   H      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-9                                                                               0  H   5-Cl CH.sub.3                                                                            F    F      CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-9                                                                               0  H   5-OCH.sub.2 F                                                                       CH.sub.3                                                                            Cl   H      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-9                                                                               0  CH.sub.3                                                                           H    CH.sub.3                                                                            H    H      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-9                                                                               1  H   H    CH.sub.3                                                                            H    H      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-9                                                                               1  H   H    CH.sub.3                                                                            F    F      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-9                                                                               1  H   H    CH.sub.3                                                                            F    Cl     CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-9                                                                               1  H   H    CH.sub.3                                                                            CH.sub.3                                                                            Cl     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 Q-9                                                                               1  H   H    CH.sub.3                                                                            F    H      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-9                                                                               1  H   H    CH.sub.3                                                                            Cl   H      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-9                                                                               1  H   H    H    Br   H      CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-9                                                                               1  H   H    H    Cl   Cl     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-9                                                                               1  H   H    H    CH.sub.3                                                                            H      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-9                                                                               1  H   H    H    CN   H      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-9                                                                               1  H   H    H    CN   CN     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-9                                                                               1  H   H    H    CH.sub.3                                                                            Br     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-9                                                                               1  H   H    H    F    Br     Cl    OCH.sub.3                                                                            CH                                 Q-9                                                                               1  H   3-CH.sub.3                                                                          H    F    H      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-9                                                                               1  H   6-OCH.sub.3                                                                         CH.sub.3                                                                            Cl   H      CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-9                                                                               1  H   5-Cl CH.sub.2 CH.sub.3                                                                   Cl   Cl     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            H    H      CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    H      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    H      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    H      CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            H    H      CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            H    H      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            H    H      Cl    OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            H    CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                            CH.sub.3                                                                             N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            H    Cl     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    Cl     Cl    OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    F      CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            H    F      CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    F      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    F      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    F      CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            H    F      Cl    OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    CN     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            H    CN     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    OCH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    OCH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            H    CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            H    CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            H    CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            H    CO.sub.2 CH.sub.3                                                                     Cl    OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    SO.sub.2 N(CH.sub.3).sub.2                                                            CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            H    SO.sub.2 N(CH.sub.3).sub.2                                                            OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    SO.sub.2 N(CH.sub.3).sub.2                                                            OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            H    SO.sub.2 N(CH.sub.3).sub.2                                                            CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    SCH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    SCH.sub.3                                                                             CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    SCH.sub.3                                                                             OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    SCH.sub.3                                                                             Cl    OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    SO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    SO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            H    SO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            F    F      CH.sub.3                                                                             CH.sub. 3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            F    F      OCH.sub.3                                                                            CH.sub.3                                                                             Cl                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            Cl   Cl     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            Cl   Cl     CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            F    Cl     OCH.sub.3                                                                            CH.sub.3                                                                             N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            F    CH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                            H                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            F    Br     Cl    OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            Br   Br     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            CN   CN     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            CN   CN     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            CN   CN     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-10                                                                              0  H   H    CH.sub.3                                                                            CN   CN     OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-10                                                                              0  H   H    CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                             CH    OCH.sub.3                                                                            CH                                 __________________________________________________________________________                                                       m.p.                         Q   n  R   R.sub.1                                                                              R.sub.7                                                                            R.sub.8                                                                           R.sub.3    X     Y    Z   (°C.)                 __________________________________________________________________________     Q-10                                                                               0  H   H     H   Br CH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                            CH                               Q-10                                                                               0  H   H     H   Br CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                           CH                               Q-10                                                                               0  H   H     H   Br CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-10                                                                               0  H   H     H   H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       OCH.sub.3                                                                            CH.sub.3                                                                            N                                Q-10                                                                               0  H   5-CH.sub.3                                                                           F   H  CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                           N                                Q-10                                                                               0  H   H     Cl  H  CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-10                                                                               0  H   H     F   F  CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                           CH                               Q-10                                                                               0  H   H     Br  H  CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-10                                                                               0  H   H     Cl  Cl CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                           N                                Q-10                                                                               0  H   6-CH.sub.3                                                                           H   H  CH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub. 3                                                                           OCH.sub.3                                                                           N                                Q-10                                                                               0  H   5-OCH.sub.3                                                                          H   H  CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                            CH                               Q-10                                                                               0  H   3-SCH.sub.3                                                                          H   H  CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                           CH                               Q-10                                                                               0  H   6-Cl  Cl  H  CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                           CH                               Q-10                                                                               0  H   5-Cl  F   F  CH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                            N                                Q-10                                                                               0  H   5-OCH.sub.2 F                                                                        Cl  H  CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-10                                                                               0  CH.sub.3                                                                           H     H   H  H          OCH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-10                                                                               1  H   H     H   H  H          OCH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-10                                                                               1  H   H     F   F  H          CH.sub.3                                                                             OCH.sub.3                                                                           CH                               Q-10                                                                               1  H   H     F   Cl CH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                            N                                Q-10                                                                               1  H   H     CH  Cl H          OCH.sub.3                                                                            CH.sub.3                                                                            CH                               Q-10                                                                               1  H   H     F   H  H          CH.sub.3                                                                             OCH.sub.3                                                                           CH                               Q-10                                                                               1  H   H     Cl  H  CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-10                                                                               1  H   H     Br  H  H          CH.sub.3                                                                             OCH.sub.3                                                                           N                                Q-10                                                                               1  H   H     Cl  Cl CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                           CH                               Q-10                                                                               1  H   H     CH.sub.3                                                                           H  CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                           CH                               Q-10                                                                               1  H   H     CN  H  CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-10                                                                               1  H   H     CN  CN H          CH.sub.3                                                                             OCH.sub.3                                                                           N                                Q-10                                                                               1  H   H     CH.sub.3                                                                           Br H          CH.sub.3                                                                             CH.sub.3                                                                            CH                               Q-10                                                                               1  H   H     F   Br CH.sub.3   Cl    OCH.sub.3                                                                           CH                               Q-10                                                                               1  H   3-CH.sub.3                                                                           F   H  H          OCH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-10                                                                               1  H   5-OCH.sub.3                                                                          Cl  H  CH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                            N                                Q-10                                                                               1  H   6-Cl  Cl  Cl CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                           N                                __________________________________________________________________________     Q  n  R R.sub.1                                                                          R.sub.3                                                                           R.sub.7                                                                           R.sub.8                                                                          R.sub.9                                                                          R.sub.10                                                                          R.sub.11                                                                          X        Y         Z   m.p. (°C.)             __________________________________________________________________________     Q-1                                                                               0  H H -- H  H H H  -- NHCH.sub.3                                                                              OCH.sub.2 CH.sub.3                                                                       N   203-206                       Q-1                                                                               0  H H -- H  H H H  -- CH.sub.3 SCH.sub.3 CH                                Q-1                                                                               0  H H -- H  H Cl                                                                               H  -- N(CH.sub.3)H                                                                            OCH.sub.2 CH.sub.3                                                                       N   154-158                       Q-1                                                                               0  H H -- Cl Cl                                                                               H H  -- OCH.sub.3                                                                               CH(OCH.sub.3).sub.2                                                                      CH                                Q-1                                                                               0  H H -- CH.sub.3                                                                          H H H  -- OCH.sub.3                                                                               OCH.sub.2 CHCH.sub.2                                                                     CH                                Q-1                                                                               0  H H -- CH.sub.3                                                                          H H Cl -- OCH.sub.3                                                                               OCH.sub.2 CH.sub.3                                                                       CH                                Q-1                                                                               0  H H -- F  F H H  -- OCH.sub.2 CH.sub.3                                                                      OCH.sub.2 F                                                                              N                                 Q-1                                                                               0  H H -- H  CN                                                                               H H  -- OCH.sub.3                                                                               SCH.sub.3 CH                                Q-1                                                                               0  H Cl                                                                               -- Br H H CH.sub.3                                                                          -- OCH.sub.3                                                                               Br        CH                                Q-1                                                                               0  H H -- H  Br                                                                               H H  -- OCH.sub.3                                                                               NH.sub.2  CH                                Q-1                                                                               0  H H -- H  Br                                                                               Cl                                                                               H  -- OCH.sub.3                                                                               NHCH.sub.2                                                                               N                                 Q-1                                                                               0  H H -- F  F Cl                                                                               F  -- CH.sub.3 OCH.sub.2 C CH                                                                           CH                                Q-1                                                                               0  H H -- F  CN                                                                               H H  -- OCH.sub.3                                                                               CH.sub.2 CF.sub.3                                                                        CH                                Q-1                                                                               0  H H -- H  H H H  -- OCF.sub.2 CH.sub.3                                                                      CH.sub.3  N                                 Q-1                                                                               0  H H -- H  H H H  -- OCH.sub.3                                                                               CCH       CH                                 Q-1                                                                               0  H                                                                                H                                                                                --                                                                                Cl                                                                                Cl                                                                               H                                                                                H  --                                                                                OCH.sub.3                                                                               ##STR51##                                                                                CH                               Q-2                                                                               0  H H -- H  H H H  H  OCH.sub.3                                                                               OCH.sub.2 CH.sub.3                                                                       N                                 Q-2                                                                               0  H H -- Cl H H H  H  CH.sub.3 OCH.sub.3                                                                      CH.sub.2 CF.sub.3                                                                        N                                 Q-2                                                                               0  H H -- Cl H CH                                                                               H  H  OCH.sub.3                                                                               N(CH.sub.3).sub.2                                                                        N                                 Q-4                                                                               0  H H -- H  H H H  -- CH.sub.3 CH.sub.2 CH.sub.3                                                                        CH                                Q-4                                                                               0  H H -- H  H H H  -- OCH.sub.3                                                                               OCH.sub.2 OCH.sub.3                                                                      CH                                Q-5                                                                               0  H H -- Cl H H H  -- OCH.sub.3                                                                               SCH.sub.2 CH.sub.3                                                                       CH                                Q-5                                                                               0  H H -- Cl Cl                                                                               H H  -- OCF.sub.2 H                                                                             CH.sub.2 CH.sub.3                                                                        CH                                Q-5                                                                               0  H H -- CH H H CH.sub.3                                                                          -- OCH.sub.3                                                                               F         CH                                Q-9                                                                               0  H H CH.sub.3                                                                          H  H H H  -- SCH.sub.2 CH.sub.2 F                                                                    HNCH.sub.3                                                                               CH                                Q-9                                                                               0  H H H  H  H H F  -- OCH.sub.3                                                                               OCH.sub.2 CHCH.sub.2                                                                     CH                                Q-3                                                                               0  H H CH.sub.3                                                                          H  H H H  H  OCH.sub.2 CH.sub.3                                                                      SCH.sub.2 CH.sub.3                                                                       N                                 Q-3                                                                               0  H H CH.sub.3                                                                          F  H H Br CH.sub.3                                                                          OCH.sub.3                                                                               I         CH                                Q-3                                                                               0  H H H  H  H H H  H  OCH.sub.2 OCH.sub.2 CH.sub.3                                                            CH.sub.3  CH                                Q-7                                                                               0  H H -- H  H H H  -- OCH.sub.2 OCH.sub.2 CH.sub.3                                                            OCH.sub.3 N                                 Q-7                                                                               0  H H -- H  H H H  -- OCHF.sub.2                                                                              N(CH.sub.3).sub.2                                                                        CH                                Q-7                                                                               0  H H -- Cl H H H  -- OCH.sub.3                                                                               N(OCH.sub.3)CH.sub.3                                                                     N                                 __________________________________________________________________________     General Structure I (wherein R.sub.12 and R.sub.13 are H) (W = S)                                                                m.p.                         Q  n  R R.sub.1                                                                             R.sub.7                                                                             R.sub.8                                                                               R.sub.9                                                                           R.sub.10                                                                          R.sub.11                                                                            X    Y    Z   (°C.)                 __________________________________________________________________________     Q-1                                                                               0  H H    H    H      H  H  --   CH.sub.3                                                                            CH.sub.3                                                                            CH                               Q-1                                                                               0  H H    H    H      H  H  --   CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-1                                                                               0  H H    H    H      H  H  --   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-1                                                                               0  H 5-CH.sub.3                                                                          H    H      H  H  --   CH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-1                                                                               0  H H    H    H      H  H  --   CH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-1                                                                               0  H H    H    H      H  H  --   OCH.sub.3                                                                           OCH.sub.3                                                                           N                                Q-1                                                                               0  H H    H    H      H  H  --   Cl   OCH.sub.3                                                                           CH                               Q-1                                                                               0  H H    H    F      H  H  --   CH.sub.3                                                                            CH.sub.3                                                                            CH                               Q-1                                                                               0  H H    H    F      H  H  --   CH.sub.3                                                                            CH.sub.3                                                                            N                                Q-1                                                                               0  H H    H    F      H  H  --   CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-1                                                                               0  H H    H    Cl     H  H  --   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-1                                                                               0  H H    H    Cl     H  H  --   CH.sub.3                                                                            CH.sub.3                                                                            N                                Q-1                                                                               0  H H    Cl   H      H  H  --   CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-1                                                                               0  H H    Cl   H      H  H  --   CH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-1                                                                               0  H H    H    Br     H  H  --   CH.sub.3                                                                            CH.sub.3                                                                            CH                               Q-1                                                                               0  H H    Br   H      H  H  --   CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-1                                                                               0  H H    Br   H      H  H  --   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-1                                                                               0  H H    H    I      H  H  --   CH.sub.3                                                                            CH.sub.3                                                                            N                                Q-1                                                                               0  H H    I    H      H  H  --   CH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-1                                                                               0  H H    H    CN     H  H  --   OCH.sub.3                                                                           OCH.sub.3                                                                           N                                Q-1                                                                               0  H H    CN   H      H  H  --   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-1                                                                               0  H H    H    CH.sub.3                                                                              H  H  --   CH.sub.3                                                                            CH.sub.3                                                                            CH                               Q-1                                                                               0  H H    H    CH.sub.3                                                                              H  H  --   CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-1                                                                               0  H H    H    CH.sub.3                                                                              H  H  --   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-1                                                                               0  H H    CH.sub.3                                                                            H      H  H  --   Cl   OCH.sub.3                                                                           N                                Q-1                                                                               0  H H    CH.sub.3                                                                            H      H  H  --   CH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-1                                                                               0  H H    H    CH.sub.2 CH.sub.3                                                                     H  H  --   OCH.sub.3                                                                           OCH.sub.3                                                                           N                                Q-1                                                                               0  H H    CH.sub.2 CH.sub.3                                                                   H      H  H  --   CH.sub.3                                                                            OCH.sub.3                                                                           CH                               Q-1                                                                               0  H H    H    CH.sub.2 CH.sub.3                                                                     H  H  --   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               Q-1                                                                               0  H H    H    CH.sub.2 CH.sub.2 CH.sub.3                                                            H  H  --   CH.sub.3                                                                            OCH.sub.3                                                                           N                                Q-1                                                                               0  H H    H    Cl     H  H  --   CH.sub.3                                                                            CH.sub.3                                                                            CH                               Q-1                                                                               0  H H    H    Cl     H  H  --   OCH.sub.3                                                                           OCH.sub.3                                                                           N                                Q-1                                                                               0  H H    H    Cl     H  H  --   Cl   OCH.sub.3                                                                           CH                               __________________________________________________________________________

                                      TABLE IA                                     __________________________________________________________________________     General Structure I (wherein R.sub.12 is OH; R.sub.13 is H)                    Q  n R R.sub.1                                                                           R.sub.7                                                                            R.sub.8                                                                               R.sub.9                                                                           R.sub.10                                                                          R.sub.11                                                                           X   Y   Z  m.p. (°C.)                    __________________________________________________________________________     Q-1                                                                               1 H H  H   H      H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           CH 148-150                              Q-1                                                                               1 H H  H   H      H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          CH 140-142                              Q-1                                                                               1 H H  H   H      H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH 148-150                              Q-1                                                                               1 H H  H   H      H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           N                                       Q-1                                                                               1 H H  H   H      H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          N  109-111                              Q-1                                                                               1 H H  H   H      H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          N  147-149                              Q-1                                                                               1 H H  H   H      H  H  --  Cl  OCH.sub.3                                                                          CH 124-126                              Q-1                                                                               1 H H  H   F      H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      Q-1                                                                               1 H H  H   F      H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           N                                       Q-1                                                                               1 H H  H   F      H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   Cl     H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   Cl     H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           N                                       Q-1                                                                               1 H H  Cl  H      H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  Cl  H      H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   Br     H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      Q-1                                                                               1 H H  Br  H      H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  Br  H      H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   I      H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           N                                       Q-1                                                                               1 H H  I   H      H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   CN     H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  CN  H      H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   CH.sub.3                                                                              H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      Q-1                                                                               1 H H  H   CH.sub.3                                                                              H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   CH.sub.3                                                                              H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  CH.sub.3                                                                           H      H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           N                                       Q-1                                                                               1 H H  CH.sub.3                                                                           H      H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   CH.sub.2 CH.sub.3                                                                     H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   CH.sub.2 CH.sub.3                                                                     H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   CH.sub.2 CH.sub.2 CH.sub.3                                                            H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   OCH.sub.3                                                                             H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      Q-1                                                                               1 H H  H   OCH.sub.3                                                                             H  H  --  OCH.sub.3                                                                          CH.sub.3                                                                           CH                                      Q-1                                                                               1 H H  CH.sub.3 O                                                                         H      H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   OCH.sub.2 CH.sub.3                                                                    H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           N                                       Q-1                                                                               1 H H  H   CO.sub. 2 CH.sub.3                                                                    H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   CO.sub.2 CH.sub.3                                                                     H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   CO.sub.2 CH.sub.3                                                                     H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   CO.sub.2 CH.sub.3                                                                     H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   CO.sub.2 CH.sub.2 CH.sub.3                                                            H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   SO.sub.2 N(CH.sub.3).sub.2                                                            H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   SO.sub.2 N(CH.sub.3).sub.2                                                            H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      Q-1                                                                               1 H H  H   SCH.sub.3                                                                             H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   SCH.sub.3                                                                             H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           N                                       Q-1                                                                               1 H H  H   SO.sub.2 CH.sub.3                                                                     H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   SO.sub.2 CH.sub.3                                                                     H  H  --  Cl  OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   SO.sub.2 CH.sub.3                                                                     H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   SO.sub.2 CH.sub.2 CH.sub.3                                                            H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   CH.sub.3                                                                              H  CH.sub.3                                                                          --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   CH.sub.3                                                                              H  CH.sub.3                                                                          --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   CH.sub.3                                                                              CH.sub.3                                                                          H  --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      Q-1                                                                               1 H H  H   CH.sub.3                                                                              H  F  --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   CH.sub.3                                                                              H  F  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   CH.sub.3                                                                              H  F  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   CH.sub.3                                                                              H  Cl --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   CH.sub.3                                                                              Br H  --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   F      H  CH.sub.3                                                                          --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   F      H  CH.sub.3                                                                          --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   Cl     H  CH.sub.3                                                                          --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   Cl     H  F  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   Cl     H  Cl --  Cl  OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   Cl     H  Cl --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   Cl     H  Br --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   SO.sub.2 CH.sub.3                                                                     H  CH.sub.3                                                                          --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      Q-1                                                                               1 H H  H   SO.sub.2 CH.sub.3                                                                     H  CH.sub.3                                                                          --  OCH.sub.3                                                                          CH.sub.3                                                                           CH                                      Q-1                                                                               1 H H  H   SO.sub.2 CH.sub.3                                                                     H  CH.sub.3                                                                          --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   SO.sub.2 CH.sub.3                                                                     H  CH.sub.3                                                                          --  CH.sub.3                                                                           CH.sub.3                                                                           N                                       Q-1                                                                               1 H H  H   SO.sub.2 CH.sub.3                                                                     H  CH.sub.3                                                                          --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   SO.sub.2 CH.sub.3                                                                     H  CH.sub.3                                                                          --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   SO.sub.2 CH.sub.3                                                                     H  CH.sub.3                                                                          --  Cl  OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  H   SO.sub.2 CH.sub.3                                                                     H  Cl --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   SO.sub.2 CH.sub.3                                                                     H  Cl --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   SO.sub.2 CH.sub.3                                                                     H  F  --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  H   SO.sub.2 CH.sub.3                                                                     H  Br --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      Q-1                                                                               1 H H  F   F      H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  F   F      H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  F   F      H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           N                                       Q-1                                                                               1 H H  F   F      H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  F   F      H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  F   F      H  H  --  Cl  OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  Cl  Cl     H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  Cl  Cl     H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  Cl  Cl     H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  Cl  Cl     H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  Cl  Cl     H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      Q-1                                                                               1 H H  Cl  Cl     H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           N                                       Q-1                                                                               1 H H  Cl  Cl     H  H  --  Cl  OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  Br  Br     H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  Br  Br     H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  Br  Br     H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  Br  Br     H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  Br  Br     H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           N                                       Q-1                                                                               1 H H  I   I      H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  CN  CN     H  H  --  Cl  OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  CN  CN     H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  CN  CN     H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  F   F      H  CH.sub.3                                                                          --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      Q-1                                                                               1 H H  F   F      H  CH.sub.3                                                                          --  OCH.sub.3                                                                          CH.sub.3                                                                           CH                                      Q-1                                                                               1 H H  F   F      H  F  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  F   F      H  Cl --  CH.sub.3                                                                           CH.sub.3                                                                           N                                       Q-1                                                                               1 H H  F   F      H  Br --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  Cl  Cl     H  CH.sub.3                                                                          --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  Cl  Cl     H  CH.sub.3                                                                          --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  Cl  Cl     H  Cl --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  Cl  Cl     H  F  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  Cl  Cl     H  Br --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  Br  Br     H  CH.sub.3                                                                          --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      Q-1                                                                               1 H H  Br  Br     H  CH.sub.3                                                                          --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  Br  Br     H  Cl --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  Br  Br     H  Cl --  CH.sub.3                                                                           CH.sub.3                                                                           N                                       Q-1                                                                               1 H H  Br  Br     Cl H  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  Br  Br     H  F  --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  Br  Br     H  Br --  Cl  OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  CN  CN     H  CH.sub.3                                                                          --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  CN  CN     H  CH.sub.3                                                                          --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  CN  CN     H  F  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  CH.sub.3                                                                           CH.sub.3                                                                              H  CH.sub.3                                                                          --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       Q-1                                                                               1 H H  CH.sub.3                                                                           CH.sub.3                                                                              H  CH.sub.3                                                                          --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      Q-1                                                                               1 H H  CH.sub.3                                                                           CH.sub.3                                                                              H  CH.sub.3                                                                          --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      Q-1                                                                               1 H H  CH.sub.3                                                                           CH.sub.3                                                                              CH.sub.3                                                                          H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      __________________________________________________________________________

                                      TABLE IB                                     __________________________________________________________________________     General Structure I (wherein R.sub.12 is OH; R.sub.13 is CH.sub.3)             Q  n R R.sub.1                                                                           R.sub.7                                                                           R.sub.8                                                                           R.sub.9                                                                          R.sub.10                                                                          R.sub.11                                                                          X   Y   Z  m.p. (°C.)                           __________________________________________________________________________     Q-1                                                                               1 H H  H  H  H H  -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                             Q-1                                                                               1 H H  H  H  H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                             Q-1                                                                               1 H H  H  H  H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                             Q-1                                                                               1 H H  H  H  H H  -- CH.sub.3                                                                           CH.sub.3                                                                           N                                              Q-1                                                                               1 H H  H  H  H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                              Q-1                                                                               1 H H  H  H  H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                              Q-1                                                                               1 H H  H  H  H H  -- Cl  OCH.sub.3                                                                          CH                                             Q-1                                                                               1 H H  H  F  H H  -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                             Q-1                                                                               1 H H  H  F  H H  -- CH.sub. 3                                                                          CH.sub.3                                                                           N                                              Q-1                                                                               1 H H  H  F  H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                             Q-1                                                                               1 H H  H  Cl H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                             Q-1                                                                               1 H H  H  Cl H H  -- CH.sub.3                                                                           CH.sub.3                                                                           N                                              Q-1                                                                               1 H H  Cl H  H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                             Q-1                                                                               1 H H  Cl H  H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                              Q-1                                                                               1 H H  H  Br H H  -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                             Q-1                                                                               1 H H  Br H  H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                             Q-1                                                                               1 H H  Br H  H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                             Q-1                                                                               1 H H  H  I  H H  -- CH.sub.3                                                                           CH.sub.3                                                                           N                                              Q-1                                                                               1 H H  I  H  H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                              Q-1                                                                               1 H H  H  CN H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                              Q-1                                                                               1 H H  CN H  H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                             Q-1                                                                               1 H H  H  CH.sub.3                                                                          H H  -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                             __________________________________________________________________________

                                      TABLE IC                                     __________________________________________________________________________     General Structure I (wherein R.sub.12 is OCH.sub.3 ; R.sub.13 is H)            Q  n R R.sub.1                                                                           R.sub.7                                                                           R.sub.8                                                                           R.sub.9                                                                          R.sub.10                                                                          R.sub.11                                                                          X  Y   Z   m.p. (°C.)                           __________________________________________________________________________     Q-1                                                                               1 H H  H  H  H H  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                              Q-1                                                                               1 H H  H  H  H H  -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                              Q-1                                                                               1 H H  H  H  H H  -- OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                              Q-1                                                                               1 H H  H  H  H H  -- CH.sub.3                                                                          CH.sub.3                                                                           N                                               Q-1                                                                               1 H H  H  H  H H  -- CH.sub.3                                                                          OCH.sub.3                                                                          N                                               Q-1                                                                               1 H H  H  H  H H  -- OCH.sub.3                                                                         OCH.sub.3                                                                          N                                               Q-1                                                                               1 H H  H  H  H H  -- Cl OCH.sub.3                                                                          CH                                              Q-1                                                                               1 H H  H  F  H H  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                              Q-1                                                                               1 H H  H  F  H H  -- CH.sub. 3                                                                         CH.sub.3                                                                           N                                               Q-1                                                                               1 H H  H  F  H H  -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                              Q-1                                                                               1 H H  H  Cl H H  -- OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                              Q-1                                                                               1 H H  H  Cl H H  -- CH.sub.3                                                                          CH.sub.3                                                                           N                                               Q-1                                                                               1 H H  Cl H  H H  -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                              Q-1                                                                               1 H H  Cl H  H H  -- CH.sub.3                                                                          OCH.sub.3                                                                          N                                               Q-1                                                                               1 H H  H  Br H H  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                              Q-1                                                                               1 H H  Br H  H H  -- CH.sub.3                                                                          OCH.sub.3                                                                          CH                                              Q-1                                                                               1 H H  Br H  H H  -- OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                              Q-1                                                                               1 H H  H  I  H H  -- CH.sub.3                                                                          CH.sub.3                                                                           N                                               Q-1                                                                               1 H H  I  H  H H  -- CH.sub.3                                                                          OCH.sub.3                                                                          N                                               Q-1                                                                               1 H H  H  CN H H  -- OCH.sub.3                                                                         OCH.sub.3                                                                          N                                               Q-1                                                                               1 H H  CN H  H H  -- OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                              Q-1                                                                               1 H H  H  CH.sub.3                                                                          H H  -- CH.sub.3                                                                          CH.sub.3                                                                           CH                                              __________________________________________________________________________

                  TABLE ID                                                         ______________________________________                                         General Structure I (wherein R.sub.12 is OH; R.sub.13 is CH.sub.3)                                                              m.p.                          Q    n     R     R.sub.1                                                                            R.sub.7                                                                            R.sub.8                                                                               X     Y     Z    (°C.)                  ______________________________________                                         Q-4  1     H     H   H   H      CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   H      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   H      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   H      CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-4  1     H     H   H   H      CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   H      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   H      Cl    OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   Cl     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   Cl     OCH.sub.3                                                                            CH.sub.3                                                                             N                                  Q-4  1     H     H   H   Cl     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   Cl     Cl    OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   F      CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-4  1     H     H   H   F      CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   F      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   F      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   F      CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   F      Cl    OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CN     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CN     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   OCH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   OCH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   OCH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     Cl    OCH.sub.3                                                                            CH                                 ______________________________________                                    

                  TABLE IE                                                         ______________________________________                                         General Structure I (wherein R.sub.12 is OH; R.sub.13 is CH.sub.3)                                                              m.p.                          Q    n     R     R.sub.1                                                                            R.sub.7                                                                            R.sub.8                                                                               X     Y     Z    (°C.)                  ______________________________________                                         Q-4  1     H     H   H   H      CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   H      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   H      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   H      CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-4  1     H     H   H   H      CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   H      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   H      Cl    OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   Cl     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   Cl     OCH.sub.3                                                                            CH.sub.3                                                                             N                                  Q-4  1     H     H   H   Cl     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   Cl     Cl    OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   F      CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-4  1     H     H   H   F      CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   F      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   F      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   F      CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   F      Cl    OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CN     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CN     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   OCH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   OCH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   OCH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     Cl    OCH.sub.3                                                                            CH                                 ______________________________________                                    

                  TABLE IF                                                         ______________________________________                                         General Structure I (wherein R.sub.12 is OCH.sub.3 ; R.sub.13 is H)                                                             m.p.                          Q    n     R     R.sub.1                                                                            R.sub.7                                                                            R.sub.8                                                                               X     Y     Z    (°C.)                  ______________________________________                                         Q-4  1     H     H   H   H      CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   H      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   H      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   H      CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-4  1     H     H   H   H      CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   H      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   H      Cl    OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   Cl     CH.sub.3                                                                             OCH.sub. 3                                                                           CH                                 Q-4  1     H     H   H   Cl     OCH.sub.3                                                                            CH.sub.3                                                                             N                                  Q-4  1     H     H   H   Cl     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   Cl     Cl    OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   F      CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-4  1     H     H   H   F      CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   F      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   F      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   F      CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   F      Cl    OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CN     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CN     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   OCH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   OCH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   OCH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     Cl    OCH.sub.3                                                                            CH                                 ______________________________________                                    

                  TABLE IG                                                         ______________________________________                                         General Structure I (wherein R.sub.12 is OCH.sub.3 ; R.sub.13 is               CH.sub.3)                                                                                                                       m.p.                          Q    n     R     R.sub.1                                                                            R.sub.7                                                                            R.sub.8                                                                               X     Y     Z    (°C.)                  ______________________________________                                         Q-4  1     H     H   H   H      CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   H      CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   H      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   H      CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-4  1     H     H   H   H      CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   H      OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   H      Cl    OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   Cl     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   Cl     OCH.sub.3                                                                            CH.sub.3                                                                             N                                  Q-4  1     H     H   H   Cl     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   Cl     Cl    OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   F      CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-4  1     H     H   H   F      CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   F      OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   F      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   F      CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   F      Cl    OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CN     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CN     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   OCH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   OCH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   OCH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                             N                                  Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                 Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                             CH                                 Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                            N                                  Q-4  1     H     H   H   CO.sub.2 CH.sub.3                                                                     Cl    OCH.sub.3                                                                            CH                                 ______________________________________                                    

                                      TABLE II                                     __________________________________________________________________________     General Structure II (wherein R.sub.12 and R.sub.13 are                        __________________________________________________________________________     H)                                                                                                                                   m.p.                     L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.2                                                                             R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                             R.sub.10                                                                              R.sub.11                                                                          X   Y   Z  (°C.)             __________________________________________________________________________     L-2                                                                               Q-1                                                                               0 H  H   --   H  H    H    H      -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-2                                                                               Q-1                                                                               0 H  H   --   H  Cl   H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-1                                                                               0 H  H   --   Cl Cl   H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-1                                                                               0 H  H   --   F  F    H    H      -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-2                                                                               Q-1                                                                               0 H  H   --   H  Br   H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-1                                                                               0 H  H   --   CH.sub.3                                                                          H    H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-2                                                                               Q-1                                                                               0 H  H   --   H  OCH.sub.3                                                                           H    H      -- Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-1                                                                               0 H  H   --   H  F    H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-1                                                                               0 H  H   --   Cl Br   H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-1                                                                               0 H  H   --   Cl CH.sub.3                                                                            H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-1                                                                               0 H  H   --   F  CH.sub.3                                                                            H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-1                                                                               0 H  H   --   H  Cl   Cl   H      -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-2                                                                               Q-1                                                                               0 H  H   --   H  CH.sub.3                                                                            F    F      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-1                                                                               0 H  CH.sub.3                                                                           --   H  H    H    H      -- Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-1                                                                               0 CH.sub.3                                                                          H   --   H  H    H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-1                                                                               1 H  H   --   F  F    H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-1                                                                               1 H  H   --   H  H    H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-2                                                                               0 H  H   --   H  H    --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-2                                                                               Q-2                                                                               0 H  H   --   H  H    --   --     H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-2                                                                               Q-2                                                                               0 H  H   --   H  H    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-2                                                                               0 H  H   --   Cl H    --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-2                                                                               0 H  H   --   F  H    --   --     H  Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-2                                                                               0 H  H   --   H  Br   --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-2                                                                               0 H  H   --   F  F    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-2                                                                               Q-2                                                                               0 H  H   --   Cl Cl   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-2                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-2                                                                               0 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-2                                                                               0 H  H   --   H  CO.sub.2 CH.sub.3                                                                   --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-2                                                                               Q-2                                                                               0 H  H   --   H  F    --   --     CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-2                                                                               0 H  OCH.sub.3                                                                          --   H  Cl   --   --     H  OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-2                                                                               Q-2                                                                               0 CH.sub.3                                                                          Cl  --   F  CH.sub.3                                                                            --   --     CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                          CH                          __________________________________________________________________________                                                           m.p.                     L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.3                                                                             R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                             R.sub.10                                                                              R.sub.11                                                                          X   Y   Z  (°C.)             __________________________________________________________________________     L-2                                                                               Q-2                                                                               1 H  H   --   H  Cl   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-2                                                                               1 H  H   --   Cl Cl   --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-2                                                                               Q-2                                                                               1 H  H   --   F  CH.sub.3                                                                            --   --     H  Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-3                                                                               0 H  H   CH.sub. 3                                                                           Cl Cl   --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            F  F    --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           N                           L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  Br   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          H    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  OCH.sub.3                                                                           --   --     H  Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  F    --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            Cl Br   --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            Cl CH.sub.3                                                                            --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           N                           L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-3                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                            H  H    --   --     H  Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-3                                                                               0 CH.sub.3                                                                          H   CH.sub.3                                                                            H  H    --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            F  F    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            H  H    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-4                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-2                                                                               Q-4                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-2                                                                               Q-4                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-4                                                                               0 H  H   --   Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-4                                                                               0 H  H   --   F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-4                                                                               0 H  H   --   H  Br   --   --     -- OCH.sub. 3                                                                         OCH.sub.3                                                                          CH                          L-2                                                                               Q-4                                                                               0 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-2                                                                               Q-4                                                                               0 H  H   --   Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-4                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-4                                                                               0 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-4                                                                               0 H  H   --   H  CO.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-2                                                                               Q-4                                                                               0 H  H   --   H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-4                                                                               0 H  OCH.sub.3                                                                          --   H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           __________________________________________________________________________                                                           m.p.                     L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.2                                                                             R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                             R.sub.10                                                                              R.sub.11                                                                          X   Y   Z  (° C.)            __________________________________________________________________________     L-2                                                                               Q-4                                                                               0 CH.sub.3                                                                          Cl  --   F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-4                                                                               1 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-4                                                                               1 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-2                                                                               Q-4                                                                               1 H  H   --   F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-5                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-2                                                                               Q-5                                                                               0 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-5                                                                               0 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-5                                                                               0 H  H   --   F  F    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-2                                                                               Q-5                                                                               0 H  H   --   H  Br   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-5                                                                               0 H  H   --   CH.sub.3                                                                          H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-2                                                                               Q-5                                                                               0 H  H   --   H  OCH.sub.3                                                                           --   --     -- Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-5                                                                               0 H  H   --   H  F    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-5                                                                               0 H  H   --   Cl Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-5                                                                               0 H  H   --   Cl CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-5                                                                               0 H  H   --   F  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-5                                                                               0 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-2                                                                               Q-5                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-5                                                                               0 H  CH.sub.3                                                                           --   H  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-5                                                                               0 CH.sub.3                                                                          H   --   H  H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-5                                                                               1 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-5                                                                               1 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-6                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-2                                                                               Q-6                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-2                                                                               Q-6                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-6                                                                               0 H  H   --   Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-6                                                                               0 H  H   --   F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-6                                                                               0 H  H   --   H  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-6                                                                               0 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-2                                                                               Q-6                                                                               0 H  H   --   Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-6                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-6                                                                               0 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-6                                                                               0 H  H   --   H  CO.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-2                                                                               Q-6                                                                               0 H  H   --   H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-6                                                                               0 H  OCH.sub.3                                                                          --   H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-2                                                                               Q-6                                                                               0 CH.sub.3                                                                          Cl  --   F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-6                                                                               1 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-6                                                                               1 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-2                                                                               Q-6                                                                               1 H  H   --   F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-7                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-2                                                                               Q-7                                                                               0 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-7                                                                               0 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-7                                                                               0 H  H   --   F  F    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-2                                                                               Q-7                                                                               0 H  H   --   H  Br   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-7                                                                               0 H  H   --   CH.sub.3                                                                          H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-2                                                                               Q-7                                                                               0 H  H   --   H  OCH.sub.3                                                                           --   --     -- Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-7                                                                               0 H  H   --   H  F    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-7                                                                               0 H  H   --   Cl Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-7                                                                               0 H  H   --   Cl CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-7                                                                               0 H  H   --   F  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-7                                                                               0 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-2                                                                               Q-7                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-7                                                                               0 H  CH.sub.3                                                                           --   H  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-7                                                                               0 CH.sub.3                                                                          H   --   H  H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-7                                                                               1 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-7                                                                               1 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-8                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-2                                                                               Q-8                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-2                                                                               Q-8                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-8                                                                               0 H  H   --   Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-8                                                                               0 H  H   --   F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-8                                                                               0 H  H   --   H  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-8                                                                               0 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-2                                                                               Q-8                                                                               0 H  H   --   Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-8                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-8                                                                               0 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          __________________________________________________________________________                                                           m.p.                     L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.3                                                                             R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                             R.sub.10                                                                              R.sub.11                                                                          X   Y   Z  (°C.)             __________________________________________________________________________     L-2                                                                               Q-8                                                                               0 H  H   --   H  CO.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-2                                                                               Q-8                                                                               0 H  H   --   H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-8                                                                               0 H  OCH.sub.3                                                                          --   H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-2                                                                               Q-8                                                                               0 CH.sub.3                                                                          Cl  --   F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-8                                                                               1 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-8                                                                               1 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-2                                                                               Q-8                                                                               1 H  H   --   F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-2                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            F  F    --   --     -- CH.sub.3                                                                           CH.sub. 3                                                                          N                           L-2                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  Br   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-2                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  OCH.sub.3                                                                           --   --     -- Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  F    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            Cl Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            Cl CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-2                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-9                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                            H  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-9                                                                               0 CH.sub.3                                                                          H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-9                                                                               1 H  H   CH.sub.3                                                                            F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-9                                                                               1 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-2                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-2                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-2                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-2                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-2                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          __________________________________________________________________________                                                           m.p.                     L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.2 /R.sub.3                                                                    R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                             R.sub.10                                                                              R.sub.11                                                                          X   Y   Z  (°C.)             __________________________________________________________________________     L-2                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  CO.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-2                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-2                                                                               Q-10                                                                              0 H  OCH.sub.3                                                                          CH.sub.3                                                                            H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-2                                                                               Q-10                                                                              0 CH.sub.3                                                                          Cl  CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-2                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-2                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                            H  H    H    H      -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                            H  Cl   H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                            Cl Cl   H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                            F  F    H    H      -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                            H  Br   H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          H    H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                            H  OCH.sub.3                                                                           H    H      -- Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                            H  F    H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                            Cl Br   H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                            Cl CH.sub.3                                                                            H    H      -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                            H  Cl   Cl   H      -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            F    F      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-1                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                            H  H    H    H      -- Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-1                                                                               0 CH.sub.3                                                                          H   CH.sub.3                                                                            H  H    H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-3                                                                               Q-1                                                                               1 H  H   CH.sub.3                                                                            F  F    H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-1                                                                               1 H  H   CH.sub.3                                                                            H  H    H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                            Cl H    --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                            F  H    --   --     H  Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                            H  Br   --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          __________________________________________________________________________                                                           m.p.                     L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.2                                                                             R.sub.7                                                                           R.sub.8                                                                             R.sub.3                                                                             R.sub.10                                                                              R.sub.11                                                                          X   Y   Z  (°C.)             __________________________________________________________________________     L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                            F  F    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                            Cl Cl   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          CH.sub.3                                                                            --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                            H  CO.sub.2 CH.sub.3                                                                   --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                            H  F    --   --     CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-2                                                                               0 H  OCH.sub.3                                                                          CH.sub.3                                                                            H  Cl   --   --     H  OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-3                                                                               Q-2                                                                               0 CH.sub.3                                                                          Cl  CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-2                                                                               1 H  H   CH.sub.3                                                                            H  Cl   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-2                                                                               1 H  H   CH.sub.3                                                                            Cl Cl   --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-3                                                                               Q-2                                                                               1 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     H  Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  H    CH.sub.3                                                                            --     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  H    CH.sub.3                                                                            --     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  Cl   CH.sub.3                                                                            --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            Cl Cl   CH.sub.3                                                                            --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            F  F    CH.sub.3                                                                            --     H  CH.sub.3                                                                           CH.sub.3                                                                           N                           L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  Br   CH.sub.3                                                                            --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          H    CH.sub.3                                                                            --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  OCH.sub.3                                                                           CH.sub.3                                                                            --     H  Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  F    CH.sub.3                                                                            --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            Cl Br   CH.sub.3                                                                            --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            Cl CH.sub.3                                                                            CH.sub.3                                                                            --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            CH.sub.3                                                                            --     CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  Cl   CH.sub.2 CH.sub.3                                                                   --     H  CH.sub.3                                                                           CH.sub.3                                                                           N                           L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            CH.sub.3                                                                            --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-3                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                            H  H    CH.sub.3                                                                            --     H  Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-3                                                                               0 CH.sub.3                                                                          H   CH.sub.3                                                                            H  H    CH.sub.3                                                                            --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-3                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            F  F    CH.sub.3                                                                            --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            H  H    CH.sub.3                                                                            --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                            Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           __________________________________________________________________________                                                           m.p.                     L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.2                                                                             R.sub.7                                                                           R.sub.8                                                                             R.sub. 9                                                                            R.sub.10                                                                              R.sub.11                                                                          X   Y   Z  (°C.)             __________________________________________________________________________     L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                            F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                            H  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                            F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                            H  CO.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                            H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-4                                                                               0 H  OCH.sub.3                                                                          CH.sub.3                                                                            H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-3                                                                               Q-4                                                                               0 CH.sub.3                                                                          Cl  CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-4                                                                               1 H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-4                                                                               1 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-3                                                                               Q-4                                                                               1 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                            F  F    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                            H  Br   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                            H  OCH.sub.3                                                                           --   --     -- Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                            H  F    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                            Cl Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                            Cl CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-5                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                            H  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-5                                                                               0 CH.sub.3                                                                          H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-3                                                                               Q-5                                                                               1 H  H   CH.sub.3                                                                            F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-5                                                                               1 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-6                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-3                                                                               Q-6                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-3                                                                               Q-6                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-6                                                                               0 H  H   CH.sub.3                                                                            Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-3                                                                               Q-6                                                                               0 H  H   CH.sub.3                                                                            F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-6                                                                               0 H  H   CH.sub.3                                                                            H  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-6                                                                               0 H  H   CH.sub.3                                                                            F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-3                                                                               Q-6                                                                               0 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-6                                                                               0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-6                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-6                                                                               0 H  H   CH.sub.3                                                                            H  CO.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-3                                                                               Q-6                                                                               0 H  H   CH.sub.3                                                                            H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-6                                                                               0 H  OCH.sub.3                                                                          CH.sub.3                                                                            H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-3                                                                               Q-6                                                                               0 CH.sub.3                                                                          Cl  CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-6                                                                               1 H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-6                                                                               1 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-3                                                                               Q-6                                                                               1 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-7                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-3                                                                               Q-7                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-7                                                                               0 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-7                                                                               0 H  H   CH.sub.3                                                                            F  F    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-3                                                                               Q-7                                                                               0 H  H   CH.sub.3                                                                            H  Br   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-3                                                                               Q-7                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-3                                                                               Q-7                                                                               0 H  H   CH.sub.3                                                                            H  OCH.sub.3                                                                           --   --     -- Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-7                                                                               0 H  H   CH.sub.3                                                                            H  F    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-7                                                                               0 H  H   CH.sub.3                                                                            Cl Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-7                                                                               0 H  H   CH.sub.3                                                                            Cl CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-3                                                                               Q-7                                                                               0 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-7                                                                               0 H  H   CH.sub. 3                                                                           H  Cl   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-3                                                                               Q-7                                                                               0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-7                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                            H  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-7                                                                               0 CH.sub.3                                                                          H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-3                                                                               Q-7                                                                               1 H  H   CH.sub.3                                                                            F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-7                                                                               1 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          __________________________________________________________________________                                                           m.p.                     L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.2                                                                             R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                             R.sub.3                                                                               R.sub.11                                                                          X   Y   Z  (°C.)             __________________________________________________________________________     L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                            Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                            F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                            H  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                            F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                            H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-8                                                                               0 H  OCH.sub.3                                                                          CH.sub.3                                                                            H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-3                                                                               Q-8                                                                               0 CH.sub.3                                                                          Cl  CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-8                                                                               1 H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-8                                                                               1 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-3                                                                               Q-8                                                                               1 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  H    --   CH.sub.3                                                                              -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   CH.sub.3                                                                              -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            Cl Cl   --   CH.sub.3                                                                              -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            F  F    --   CH.sub.3                                                                              -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  Br   --   CH.sub.3                                                                              -- CH.sub.3                                                                           OCH.sub.                                                                           N                           L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          H    --   CH.sub.3                                                                              -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  OCH.sub.3                                                                           --   CH.sub.3                                                                              -- Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  F    --   CH.sub.3                                                                              -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            Cl Br   --   CH.sub.3                                                                              -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            Cl CH.sub.3                                                                            --   CH.sub.3                                                                              -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   CH.sub.3                                                                              -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   CH.sub.3                                                                              -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   CH.sub.2 CH.sub.3                                                                     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-9                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                            H  H    --   CH.sub.2 CH.sub.3                                                                     -- Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-9                                                                               0 CH.sub.3                                                                          H   CH.sub.3                                                                            H  H    --   CH.sub.2 CH.sub.2 CH.sub.3                                                            -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-3                                                                               Q-9                                                                               1 H  H   CH.sub.3                                                                            F  F    --   CH.sub.3                                                                              -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-9                                                                               1 H  H   CH.sub.3                                                                            H  H    --   CH.sub.2 CH.sub.3                                                                     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  H    --   CH.sub.3                                                                              -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  H    --   CH.sub.3                                                                              -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  H    --   CH.sub.3                                                                              -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            Cl H    --   CH.sub.3                                                                              -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            F  H    --   CH.sub.3                                                                              -- Cl  OCH.sub.3                                                                          CH                          L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  Br   --   CH.sub.3                                                                              -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            F  F    --   CH.sub.3                                                                              -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            Cl Cl   --   CH.sub.3                                                                              -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   CH.sub.3                                                                              -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          CH.sub.3                                                                            --   CH.sub.3                                                                              -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  CO.sub.2 CH.sub.3                                                                   --   CH.sub.3                                                                              -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  F    --   CH.sub.3                                                                              -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-3                                                                               Q-10                                                                              0 H  OCH.sub.3                                                                          CH.sub.3                                                                            H  Cl   --   CH.sub.3                                                                              -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-3                                                                               Q-10                                                                              0 CH.sub.3                                                                          Cl  CH.sub.3                                                                            F  CH.sub.3                                                                            --   CH.sub.3                                                                              -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            H  Cl   --   CH.sub.2 CH.sub.3                                                                     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-3                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            Cl Cl   --   CH.sub.3                                                                              -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-3                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   CH.sub.2 CH.sub.3                                                                     -- Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-1                                                                               0 H  H   --   H  H    H    --     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-4                                                                               Q-1                                                                               0 H  H   --   Cl Cl   H    --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-1                                                                               0 H  H   --   F  F    H    --     H  CH.sub.3                                                                           CH.sub.3                                                                           N                           L-4                                                                               Q-1                                                                               0 H  H   --   H  Br   H    --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-1                                                                               0 H  H   --   CH.sub.3                                                                          Br   H    --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-4                                                                               Q-1                                                                               0 H  H   --   H  OCH.sub.3                                                                           H    --     H  Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-1                                                                               0 H  H   --   H  F    H    --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-1                                                                               0 H  H   --   Cl Br   H    --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-1                                                                               0 H  H   --   Cl CH.sub.3                                                                            H    --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-1                                                                               0 H  H   --   F  CH.sub.3                                                                            H    --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-1                                                                               0 H  H   --   H  Cl   Cl   --     H  CH.sub.3                                                                           CH.sub.3                                                                           N                           L-4                                                                               Q-1                                                                               0 H  H   --   H  CH.sub.3                                                                            F    --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-1                                                                               0 H  H   --   H  H    H    --     H  Cl  OCH.sub.3                                                                          CH                          __________________________________________________________________________                                                           m.p.                     L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.3                                                                             R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                             R.sub.10                                                                              R.sub.11                                                                          X   Y   Z  (°C.)             __________________________________________________________________________     L-4                                                                               Q-1                                                                               0 CH.sub.3                                                                          H   --   H  H    H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-1                                                                               1 H  H   --   F  F    H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-1                                                                               1 H  H   --   H  H    H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-2                                                                               0 H  H   --   H  H    --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-4                                                                               Q-2                                                                               0 H  H   --   H  H    --   --     H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-4                                                                               Q-2                                                                               0 H  H   --   H  H    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-2                                                                               0 H  H   --   Cl H    --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-2                                                                               0 H  H   --   F  H    --   --     H  Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-2                                                                               0 H  H   --   H  Br   --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-2                                                                               0 H  H   --   F  F    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-4                                                                               Q-2                                                                               0 H  H   --   Cl Cl   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-2                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-2                                                                               0 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-2                                                                               0 H  H   --   H  CO.sub.2 CH.sub.3                                                                   --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-4                                                                               Q-2                                                                               0 H  H   --   H  F    --   --     CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-2                                                                               0 H  OCH.sub.3                                                                          --   H  Cl   --   --     H  OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-4                                                                               Q-2                                                                               0 CH.sub.3                                                                          Cl  --   F  CH.sub.3                                                                            --   --     CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-2                                                                               1 H  H   --   H  Cl   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-2                                                                               1 H  H   --   Cl Cl   --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-4                                                                               Q-2                                                                               1 H  H   --   F  CH.sub.3                                                                            --   --     H  Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-4                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            Cl Cl   --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            F  F    --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           N                           L-4                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  Br   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          H    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-4                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  OCH.sub.3                                                                           --   --     H  Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  F    --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            Cl Br   --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            Cl CH.sub.3                                                                            --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            Cl Cl   --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           N                           L-4                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-3                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                            H  H    --   --     H  Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-3                                                                               0 CH.sub.3                                                                          H   CH.sub.3                                                                            H  H    --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            F  F    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            H  H    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-4                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-4                                                                               Q-4                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-4                                                                               Q-4                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-4                                                                               0 H  H   --   Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-4                                                                               0 H  H   --   F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-4                                                                               0 H  H   --   F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-4                                                                               0 H  H   --   H  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-4                                                                               0 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-4                                                                               Q-4                                                                               0 H  H   --   Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-4                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-4                                                                               0 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-4                                                                               0 H  H   --   H  CO.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-4                                                                               Q-4                                                                               0 H  H   --   H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-4                                                                               0 H  OCH.sub.3                                                                          --   H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-4                                                                               Q-4                                                                               0 CH.sub.3                                                                          Cl  --   F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-4                                                                               1 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-4                                                                               1 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-4                                                                               Q-4                                                                               1 H  H   --   F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-5                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-4                                                                               Q-5                                                                               0 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-5                                                                               0 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-5                                                                               0 H  H   --   F  F    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-4                                                                               Q-5                                                                               0 H  H   --   H  Br   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-5                                                                               0 H  H   --   CH.sub.3                                                                          H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-4                                                                               Q-5                                                                               0 H  H   --   H  OCH.sub.3                                                                           --   --     -- Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-5                                                                               0 H  H   --   H  F    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-5                                                                               0 H  H   --   Cl Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-5                                                                               0 H  H   --   Cl CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-5                                                                               0 H  H   --   F  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-5                                                                               0 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-4                                                                               Q-5                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-5                                                                               0 H  CH.sub.3                                                                           --   H  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-5                                                                               0 CH.sub.3                                                                          H   --   H  H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-5                                                                               1 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-5                                                                               1 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-6                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-4                                                                               Q-6                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-4                                                                               Q-6                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-6                                                                               0 H  H   --   Cl H    --   --     -- CH.sub. 3                                                                          OCH.sub.3                                                                          N                           L-4                                                                               Q-6                                                                               0 H  H   --   F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-6                                                                               0 H  H   --   H  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-6                                                                               0 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-4                                                                               Q-6                                                                               0 H  H   --   Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-6                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-6                                                                               0 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-6                                                                               0 H  H   --   H  CH.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-4                                                                               Q-6                                                                               0 H  H   --   H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-6                                                                               0 H  OCH.sub.3                                                                          --   H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-4                                                                               Q-6                                                                               0 CH.sub.3                                                                          Cl  --   F  CH.sub. 3                                                                           --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-6                                                                               1 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-6                                                                               1 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-4                                                                               Q-6                                                                               1 H  H   --   F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-7                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-4                                                                               Q-7                                                                               0 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-7                                                                               0 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-7                                                                               0 H  H   --   F  F    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-4                                                                               Q-7                                                                               0 H  H   --   H  Br   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-7                                                                               0 H  H   --   CH.sub.3                                                                          H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-4                                                                               Q-7                                                                               0 H  H   --   H  OCH.sub.3                                                                           --   --     -- Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-7                                                                               0 H  H   --   H  F    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-7                                                                               0 H  H   --   Cl Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-7                                                                               0 H  H   --   Cl CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-7                                                                               0 H  H   --   F  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-7                                                                               0 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-4                                                                               Q-7                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-7                                                                               0 H  CH.sub.3                                                                           --   H  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-7                                                                               0 CH.sub.3                                                                          H   --   H  H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-7                                                                               1 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-7                                                                               1 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-8                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-4                                                                               Q-8                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-4                                                                               Q-8                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-8                                                                               0 H  H   --   Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-8                                                                               0 H  H   --   F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-8                                                                               0 H  H   --   H  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-8                                                                               0 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-4                                                                               Q-8                                                                               0 H  H   --   Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-8                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-8                                                                               0 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-8                                                                               0 H  H   --   H  CH.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-4                                                                               Q-8                                                                               0 H  H   --   H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-8                                                                               0 H  OCH.sub.3                                                                          --   H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-4                                                                               Q-8                                                                               0 CH.sub.3                                                                          Cl  --   F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-8                                                                               1 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-8                                                                               1 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-4                                                                               Q-8                                                                               1 H  H   --   F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-4                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            F  F    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-4                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  Br   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-4                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  OCH.sub.3                                                                           --   --     -- Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  F    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            Cl Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            Cl CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-9                                                                               O H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-4                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-9                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                            H  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-9                                                                               0 CH.sub.3                                                                          H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-9                                                                               1 H  H   CH.sub.3                                                                            F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-9                                                                               1 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-4                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-4                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-4                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-4                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-4                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-4                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  CO.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-4                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-4                                                                               Q-10                                                                              0 H  OCH.sub.3                                                                          CH.sub.3                                                                            H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-4                                                                               Q-10                                                                              0 CH.sub. 3                                                                         Cl  CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-4                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-4                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-1                                                                               0 H  H   --   H  H    H    H      -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-5                                                                               Q-1                                                                               0 H  H   --   H  Cl   H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-1                                                                               0 H  H   --   Cl Cl   H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-1                                                                               0 H  H   --   F  F    H    H      -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-5                                                                               Q-1                                                                               0 H  H   --   H  Br   H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-1                                                                               0 H  H   --   CH.sub.3                                                                          H    H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-5                                                                               Q-1                                                                               0 H  H   --   H  OCH.sub.3                                                                           H    H      -- Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-1                                                                               0 H  H   --   H  F    H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-1                                                                               0 H  H   --   Cl Br   H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-1                                                                               0 H  H   --   Cl CH.sub.3                                                                            H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-1                                                                               0 H  H   --   F  CH.sub.3                                                                            H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-1                                                                               0 H  H   --   H  Cl   Cl   H      -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-5                                                                               Q-1                                                                               0 H  H   --   H  CH.sub.3                                                                            F    F      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-1                                                                               0 H  CH.sub.3                                                                           --   H  H    H    H      -- Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-1                                                                               0 CH.sub.3                                                                          H   --   H  H    H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-1                                                                               1 H  H   --   F  F    H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-1                                                                               1 H  H   --   H  H    H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-2                                                                               0 H  H   --   H  H    --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-5                                                                               Q-2                                                                               0 H  H   --   H  H    --   --     H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-5                                                                               Q-2                                                                               0 H  H   --   H  H    --   --     H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-5                                                                               Q-2                                                                               0 H  H   --   Cl H    --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-2                                                                               0 H  H   --   F  H    --   --     H  Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-2                                                                               0 H  H   --   H  Br   --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-2                                                                               0 H  H   --   F  F    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-5                                                                               Q-2                                                                               0 H  H   --   Cl Cl   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-2                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-2                                                                               0 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-2                                                                               0 H  H   --   H  CO.sub.2 CH.sub.3                                                                   --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-5                                                                               Q-2                                                                               0 H  H   --   H  F    --   --     CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-2                                                                               0 H  OCH.sub.3                                                                          --   H  Cl   --   --     H  OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-5                                                                               Q-2                                                                               0 CH.sub.3                                                                          Cl  --   F  CH.sub.3                                                                            --   --     CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-2                                                                               1 H  H   --   H  Cl   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-2                                                                               1 H  H   --   Cl Cl   --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-5                                                                               Q-2                                                                               1 H  H   --   F  CH.sub.3                                                                            --   --     H  Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-5                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            Cl Cl   --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            F  F    --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           N                           L-5                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  Br   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          H    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-5                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  OCH.sub.3                                                                           --   --     H  Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  F    --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            Cl Br   --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            Cl CH.sub.3                                                                            --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           N                           L-5                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-3                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                            H  H    --   --     H  Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-3                                                                               0 CH.sub.3                                                                          H   CH.sub.3                                                                            H  H    --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            F  F    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            H  H    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-4                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-5                                                                               Q-4                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-5                                                                               Q-4                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-4                                                                               0 H  H   --   Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-4                                                                               0 H  H   --   F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-4                                                                               0 H  H   --   H  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-4                                                                               0 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-5                                                                               Q-4                                                                               0 H  H   --   Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-4                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-4                                                                               0 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-4                                                                               0 H  H   --   H  CO.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-5                                                                               Q-4                                                                               0 H  H   --   H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-4                                                                               0 H  OCH.sub.3                                                                          --   H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-5                                                                               Q-4                                                                               0 CH.sub.3                                                                          Cl  --   F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-4                                                                               1 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-4                                                                               1 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-5                                                                               Q-4                                                                               1 H  H   --   F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-5                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-5                                                                               Q-5                                                                               0 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-5                                                                               0 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-5                                                                               0 H  H   --   F  F    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-5                                                                               Q-5                                                                               0 H  H   --   H  Br   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-5                                                                               0 H  H   --   CH.sub.3                                                                          H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-5                                                                               Q-5                                                                               0 H  H   --   H  OCH.sub.3                                                                           --   --     -- Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-5                                                                               0 H  H   --   Cl Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-5                                                                               0 H  H   --   Cl CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-5                                                                               0 H  H   --   F  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-5                                                                               0 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-5                                                                               Q-5                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-5                                                                               0 H  CH.sub.3                                                                           --   H  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-5                                                                               0 CH.sub.3                                                                          H   --   H  H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-5                                                                               1 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-5                                                                               1 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-6                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-5                                                                               Q-6                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-5                                                                               Q-6                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-6                                                                               0 H  H   --   Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-6                                                                               0 H  H   --   F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-6                                                                               0 H  H   --   H  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-6                                                                               0 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-5                                                                               Q-6                                                                               0 H  H   --   Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-6                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-6                                                                               0 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-6                                                                               0 H  H   --   H  CO.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-5                                                                               Q-6                                                                               0 H  H   --   H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-6                                                                               0 H  OCH.sub.3                                                                          --   H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-5                                                                               Q-6                                                                               0 CH.sub.3                                                                          Cl  --   F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-6                                                                               1 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-6                                                                               1 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-5                                                                               Q-6                                                                               1 H  H   --   F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-7                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-5                                                                               Q-7                                                                               0 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-7                                                                               0 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-7                                                                               0 H  H   --   F  F    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-5                                                                               Q-7                                                                               0 H  H   --   H  Br   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-7                                                                               0 H  H   --   CH.sub.3                                                                          H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-5                                                                               Q-7                                                                               0 H  H   --   H  OCH.sub.3                                                                           --   --     -- Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-7                                                                               0 H  H   --   H  F    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-7                                                                               0 H  H   --   Cl Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-7                                                                               0 H  H   --   Cl CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-7                                                                               0 H  H   --   F  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-7                                                                               0 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-5                                                                               Q-7                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-7                                                                               0 H  CH.sub.3                                                                           --   H  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-7                                                                               0 CH.sub.3                                                                          H   --   H  H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-7                                                                               1 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-7                                                                               1 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-8                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-5                                                                               Q-8                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-5                                                                               Q-8                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-8                                                                               0 H  H   --   Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-8                                                                               0 H  H   --   F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-8                                                                               0 H  H   --   H  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-8                                                                               0 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-5                                                                               Q-8                                                                               0 H  H   --   Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-8                                                                               9 H  H   --   H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-8                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-8                                                                               0 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-8                                                                               0 H  H   --   H  CO.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-5                                                                               Q-8                                                                               0 H  H   --   H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-8                                                                               0 H  OCH.sub.3                                                                          --   H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-5                                                                               Q-8                                                                               0 H  OCH.sub.3                                                                          --   H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-5                                                                               Q-8                                                                               0 CH.sub.3                                                                          Cl  --   F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-8                                                                               1 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-8                                                                               1 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-5                                                                               Q-8                                                                               1 H  H   --   F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-5                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            F  F    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-5                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  Br   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-5                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  OCH.sub.3                                                                           --   --     -- Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            Cl Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            Cl CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-5                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-9                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                            H  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-9                                                                               0 CH.sub.3                                                                          H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-9                                                                               1 H  H   CH.sub.3                                                                            F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-9                                                                               1 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-5                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-5                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-5                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-5                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-5                                                                               Q-10                                                                              0 H  H   CH.sub.2 CH.sub.3                                                                   Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  CO.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-5                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-5                                                                               Q-10                                                                              0 H  OCH.sub.3                                                                          CH.sub.3                                                                            H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-5                                                                               Q-10                                                                              0 CH.sub.3                                                                          Cl  CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-5                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-5                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-1                                                                               0 H  H   --   H  H    H    H      -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-6                                                                               Q-1                                                                               0 H  H   --   H  Cl   H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-1                                                                               0 H  H   --   Cl Cl   H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-1                                                                               0 H  H   --   F  F    H    H      -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-6                                                                               Q-1                                                                               0 H  H   --   H  Br   H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-1                                                                               0 H  H   --   CH.sub.3                                                                          H    H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-6                                                                               Q-1                                                                               0 H  H   --   H  OCH.sub.3                                                                           H    H      -- Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-1                                                                               0 H  H   --   H  F    H    H      -- Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-1                                                                               0 H  H   --   Cl Br   H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-1                                                                               0 H  H   --   Cl CH.sub.3                                                                            H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-1                                                                               0 H  H   --   F  CH.sub.3                                                                            H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-1                                                                               0 H  H   --   H  Cl   Cl   H      -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-6                                                                               Q-1                                                                               0 H  H   --   H  CH.sub.3                                                                            F    F      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-1                                                                               0 H  CH.sub.3                                                                           --   H  H    H    H      -- Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-1                                                                               0 CH.sub.3                                                                          H   --   H  H    H    H      -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-1                                                                               1 H  H   --   F  F    H    H      -- OCH.sub.3                                                                          OCH.sub.                                                                           CH                          L-6                                                                               Q-1                                                                               1 H  H   --   H  H    H    H      -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-2                                                                               0 H  H   --   H  H    --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-6                                                                               Q-2                                                                               9 H  H   --   H  H    --   --     H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-6                                                                               Q-2                                                                               0 H  H   --   H  H    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-2                                                                               0 H  H   --   Cl H    --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-2                                                                               0 H  H   --   F  H    --   --     H  Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-2                                                                               0 H  H   --   H  Br   --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-2                                                                               0 H  H   --   F  F    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-6                                                                               Q-2                                                                               0 H  H   --   Cl Cl   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-2                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-2                                                                               0 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-2                                                                               0 H  H   --   H  CO.sub.2 CH.sub.3                                                                   --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-6                                                                               Q-2                                                                               0 H  H   --   H  F    --   --     CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-2                                                                               0 H  OCH.sub.3                                                                          --   H  Cl   --   --     H  OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-6                                                                               Q-2                                                                               0 CH.sub.3                                                                          Cl  --   F  CH.sub.3                                                                            --   --     CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-2                                                                               1 H  H   --   H  Cl   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-2                                                                               1 H  H   --   Cl Cl   --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-6                                                                               Q-2                                                                               1 H  H   --   F  CH.sub.3                                                                            --   --     H  Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-6                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            Cl Cl   --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            F  F    --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           N                           L-6                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  Br   --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          H    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-6                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  OCH.sub.3                                                                           --   --     H  Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  F    --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            Cl Br   --   --     CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            Cl CH.sub.3                                                                            --   --     CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   --     H  CH.sub.3                                                                           CH.sub.3                                                                           N                           L-6                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-3                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                            H  H    --   --     H  Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-3                                                                               0 CH.sub.3                                                                          H   CH.sub.3                                                                            H  H    --   --     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            F  F    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            H  H    --   --     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-4                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-6                                                                               Q-4                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-6                                                                               Q-4                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-4                                                                               0 H  H   --   Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-4                                                                               0 H  H   --   F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-4                                                                               0 H  H   --   H  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.                                                                           CH                          L-6                                                                               Q-4                                                                               0 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-6                                                                               Q-4                                                                               0 H  H   --   Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-4                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-4                                                                               0 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-4                                                                               0 H  H   --   H  CO.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-6                                                                               Q-4                                                                               0 H  H   --   H  F    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-4                                                                               0 H  OCH.sub.3                                                                          --   H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-6                                                                               Q-4                                                                               0 CH.sub.3                                                                          Cl  --   F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-4                                                                               1 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-4                                                                               1 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-6                                                                               Q-4                                                                               1 H  H   --   F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-5                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-6                                                                               Q-5                                                                               0 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-5                                                                               0 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-5                                                                               0 H  H   --   F  F    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-6                                                                               Q-5                                                                               0 H  H   --   H  Br   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-5                                                                               0 H  H   --   CH.sub.3                                                                          H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-6                                                                               Q-5                                                                               0 H  H   --   H  OCH.sub.3                                                                           --   --     -- Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-5                                                                               0 H  H   --   H  F    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-5                                                                               0 H  H   --   Cl Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-5                                                                               0 H  H   --   Cl CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-5                                                                               0 H  H   --   F  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-5                                                                               0 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-6                                                                               Q-5                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-5                                                                               0 H  CH.sub.3                                                                           --   H  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-5                                                                               0 CH.sub.3                                                                          H   --   H  H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-5                                                                               1 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-5                                                                               1 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-6                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-6                                                                               Q-6                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-6                                                                               Q-6                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-6                                                                               0 H  H   --   Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-6                                                                               0 H  H   --   F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-6                                                                               0 H  H   --   H  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-6                                                                               0 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-6                                                                               Q-6                                                                               0 H  H   --   Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-6                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-6                                                                               0 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-6                                                                               0 H  H   --   H  CO.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-6                                                                               Q-6                                                                               0 H  H   --   H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-6                                                                               0 H  OCH.sub.3                                                                          --   H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-6                                                                               Q-6                                                                               0 CH.sub.3                                                                          Cl  --   F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-6                                                                               1 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-6                                                                               1 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-6                                                                               Q-6                                                                               1 H  H   --   F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-7                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-6                                                                               Q-7                                                                               0 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-7                                                                               0 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-7                                                                               0 H  H   --   F  F    --   --     -- CH.sub. 3                                                                          CH.sub.3                                                                           N                           L-6                                                                               Q-7                                                                               0 H  H   --   H  Br   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-7                                                                               0 H  H   --   CH.sub.3                                                                          H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-6                                                                               Q-7                                                                               0 H  H   --   H  OCH.sub.3                                                                           --   --     -- Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-7                                                                               0 H  H   --   H  F    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-7                                                                               0 H  H   --   Cl Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-7                                                                               0 H  H   --   Cl CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-7                                                                               0 H  H   --   F  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-7                                                                               0 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-6                                                                               Q-7                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-7                                                                               0 H  CH.sub.3                                                                           --   H  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-7                                                                               0 CH.sub.3                                                                          H   --   H  H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-7                                                                               1 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-7                                                                               1 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-8                                                                               0 H  H   --   H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-6                                                                               Q-8                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                          L-6                                                                               Q-8                                                                               0 H  H   --   H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-8                                                                               0 H  H   --   Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-8                                                                               0 H  H   --   F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-8                                                                               0 H  H   --   H  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-8                                                                               0 H  H   --   F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-6                                                                               Q-8                                                                               0 H  H   --   Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-8                                                                               0 H  H   --   H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-8                                                                               0 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-8                                                                               0 H  H   --   H  CO.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-6                                                                               Q-8                                                                               0 H  H   --   H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-8                                                                               0 H  OCH.sub.3                                                                          --   H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-6                                                                               Q-8                                                                               0 CH.sub.3                                                                          Cl  --   F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-8                                                                               1 H  H   --   H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-8                                                                               1 H  H   --   Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-6                                                                               Q-8                                                                               1 H  H   --   F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-6                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            F  F    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-6                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  Br   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-6                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  OCH.sub.3                                                                           --   --     -- Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  F    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-9                                                                               0 H  H   CH.sub.2 CH.sub.3                                                                   Cl Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-9                                                                               0 H  H   CH.sub.2 CH.sub.3                                                                   Cl CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           N                           L-6                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-9                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                            H  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-9                                                                               0 CH.sub.3                                                                          OCH.sub.3                                                                          CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-9                                                                               1 H  H   CH.sub.3                                                                            F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-9                                                                               1 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  H    --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-6                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  H    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            Cl H    --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                           L-6                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            F  H    --   --     -- Cl  OCH.sub.3                                                                          CH                          L-6                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            F  Br   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            F  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-6                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  CO.sub.2 CH.sub.3                                                                   --   --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                          L-6                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                            H  F    --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                          L-6                                                                               Q-10                                                                              0 H  OCH.sub.3                                                                          CH.sub.3                                                                            H  Cl   --   --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                           L-6                                                                               Q-10                                                                              0 CH Cl  CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-10                                                                              0 CH.sub.3                                                                          F   Cl   CH.sub.3                                                                          CH.sub.3                                                                            --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            H  Cl   --   --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                          L-6                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            Cl Cl   --   --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                           L-6                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --   --     -- Cl  OCH.sub.3                                                                          CH                          __________________________________________________________________________

                                      TABLE IIA                                    __________________________________________________________________________     General Structure II (wherein R.sub.12 is OH and R.sub.13 is H)                                                            m.p.                               L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.2                                                                          R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                          R.sub.10                                                                          R.sub.11                                                                          X   Y   Z  (°C.)                       __________________________________________________________________________     L-2                                                                               Q-1                                                                               1 H  H   --                                                                               H  H    H H  -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                    L-2                                                                               Q-1                                                                               1 H  H   --                                                                               H  Cl   H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 H  H   --                                                                               Cl Cl   H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 H  H   --                                                                               F  F    H H  -- CH.sub.3                                                                           CH.sub.3                                                                           N                                     L-2                                                                               Q-1                                                                               1 H  H   --                                                                               H  Br   H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                     L-2                                                                               Q-1                                                                               l H  H   --                                                                               CH.sub.3                                                                          H    H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                     L-2                                                                               Q-1                                                                               1 H  H   --                                                                               H  OCH.sub.3                                                                           H H  -- Cl  OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 H  H   --                                                                               H  F    H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 H  H   --                                                                               Cl Br   H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 H  H   --                                                                               Cl CH.sub.3                                                                            H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                     L-2                                                                               Q-1                                                                               1 H  H   --                                                                               F  CH.sub.3                                                                            H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 H  H   --                                                                               H  Cl   Cl                                                                               H  -- CH.sub.3                                                                           CH.sub.3                                                                           N                                     L-2                                                                               Q-1                                                                               1 H  H   --                                                                               H  CH.sub.3                                                                            F F  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 H  CH.sub.3                                                                           --                                                                               H  H    H H  -- Cl  OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 CH.sub.3                                                                          H   --                                                                               H  H    H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                     L-2                                                                               Q-1                                                                               1 H  H   --                                                                               F  F    H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 H  H   --                                                                               H  H    H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               H  H    --                                                                               -- H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               H  H    --                                                                               -- H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               H  H    --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               Cl H    --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                     L-2                                                                               Q-2                                                                               1 H  H   --                                                                               F  H    --                                                                               -- H  Cl  OCH.sub.3                                                                          CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               H  Br   --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               F  F    --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                     L-2                                                                               Q-2                                                                               1 H  H   --                                                                               Cl Cl   --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               H  CH.sub.3                                                                            --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               CH.sub.3                                                                          CH.sub.3                                                                            --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               H  CO.sub.2 CH.sub.3                                                                   --                                                                               -- H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               H  F    --                                                                               -- CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-2                                                                               1 H  OCH.sub.3                                                                          --                                                                               H  Cl   --                                                                               -- H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                     L-2                                                                               Q-2                                                                               1 CH.sub.3                                                                          Cl  --                                                                               F  CH.sub.3                                                                            --                                                                               -- CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                          CH                                    __________________________________________________________________________

                                      TABLE IIB                                    __________________________________________________________________________     General Structure II (wherein R.sub.12 is OCH.sub.3 and R.sub.13 is H)                                                     m.p.                               L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.2                                                                          R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                          R.sub.10                                                                          R.sub.11                                                                          X   Y   Z  (°C.)                       __________________________________________________________________________     L-2                                                                               Q-1                                                                               1 H  H   --                                                                               H  H    H H  -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                    L-2                                                                               Q-1                                                                               1 H  H   --                                                                               H  Cl   H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 H  H   --                                                                               Cl Cl   H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 H  H   --                                                                               F  F    H H  -- CH.sub.3                                                                           CH.sub.3                                                                           N                                     L-2                                                                               Q-1                                                                               1 H  H   --                                                                               H  Br   H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                     L-2                                                                               Q-1                                                                               1 H  H   --                                                                               CH.sub.3                                                                          H    H H  -- OCH.sub.3                                                                          OCH.sub. 3                                                                         N                                     L-2                                                                               Q-1                                                                               1 H  H   --                                                                               H  OCH.sub.3                                                                           H H  -- Cl  OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 H  H   --                                                                               H  F    H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 H  H   --                                                                               Cl Br   H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 H  H   --                                                                               Cl CH.sub.3                                                                            H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                     L-2                                                                               Q-1                                                                               1 H  H   --                                                                               F  CH.sub.3                                                                            H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 H  H   --                                                                               H  Cl   Cl                                                                               H  -- CH.sub.3                                                                           CH.sub.3                                                                           N                                     L-2                                                                               Q-1                                                                               1 H  H   --                                                                               H  CH.sub.3                                                                            F F  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 H  CH.sub.3                                                                           --                                                                               H  H    H H  -- Cl  OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 CH.sub.3                                                                          H   --                                                                               H  H    H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                     L-2                                                                               Q-1                                                                               1 H  H   --                                                                               F  F    H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-1                                                                               1 H  H   --                                                                               H  H    H H  -- OCH.sub. 3                                                                         OCH.sub.3                                                                          CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               H  H    --                                                                               -- H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               H  H    --                                                                               -- H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               H  H    --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               Cl H    --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                     L-2                                                                               Q-2                                                                               1 H  H   --                                                                               F  H    --                                                                               -- H  Cl  OCH.sub.3                                                                          CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               H  Br   --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               F  F    --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                     L-2                                                                               Q-2                                                                               1 H  H   --                                                                               Cl Cl   --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               H  CH.sub.3                                                                            --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               CH.sub.3                                                                          CH.sub.3                                                                            --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               H  CO.sub.2 CH.sub.3                                                                   --                                                                               -- H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                    L-2                                                                               Q-2                                                                               1 H  H   --                                                                               H  F    --                                                                               -- CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                    L-2                                                                               Q-2                                                                               1 H  OCH.sub.3                                                                          --                                                                               H  Cl   --                                                                               -- H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                     L-2                                                                               Q-2                                                                               1 CH.sub.3                                                                          Cl  --                                                                               F  CH.sub.3                                                                            --                                                                               -- CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                          CH                                    __________________________________________________________________________

                                      TABLE IIC                                    __________________________________________________________________________     General Structure II (wherein R.sub.12 is OH and R.sub.13 is                   __________________________________________________________________________     H)                                                                                                                            m.p.                            L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.2                                                                             R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                          R.sub.10                                                                          R.sub.11                                                                          X   Y   Z  (°C.)                    __________________________________________________________________________     L-2                                                                               Q-4                                                                               1 H  H   --   H  H    --                                                                               -- -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   H  Cl   --                                                                               -- -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   Cl Cl   --                                                                               -- -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   F  F    --                                                                               -- -- CH.sub.3                                                                           CH.sub.3                                                                           N                                  L-2                                                                               Q-4                                                                               1 H  H   --   H  Br   --                                                                               -- -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-2                                                                               Q-4                                                                               1 H  H   --   CH.sub.3                                                                          H    --                                                                               -- -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-2                                                                               Q-4                                                                               1 H  H   --   H  OCH.sub.3                                                                           --                                                                               -- -- Cl  OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   H  F    --                                                                               -- -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   Cl Br   --                                                                               -- -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   Cl CH.sub.3                                                                            --                                                                               -- -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-2                                                                               Q-4                                                                               1 H  H   --   F  CH.sub.3                                                                            --                                                                               -- -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   H  Cl   --                                                                               -- -- CH.sub.3                                                                           CH.sub.3                                                                           N                                  L-2                                                                               Q-4                                                                               1 H  H   --   H  CH.sub.3                                                                            --                                                                               -- -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  CH.sub.3                                                                           --   H  H    --                                                                               -- -- Cl  OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 CH.sub.3                                                                          H   --   H  H    --                                                                               -- -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-2                                                                               Q-4                                                                               1 H  H   --   F  F    --                                                                               -- -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   H  H    --                                                                               -- -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   H  H    --                                                                               -- H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   H  H    --                                                                               -- H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   H  H    --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   Cl H    --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-2                                                                               Q-4                                                                               1 H  H   --   F  H    --                                                                               -- H  Cl  OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   H  Br   --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   F  F    --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-2                                                                               Q-4                                                                               1 H  H   --   Cl Cl   --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   H  CH.sub.3                                                                            --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   H  CO.sub.2 CH.sub.3                                                                   --                                                                               -- H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-2                                                                               Q-4                                                                               1 H  H   --   H  F    --                                                                               -- CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  OCH.sub.3                                                                          --   H  Cl   --                                                                               -- H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                  L-2                                                                               Q-4                                                                               1 CH.sub.3                                                                          Cl  --   F  CH.sub.3                                                                            --                                                                               -- CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 __________________________________________________________________________                                                    m.p.                            L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.3                                                                             R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                          R.sub.10                                                                          R.sub.11                                                                          X   Y   Z  (°C.)                    __________________________________________________________________________     L-4                                                                               Q-1                                                                               1 CH.sub.3                                                                          H   --   H  H    H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-4                                                                               Q-1                                                                               1 H  H   --   F  F    H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-4                                                                               Q-1                                                                               1 H  H   --   H  H    H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-4                                                                               Q-2                                                                               1 H  H   --   H  H    --                                                                               -- H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-4                                                                               Q-2                                                                               1 H  H   --   H  H    --                                                                               -- H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                                 L-4                                                                               Q-2                                                                               1 H  H   --   H  H    --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-4                                                                               Q-2                                                                               1 H  H   --   Cl H    --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-4                                                                               Q-2                                                                               1 H  H   --   F  H    --                                                                               -- H  Cl  OCH.sub.3                                                                          CH                                 L-4                                                                               Q-2                                                                               1 H  H   --   H  Br   --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-4                                                                               Q-2                                                                               1 H  H   --   F  F    --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-4                                                                               Q-2                                                                               1 H  H   --   Cl Cl   --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-4                                                                               Q-2                                                                               1 H  H   --   H  CH.sub.3                                                                            --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-4                                                                               Q-2                                                                               1 H  H   --   CH.sub.3                                                                          CH.sub.3                                                                            --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-4                                                                               Q-2                                                                               1 H  H   --   H  CO.sub.2 CH.sub.3                                                                   --                                                                               -- H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-4                                                                               Q-2                                                                               1 H  H   --   H  F    --                                                                               -- CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-4                                                                               Q-2                                                                               1 H  OCH.sub.3                                                                          --   H  Cl   --                                                                               -- H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                  L-4                                                                               Q-2                                                                               1 CH.sub.3                                                                          Cl  --   F  CH.sub.3                                                                            --                                                                               -- CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-4                                                                               Q-2                                                                               1 H  H   --   H  Cl   --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-4                                                                               Q-2                                                                               1 H  H   --   Cl Cl   --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-4                                                                               Q-2                                                                               1 H  H   --   F  CH.sub.3                                                                            --                                                                               -- H  Cl  OCH.sub.3                                                                          CH                                 L-4                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            H  H    --                                                                               -- H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-4                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            H  Cl   --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-4                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            Cl Cl   --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-4                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            F  F    --                                                                               -- H  CH.sub.3                                                                           CH.sub.3                                                                           N                                  L-4                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            H  Br   --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-4                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            CH.sub.3                                                                          H    --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-4                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            H  OCH.sub.3                                                                           --                                                                               -- H  Cl  OCH.sub.3                                                                          CH                                 L-4                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            H  F    --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-4                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            Cl Br   --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-4                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            Cl CH.sub.3                                                                            --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-4                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-4                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                            Cl Cl   --                                                                               -- H  CH.sub.3                                                                           CH.sub.3                                                                           N                                  L-5                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            F  H    --                                                                               -- -- Cl  OCH.sub.3                                                                          CH                                 L-5                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            H  Br   --                                                                               -- -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-5                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            F  F    --                                                                               -- -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-5                                                                               Q-10                                                                              1 H  H   CH.sub.2 CH.sub.3                                                                   Cl Cl   --                                                                               -- -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-5                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            H  CH.sub.3                                                                            --                                                                               -- -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-5                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            CH.sub.3                                                                          CH.sub.3                                                                            --                                                                               -- -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-5                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            H  CO.sub.2 CH.sub.3                                                                   --                                                                               -- -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-5                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            H  F    --                                                                               -- -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-5                                                                               Q-10                                                                              1 H  OCH.sub.3                                                                          CH.sub.3                                                                            H  Cl   --                                                                               -- -- OCH.sub.3                                                                          CH.sub.3                                                                           N                                  L-5                                                                               Q-10                                                                              1 CH.sub.3                                                                          Cl  CH.sub.3                                                                            F  CH.sub.3                                                                            --                                                                               -- -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-5                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            H  Cl   --                                                                               -- -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-5                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            Cl Cl   --                                                                               -- -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-5                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                            F  CH.sub.3                                                                            --                                                                               -- -- Cl  OCH.sub.3                                                                          CH                                 L-6                                                                               Q-1                                                                               1 H  H   --   H  H    H H  -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-6                                                                               Q-1                                                                               1 H  H   --   H  Cl   H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-6                                                                               Q-1                                                                               1 H  H   --   Cl Cl   H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-6                                                                               Q-1                                                                               1 H  H   --   F  F    H H  -- CH.sub.3                                                                           CH.sub.3                                                                           N                                  L-6                                                                               Q-1                                                                               1 H  H   --   H  Br   H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-6                                                                               Q-1                                                                               1 H  H   --   CH.sub.3                                                                          H    H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-6                                                                               Q-1                                                                               1 H  H   --   H  OCH.sub.3                                                                           H H  -- Cl  OCH.sub.3                                                                          CH                                 L-6                                                                               Q-1                                                                               1 H  H   --   H  F    H H  -- CH.sub.3                                                                           Cl  CH                                 L-6                                                                               Q-1                                                                               1 H  H   --   Cl Br   H H  -- OCH.sub.3                                                                          OCH.sub. 3                                                                         CH                                 L-6                                                                               Q-1                                                                               1 H  H   --   Cl CH.sub.3                                                                            H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-6                                                                               Q-1                                                                               1 H  H   --   F  CH.sub.3                                                                            H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-6                                                                               Q-1                                                                               1 H  H   --   H  Cl   Cl                                                                               H  -- CH.sub.3                                                                           CH.sub.3                                                                           N                                  L-6                                                                               Q-1                                                                               1 H  H   --   H  CH.sub.3                                                                            F F  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-6                                                                               Q-1                                                                               1 H  CH.sub.3                                                                           --   H  H    H H  -- Cl  OCH.sub.3                                                                          CH                                 L-6                                                                               Q-1                                                                               1 CH.sub.3                                                                          H   --   H  H    H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-6                                                                               Q-1                                                                               1 H  H   --   F  F    H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-6                                                                               Q-1                                                                               1 H  H   --   H  H    H H  -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-6                                                                               Q-2                                                                               1 H  H   --   H  H    --                                                                               -- H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-6                                                                               Q-2                                                                               1 H  H   --   H  H    --                                                                               -- H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                                 __________________________________________________________________________

                                      TABLE IID                                    __________________________________________________________________________     General Structure IIa (where R.sub.12 and R.sub.13 are H)                      __________________________________________________________________________                                                      m.p.                          L  Q.sub.1                                                                           n  R  R.sub.1                                                                            R.sub.2                                                                           R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                           R.sub.10                                                                          R.sub.11                                                                           X   Y   Z   (°C.)                  __________________________________________________________________________     L-2                                                                               Q-1                                                                               0  H  H   -- H  H    H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                L-2                                                                               Q-1                                                                               0  H  H   -- H  Cl   H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-2                                                                               Q-1                                                                               0  H  H   -- Cl Cl   H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-1                                                                               0  H  H   -- F  F    H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           N                                 L-2                                                                               Q-1                                                                               0  H  H   -- H  Br   H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-2                                                                               Q-1                                                                               0  H  H   -- CH.sub.3                                                                          H    H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                 L-2                                                                               Q-1                                                                               0  H  H   -- H  OCH.sub.3                                                                           H  H  --  Cl  OCH.sub.3                                                                          CH                                L-2                                                                               Q-1                                                                               0  H  H   -- H  F    H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-2                                                                               Q-1                                                                               0  H  H   -- Cl Br   H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-1                                                                               0  H  H   -- Cl CH.sub.3                                                                            H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-2                                                                               Q-1                                                                               0  H  H   -- F  CH.sub.3                                                                            H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-1                                                                               0  H  H   -- H  Cl   Cl H  --  CH.sub.3                                                                           CH.sub.3                                                                           N                                 L-2                                                                               Q-1                                                                               0  H  H   -- H  CH.sub.3                                                                            F  F  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-1                                                                               0  H  CH.sub.3                                                                           -- H  H    H  H  --  Cl  OCH.sub.3                                                                          CH                                L-2                                                                               Q-1                                                                               0  CH.sub.3                                                                          H   -- H  H    H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-2                                                                               Q-1                                                                               1  H  H   -- F  F    H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-1                                                                               1  H  H   -- H  H    H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-2                                                                               0  H  H   -- H  H    -- -- H   CH.sub.3                                                                           CH.sub.3                                                                           CH                                L-2                                                                               Q-2                                                                               0  H  H   -- H  H    -- -- H   OCH.sub.3                                                                          CH.sub.3                                                                           CH                                L-2                                                                               Q-2                                                                               0  H  H   -- H  H    -- -- H   OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-2                                                                               0  H  H   -- Cl H    -- -- H   CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-2                                                                               Q-2                                                                               0  H  H   -- F  H    -- -- H   Cl  OCH.sub.3                                                                          CH                                L-2                                                                               Q-2                                                                               0  H  H   -- H  Br   -- -- H   OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-2                                                                               0  H  H   -- F  F    -- -- H   OCH.sub.3                                                                          OCH.sub.3                                                                          N                                 L-2                                                                               Q-2                                                                               0  H  H   -- Cl Cl   -- -- H   CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-2                                                                               Q-2                                                                               0  H  H   -- H  CH.sub.3                                                                            -- -- H   CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-2                                                                               Q-2                                                                               0  H  H   -- CH.sub.3                                                                          CH.sub.3                                                                            -- -- H   OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-2                                                                               0  H  H   -- H  CO.sub.2 CH.sub.3                                                                   -- -- H   CH.sub.3                                                                           CH.sub.3                                                                           CH                                L-2                                                                               Q-2                                                                               0  H  H   -- H  F    -- -- CH.sub.3                                                                           OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-2                                                                               0  H  OCH.sub.3                                                                          -- H  Cl   -- -- H   OCH.sub.3                                                                          CH.sub.3                                                                           N                                 L-2                                                                               Q-2                                                                               0  CH.sub.3                                                                          Cl  -- F  CH.sub.3                                                                            -- -- CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                                                                          CH                                __________________________________________________________________________                                                      m.p.                          L  Q.sub.1                                                                           n  R  R.sub.1                                                                            R.sub.3                                                                           R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                           R.sub.10                                                                          R.sub.11                                                                           X   Y   Z   (°C.)                  __________________________________________________________________________     L-2                                                                               Q-2                                                                               1  H  H   -- H  Cl   -- -- H   CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-2                                                                               Q-2                                                                               1  H  H   -- Cl Cl   -- -- H   OCH.sub.3                                                                          OCH.sub.3                                                                          N                                 L-2                                                                               Q-2                                                                               1  H  H   -- F  CH.sub.3                                                                            -- -- H   Cl  OCH.sub. 3                                                                         CH                                L-2                                                                               Q-3                                                                               0  H  H   CH.sub.3                                                                          H  H    -- -- H   CH.sub.3                                                                           CH.sub.3                                                                           CH                                L-2                                                                               Q-3                                                                               0  H  H   CH.sub.3                                                                          H  Cl   -- -- H   CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-2                                                                               Q-3                                                                               0  H  H   CH.sub.3                                                                          Cl Cl   -- -- H   OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-3                                                                               0  H  H   CH.sub.3                                                                          F  F    -- -- H   CH.sub.3                                                                           CH.sub.3                                                                           N                                 L-2                                                                               Q-3                                                                               0  H  H   CH.sub.3                                                                          H  Br   -- -- H   CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-2                                                                               Q-3                                                                               0  H  H   CH.sub.3                                                                          CH.sub.3                                                                          H    -- -- H   OCH.sub.3                                                                          OCH.sub.3                                                                          N                                 L-2                                                                               Q-3                                                                               0  H  H   CH.sub.3                                                                          H  OCH.sub.3                                                                           -- -- H   Cl  OCH.sub.3                                                                          CH                                L-2                                                                               Q-3                                                                               0  H  H   CH.sub.3                                                                          H  F    -- -- H   CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-2                                                                               Q-3                                                                               0  H  H   CH.sub.3                                                                          Cl Br   -- -- H   OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-3                                                                               0  H  H   CH.sub.3                                                                          Cl CH.sub.3                                                                            -- -- H   CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-2                                                                               Q-3                                                                               0  H  H   CH.sub. 3                                                                         F  CH.sub.3                                                                            -- -- CH.sub.3                                                                           OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-3                                                                               0  H  H   CH.sub.3                                                                          H  Cl   -- -- H   CH.sub.3                                                                           CH.sub.3                                                                           N                                 L-2                                                                               Q-3                                                                               0  H  H   CH.sub.3                                                                          H  CH.sub.3                                                                            -- -- H   OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-3                                                                               0  H  CH.sub.3                                                                           CH.sub.3                                                                          H  H    -- -- H   Cl  OCH.sub.3                                                                          CH                                L-2                                                                               Q-3                                                                               0  CH.sub.3                                                                          H   CH.sub.3                                                                          H  H    -- -- H   CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-2                                                                               Q-3                                                                               1  H  H   CH.sub.3                                                                          F  F    -- -- H   OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-3                                                                               1  H  H   CH.sub.3                                                                          H  H    -- -- H   OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-4                                                                               0  H  H   -- H  H    -- -- --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                L-2                                                                               Q-4                                                                               0  H  H   -- H  H    -- -- --  OCH.sub.3                                                                          CH.sub.3                                                                           CH                                L-2                                                                               Q-4                                                                               0  H  H   -- H  H    -- -- --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-4                                                                               0  H  H   -- Cl H    -- -- --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-2                                                                               Q-4                                                                               0  H  H   -- F  H    -- -- --  Cl  OCH.sub.3                                                                          CH                                L-2                                                                               Q-4                                                                               0  H  H   -- H  Br   -- -- --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-4                                                                               0  H  H   -- F  F    -- -- --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                 L-2                                                                               Q-4                                                                               0  H  H   -- Cl Cl   -- -- --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-2                                                                               Q-4                                                                               0  H  H   -- H  CH.sub.3                                                                            -- -- --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-2                                                                               Q-4                                                                               0  H  H   -- CH.sub.3                                                                          CH.sub.3                                                                            -- -- --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-4                                                                               0  H  H   -- H  CO.sub.2 CH.sub.3                                                                   -- -- --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                L-2                                                                               Q-4                                                                               0  H  H   -- H  F    -- -- --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-4                                                                               0  H  OCH.sub.3                                                                          -- H  Cl   -- -- --  OCH.sub.3                                                                          CH.sub.3                                                                           N                                 L-2                                                                               Q-8                                                                               0  H  H   -- H  CO.sub.2 CH.sub.3                                                                   -- -- --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                L-2                                                                               Q-8                                                                               0  H  H   -- H  F    -- -- --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-8                                                                               0  H  OCH.sub.3                                                                          -- H  Cl   -- -- --  OCH.sub.3                                                                          CH.sub.3                                                                           N                                 L-2                                                                               Q-8                                                                               0  CH.sub.3                                                                          Cl  -- F  CH.sub.3                                                                            -- -- --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-2                                                                               Q-8                                                                               1  H  H   -- H  Cl   -- -- --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-2                                                                               Q-8                                                                               1  H  H   -- Cl Cl   -- -- --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                 L-2                                                                               Q-8                                                                               1  H  H   -- F  CH.sub.3                                                                            -- -- --  Cl  OCH.sub.3                                                                          CH                                L-2                                                                               Q-9                                                                               0  H  H   CH.sub.3                                                                          H  H    -- -- --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                L-2                                                                               Q-9                                                                               0  H  H   CH.sub.3                                                                          H  Cl   -- -- --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-2                                                                               Q-9                                                                               0  H  H   CH.sub.3                                                                          Cl Cl   -- -- --  OCH.sub.3                                                                          OCH.sub. 3                                                                         CH                                L-2                                                                               Q-9                                                                               0  H  H   CH.sub.3                                                                          F  F    -- -- --  CH.sub.3                                                                           CH.sub.3                                                                           N                                 L-2                                                                               Q-9                                                                               0  H  H   CH.sub.3                                                                          H  Br   -- -- --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-2                                                                               Q-9                                                                               0  H  H   CH.sub.3                                                                          CH.sub.3                                                                          H    -- -- --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                 L-2                                                                               Q-9                                                                               0  H  H   CH.sub.3                                                                          H  OCH.sub.3                                                                           -- -- --  Cl  OCH.sub.3                                                                          CH                                L-2                                                                               Q-9                                                                               0  H  H   CH.sub.3                                                                          H  F    -- -- --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-2                                                                               Q-9                                                                               0  H  H   CH.sub.3                                                                          Cl Br   -- -- --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-9                                                                               0  H  H   CH.sub.3                                                                          Cl CH.sub.3                                                                            -- -- --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-2                                                                               Q-9                                                                               0  H  H   CH.sub.3                                                                          F  CH.sub.3                                                                            -- -- --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-9                                                                               0  H  H   CH.sub.3                                                                          H  Cl   -- -- --  CH.sub.3                                                                           CH.sub.3                                                                           N                                 L-2                                                                               Q-9                                                                               0  H  H   CH.sub.3                                                                          H  CH.sub.3                                                                            -- -- --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-9                                                                               0  H  CH.sub.3                                                                           CH.sub.3                                                                          H  H    -- -- --  Cl  OCH.sub.3                                                                          CH                                L-2                                                                               Q-9                                                                               0  CH.sub.3                                                                          H   CH.sub.3                                                                          H  H    -- -- --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-2                                                                               Q-9                                                                               1  H  H   CH.sub.3                                                                          F  F    -- -- --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-9                                                                               1  H  H   CH.sub.3                                                                          H  H    -- -- --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-10                                                                              0  H  H   CH.sub.3                                                                          H  H    -- -- --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                L-2                                                                               Q-10                                                                              0  H  H   CH.sub.3                                                                          H  H    -- -- --  OCH.sub.3                                                                          CH.sub.3                                                                           CH                                L-2                                                                               Q-10                                                                              0  H  H   CH.sub.3                                                                          H  H    -- -- --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-10                                                                              0  H  H   CH.sub.3                                                                          Cl H    -- -- --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-2                                                                               Q-10                                                                              0  H  H   CH.sub.3                                                                          F  H    -- -- --  Cl  OCH.sub.3                                                                          CH                                L-2                                                                               Q-10                                                                              0  H  H   CH.sub.3                                                                          H  Br   -- -- --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-2                                                                               Q-10                                                                              0  H  H   CH.sub.3                                                                          F  F    -- -- --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                 L-2                                                                               Q-10                                                                              0  H  H   CH.sub.3                                                                          Cl Cl   -- -- --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                __________________________________________________________________________                                                      m.p.                          L  Q.sub.1                                                                           n  R  R.sub.1                                                                            R.sub.2                                                                           R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                           R.sub.10                                                                          R.sub.11                                                                           X   Y   Z   (°C.)                  __________________________________________________________________________     L-3                                                                               Q-1                                                                               0  H  H   CH.sub.3                                                                          H  H    H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           CH                                L-3                                                                               Q-1                                                                               0  H  H   CH.sub.3                                                                          H  Cl   H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-3                                                                               Q-1                                                                               0  H  H   CH.sub.3                                                                          Cl Cl   H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-3                                                                               Q-1                                                                               0  H  H   CH.sub.3                                                                          F  F    H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           N                                 L-3                                                                               Q-1                                                                               0  H  H   CH.sub.3                                                                          H  Br   H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-3                                                                               Q-1                                                                               0  H  H   CH.sub.3                                                                          CH.sub.3                                                                          H    H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                 L-3                                                                               Q-1                                                                               0  H  H   CH.sub.3                                                                          H  OCH.sub.3                                                                           H  H  --  Cl  OCH.sub.3                                                                          CH                                L-3                                                                               Q-1                                                                               0  H  H   CH.sub.3                                                                          H  F    H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-3                                                                               Q-1                                                                               0  H  H   CH.sub.3                                                                          Cl Br   H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-3                                                                               Q-1                                                                               0  H  H   CH.sub.3                                                                          Cl CH.sub.3                                                                            H  H  --  CH.sub.3                                                                           CH.sub.3                                                                           N                                 L-3                                                                               Q-1                                                                               0  H  H   CH.sub.3                                                                          F  CH.sub.3                                                                            H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-3                                                                               Q-1                                                                               0  H  H   CH.sub.3                                                                          H  Cl   Cl H  --  CH.sub.3                                                                           CH.sub.3                                                                           N                                 L-3                                                                               Q-1                                                                               0  H  H   CH.sub.3                                                                          H  CH.sub.3                                                                            F  F  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-3                                                                               Q-1                                                                               0  H  CH.sub.3                                                                           CH.sub.3                                                                          H  H    H  H  --  Cl  OCH.sub.3                                                                          CH                                L-3                                                                               Q-1                                                                               0  CH.sub.3                                                                          H   CH.sub.3                                                                          H  H    H  H  --  CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-3                                                                               Q-1                                                                               1  H  H   CH.sub.3                                                                          F  F    H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-3                                                                               Q-1                                                                               1  H  H   CH.sub.3                                                                          H  H    H  H  --  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-3                                                                               Q-2                                                                               0  H  H   CH.sub.3                                                                          H  H    -- -- H   CH.sub.3                                                                           CH.sub.3                                                                           CH                                L-3                                                                               Q-2                                                                               0  H  H   CH.sub.3                                                                          H  H    -- -- H   OCH.sub.3                                                                          CH.sub.3                                                                           CH                                L-3                                                                               Q-2                                                                               0  H  H   CH.sub.3                                                                          H  H    -- -- H   OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-3                                                                               Q-2                                                                               0  H  H   CH.sub.3                                                                          Cl H    -- -- H   CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-3                                                                               Q-2                                                                               0  H  H   CH.sub.3                                                                          F  H    -- -- H   Cl  OCH.sub.3                                                                          CH                                L-3                                                                               Q-2                                                                               0  H  H   CH.sub.3                                                                          H  Br   -- -- H   OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                __________________________________________________________________________                                                      m.p.                          L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.2                                                                           R.sub.7                                                                           R.sub.8                                                                             R.sub.3                                                                             R.sub.10                                                                          R.sub.11                                                                          X   Y   Z   (°C.)                  __________________________________________________________________________     L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                          F  F    --   -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                 L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                          Cl Cl   --   -- H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                          H  CH.sub.3                                                                            --   -- H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                            --   -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                          H  CO.sub.2 CH.sub.3                                                                   --   -- H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                          H  F    --   -- CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-3                                                                               Q-2                                                                               0 H  OCH.sub.3                                                                          CH.sub.3                                                                          H  Cl   --   -- H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                 L-3                                                                               Q-2                                                                               0 CH.sub.3                                                                          Cl  CH.sub.3                                                                          F  CH.sub.3                                                                            --   -- CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-3                                                                               Q-2                                                                               1 H  H   CH.sub.3                                                                          H  Cl   --   -- H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-3                                                                               Q-2                                                                               1 H  H   CH.sub.3                                                                          Cl Cl   --   -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                 L-3                                                                               Q-2                                                                               1 H  H   CH.sub.3                                                                          F  CH.sub.3                                                                            --   -- H  Cl  OCH.sub.3                                                                          CH                                L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          H  H    CH.sub.3                                                                            -- H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          H  Cl   CH.sub.3                                                                            -- H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          Cl Cl   CH.sub.3                                                                            -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          F  F    CH.sub.3                                                                            -- H  CH.sub.3                                                                           CH.sub.3                                                                           N                                 L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          H  Br   CH.sub.3                                                                            -- H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          CH.sub.3                                                                          H    CH.sub.3                                                                            -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                 L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          H  OCH.sub.3                                                                           CH.sub.3                                                                            -- H  Cl  OCH.sub.3                                                                          CH                                L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          H  F    CH.sub.3                                                                            -- H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          Cl Br   CH.sub.3                                                                            -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          Cl CH.sub.3                                                                            CH.sub.3                                                                            -- H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          F  CH.sub.3                                                                            CH.sub.3                                                                            -- CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-3                                                                               Q-3                                                                               0 H  H   CH.sub. 3                                                                         H  Cl   CH.sub.2 CH.sub.3                                                                   -- H  CH.sub.3                                                                           CH.sub.3                                                                           N                                 L-3                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          H  CH.sub.3                                                                            CH.sub.3                                                                            -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-3                                                                               Q-3                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                          H  H    CH.sub.3                                                                            -- H  Cl  OCH.sub.3                                                                          CH                                L-3                                                                               Q-3                                                                               0 CH.sub.3                                                                          H   CH.sub.3                                                                          H  H    CH.sub.3                                                                            -- H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                 L-3                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                          F  F    CH.sub.3                                                                            -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-3                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                          H  H    CH.sub.3                                                                            -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                          H  H    --   -- -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                          H  H    --   -- -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                                L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                          H  H    --   -- -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                          Cl H    --   -- -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                 __________________________________________________________________________                                                       m.p.                         L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.2                                                                           R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                          R.sub.3                                                                               R.sub.11                                                                          X   Y   Z   (°C.)                 __________________________________________________________________________     L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                          H  H    --                                                                               --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                               L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                          H  H    --                                                                               --     -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                               L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                          H  H    --                                                                               --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                          Cl H    --                                                                               --     -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                          F  H    --                                                                               --     -- Cl  OCH.sub.3                                                                          CH                               L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                          H  Br   --                                                                               --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                          F  F    --                                                                               --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                          Cl Cl   --                                                                               --     -- CH.sub. 3                                                                          OCH.sub.3                                                                          CH                               L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                          H  CH.sub.3                                                                            --                                                                               --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                            --                                                                               --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                          CH.sub.3                                                                          CO.sub.2 CH.sub.3                                                                   --                                                                               --     -- CH.sub.3                                                                           CH.sub.3                                                                           CH                               L-3                                                                               Q-8                                                                               0 H  H   CH.sub.3                                                                          H  F    --                                                                               --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-3                                                                               Q-8                                                                               0 H  OCH.sub.3                                                                          CH.sub.3                                                                          H  Cl   --                                                                               --     -- OCH.sub.3                                                                          CH.sub.3                                                                           N                                L-3                                                                               Q-8                                                                               0 CH.sub.3                                                                          Cl  CH.sub.3                                                                          F  CH.sub.3                                                                            --                                                                               --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-3                                                                               Q-8                                                                               1 H  H   CH.sub.3                                                                          H  Cl   --                                                                               --     -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-3                                                                               Q-8                                                                               1 H  H   CH.sub.3                                                                          Cl Cl   --                                                                               --     -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                L-3                                                                               Q-8                                                                               1 H  H   CH.sub.3                                                                          F  CH.sub.3                                                                            --                                                                               --     -- Cl  OCH.sub.3                                                                          CH                               L-3                                                                               Q-9                                                                               0 H  H   CH.sub. 3                                                                         H  H    --                                                                               CH.sub.3                                                                              -- CH.sub.3                                                                           CH.sub.3                                                                           CH                               L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                          H  Cl   --                                                                               CH.sub.3                                                                              -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                          Cl Cl   --                                                                               CH.sub.3                                                                              -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                          F  F    --                                                                               CH.sub.3                                                                              -- CH.sub.3                                                                           CH.sub.3                                                                           N                                L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                          H  Br   --                                                                               CH.sub.3                                                                              -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                          CH.sub.3                                                                          H    --                                                                               CH.sub.3                                                                              -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                          H  OCH.sub.3                                                                           --                                                                               CH.sub.3                                                                              -- Cl  OCH.sub.3                                                                          CH                               L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                          H  F    --                                                                               CH.sub.3                                                                              -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                          Cl Br   --                                                                               CH.sub.3                                                                              -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                          Cl CH.sub.3                                                                            --                                                                               CH.sub.3                                                                              -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                          F  CH.sub.3                                                                            --                                                                               CH.sub.3                                                                              -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                          H  Cl   --                                                                               CH.sub.3                                                                              -- CH.sub.3                                                                           CH.sub.3                                                                           N                                L-3                                                                               Q-9                                                                               0 H  H   CH.sub.3                                                                          H  CH.sub.3                                                                            --                                                                               CH.sub.2 CH.sub.3                                                                     -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-3                                                                               Q-9                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                          H  H    --                                                                               CH.sub.2 CH.sub.3                                                                     -- Cl  OCH.sub.3                                                                          CH                               L-3                                                                               Q-9                                                                               0 CH.sub.3                                                                          H   CH.sub.3                                                                          H  H    --                                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                            -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                __________________________________________________________________________

                                      TABLE IIE                                    __________________________________________________________________________     General Structure IIb (wherein R.sub.12 and R.sub.13 are                       __________________________________________________________________________     H)                                                                             L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.2                                                                           R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                          R.sub.10                                                                            R.sub.11                                                                          X   Y   Z  m.p. (°C.)               __________________________________________________________________________     L-2                                                                               Q-1                                                                               0 H  H   -- H  H    H H    -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-2                                                                               Q-1                                                                               0 H  H   -- H  Cl   H H    -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-1                                                                               0 H  H   -- Cl Cl   H H    -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-1                                                                               0 H  H   -- F  F    H H    -- CH.sub.3                                                                           CH.sub.3                                                                           N                                  L-2                                                                               Q-1                                                                               0 H  H   -- H  Br   H H    -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-2                                                                               Q-1                                                                               0 H  H   -- CH.sub.3                                                                          H    H H    -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-2                                                                               Q-1                                                                               0 H  H   -- H  OCH.sub.3                                                                           H H    -- Cl  OCH.sub.3                                                                          CH                                 L-2                                                                               Q-1                                                                               0 H  H   -- H  F    H H    -- CH.sub. 3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-1                                                                               0 H  H   -- Cl Br   H H    -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-1                                                                               0 H  H   -- Cl CH.sub.3                                                                            H H    -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-2                                                                               Q-1                                                                               0 H  H   -- F  CH.sub.3                                                                            H H    -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-1                                                                               0 H  H   -- H  Cl   Cl                                                                               H    -- CH.sub.3                                                                           CH.sub.3                                                                           N                                  L-2                                                                               Q-1                                                                               0 H  H   -- H  CH.sub.3                                                                            F F    -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-1                                                                               0 H  CH.sub.3                                                                           -- H  H    H H    -- Cl  OCH.sub.3                                                                          CH                                 L-2                                                                               Q-1                                                                               0 CH.sub.3                                                                          H   -- H  H    H H    -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-2                                                                               Q-1                                                                               1 H  H   -- F  F    H H    -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-1                                                                               1 H  H   -- H  H    H H    -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-2                                                                               0 H  H   -- H  H    --                                                                               --   H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-2                                                                               Q-2                                                                               0 H  H   -- H  H    --                                                                               --   H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                                 L-2                                                                               Q-2                                                                               0 H  H   -- H  H    --                                                                               --   H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-2                                                                               0 H  H   -- Cl H    --                                                                               --   H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-2                                                                               Q-2                                                                               0 H  H   -- F  H    --                                                                               --   H  Cl  OCH.sub.3                                                                          CH                                 L-2                                                                               Q-2                                                                               0 H  H   -- H  Br   --                                                                               --   H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-2                                                                               0 H  H   -- F  F    --                                                                               --   H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-2                                                                               Q-2                                                                               0 H  H   -- Cl Cl   --                                                                               --   H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-2                                                                               0 H  H   -- H  CH.sub.3                                                                            --                                                                               --   H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-2                                                                               0 H  H   -- CH.sub.3                                                                          CH.sub.3                                                                            --                                                                               --   H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-2                                                                               0 H  H   -- H  CO.sub.2 CH.sub.3                                                                   --                                                                               --   H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-2                                                                               Q-2                                                                               0 H  H   -- H  F    --                                                                               --   CH.sub.3                                                                          OCH.sub. 3                                                                         OCH.sub.3                                                                          CH                                 L-2                                                                               Q-2                                                                               0 H  OCH.sub.3                                                                          -- H  Cl   --                                                                               --   H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                  L-2                                                                               Q-2                                                                               0 CH.sub.3                                                                          Cl  -- F  CH.sub.3                                                                            --                                                                               --   CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-1                                                                               0 H  H   -- H  OH   --                                                                               H    -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                 __________________________________________________________________________     L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.3                                                                           R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                          R.sub.10                                                                            R.sub.11                                                                          X   Y   Z  m.p. (°C.)               __________________________________________________________________________     L-2                                                                               Q-1                                                                               0 H  H   -- H  OH   --                                                                               H    -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-1                                                                               0 H  H   -- H  OH   --                                                                               H    -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-1                                                                               0 H  H   -- H  OH   --                                                                               H    -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-2                                                                               Q-1                                                                               0 H  H   -- H  OH   --                                                                               H    -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-2                                                                               Q-1                                                                               0 H  H   -- H  OH   --                                                                               H    -- Cl  OCH.sub.3                                                                          N                                  L-2                                                                               Q-2                                                                               1 H  H   -- H  Cl   --                                                                               --   H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-2                                                                               1 H  H   -- Cl Cl   --                                                                               --   H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-2                                                                               Q-2                                                                               1 H  H   -- F  CH.sub.3                                                                            --                                                                               --   H  Cl  OCH.sub.3                                                                          CH                                 L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          H  H    --                                                                               --   H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          H  Cl   --                                                                               --   H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          Cl Cl   --                                                                               --   H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          F  F    --                                                                               --   H  CH.sub.3                                                                           CH.sub.3                                                                           N                                  L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          H  Br   --                                                                               --   H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          CH.sub.3                                                                          H    --                                                                               --   H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          H  OCH.sub.3                                                                           --                                                                               --   H  Cl  OCH.sub.3                                                                          CH                                 L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          H  F    --                                                                               --   H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          Cl Br   --                                                                               --   H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          Cl CH.sub.3                                                                            --                                                                               --   H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          F  CH.sub.3                                                                            --                                                                               --   CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          H  Cl   --                                                                               --   H  CH.sub.3                                                                           CH.sub.3                                                                           N                                  L-2                                                                               Q-3                                                                               0 H  H   CH.sub.3                                                                          H  CH.sub.3                                                                            --                                                                               --   H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-3                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                          H  H    --                                                                               --   H  Cl  OCH.sub.3                                                                          CH                                 L-2                                                                               Q-3                                                                               0 CH.sub.3                                                                          H   CH.sub.3                                                                          H  H    --                                                                               --   H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-2                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                          F  F    --                                                                               --   H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-3                                                                               1 H  H   CH.sub.3                                                                          H  H    --                                                                               --   H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               0 H  H   -- H  H    --                                                                               --   -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-2                                                                               Q-4                                                                               0 H  H   -- H  H    --                                                                               --   -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                                 L-2                                                                               Q-4                                                                               0 H  H   -- H  H    --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               0 H  H   -- Cl H    --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-2                                                                               Q-4                                                                               0 H  H   -- F  H    --                                                                               --   -- Cl  OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               0 H  H   -- H  Br   --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               0 H  H   -- F  F    --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-2                                                                               Q-4                                                                               0 H  H   -- Cl Cl   --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 __________________________________________________________________________     L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.2                                                                           R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                          R.sub.10                                                                            R.sub.11                                                                          X   Y   Z  m.p. (°C.)               __________________________________________________________________________     L-2                                                                               Q-4                                                                               0 H  H   -- H  CH.sub.3                                                                            --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               0 H  H   -- CH.sub.3                                                                          CH.sub.3                                                                            --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               0 H  H   -- H  CO.sub.2 CH.sub.3                                                                   --                                                                               --   -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-2                                                                               Q-4                                                                               0 H  H   -- H  F    --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               0 H  OCH.sub.3                                                                          -- H  Cl   --                                                                               --   -- OCH.sub.3                                                                          CH.sub.3                                                                           N                                  L-2                                                                               Q-4                                                                               0 CH.sub.3                                                                          Cl  -- F  CH.sub.3                                                                            --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  H   -- H  Cl   --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-4                                                                               1 H  H   -- Cl Cl   --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-2                                                                               Q-4                                                                               1 H  H   -- F  CH.sub.3                                                                            --                                                                               --   -- Cl  OCH.sub.3                                                                          CH                                 L-2                                                                               Q-5                                                                               0 H  H   -- H  H    --                                                                               --   -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-2                                                                               Q-5                                                                               0 H  H   -- H  Cl   --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-5                                                                               0 H  H   -- Cl Cl   --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-5                                                                               0 H  H   -- F  F    --                                                                               --   -- CH.sub.3                                                                           CH.sub.3                                                                           N                                  L-2                                                                               Q-5                                                                               0 H  H   -- H  Br   --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-2                                                                               Q-5                                                                               0 H  H   -- CH.sub.3                                                                          H    --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-2                                                                               Q-5                                                                               0 H  H   -- H  OCH.sub.3                                                                           --                                                                               --   -- Cl  OCH.sub.3                                                                          CH                                 L-2                                                                               Q-5                                                                               0 H  H   -- H  F    --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-5                                                                               0 H  H   -- Cl Br   --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-5                                                                               0 H  H   -- Cl CH.sub.3                                                                            --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-2                                                                               Q-5                                                                               0 H  H   -- F  CH.sub.3                                                                            --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-5                                                                               0 H  H   -- H  Cl   --                                                                               --   -- CH.sub.3                                                                           CH.sub.3                                                                           N                                  L-2                                                                               Q-5                                                                               0 H  H   -- H  CH.sub.3                                                                            --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-5                                                                               0 H  CH.sub.3                                                                           -- H  H    --                                                                               --   -- Cl  OCH.sub.3                                                                          CH                                 L-2                                                                               Q-5                                                                               0 CH.sub.3                                                                          H   -- H  H    --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-2                                                                               Q-5                                                                               1 H  H   -- F  F    --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-5                                                                               1 H  H   -- H  H    --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-6                                                                               0 H  H   -- H  H    --                                                                               --   -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-2                                                                               Q-6                                                                               0 H  H   -- H  H    --                                                                               --   -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                                 L-2                                                                               Q-6                                                                               0 H  H   -- H  H    --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-6                                                                               0 H  H   -- Cl H    --                                                                               --   -- CH.sub.3                                                                           OCH.sub. 3                                                                         N                                  L-2                                                                               Q-6                                                                               0 H  H   -- F  H    --                                                                               --   -- Cl  OCH.sub.3                                                                          CH                                 L-2                                                                               Q-6                                                                               0 H  H   -- H  Br   --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-6                                                                               0 H  H   -- F  F    --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  __________________________________________________________________________     L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.2                                                                           R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                          R.sub.10                                                                            R.sub.11                                                                          X   Y   Z  m.p. (°C.)               __________________________________________________________________________     L-2                                                                               Q-6                                                                               0 H  H   -- Cl Cl   --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-6                                                                               0 H  H   -- H  CH.sub.3                                                                            --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-2                                                                               Q-6                                                                               0 H  H   -- CH.sub.3                                                                          CH.sub.3                                                                            --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-2                                                                               Q-6                                                                               0 H  H   -- H  CO.sub.2 CH.sub.3                                                                   --                                                                               --   -- Cl  CH.sub.3                                                                           CH                                 L-2                                                                               Q-6                                                                               0 H  H   -- H  F    --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                          H  H    H H    -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                          H  Cl   H H    -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                          Cl Cl   H H    -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                          F  F    H H    -- CH.sub.3                                                                           CH.sub.3                                                                           N                                  L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                          H  Br   H H    -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                          CH.sub.3                                                                          H    H H    -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                          H  OCH.sub.3                                                                           H H    -- Cl  OCH.sub.3                                                                          CH                                 L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                          H  F    H H    -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                          Cl Br   H H    -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                          Cl CH.sub.3                                                                            H H    -- CH.sub.3                                                                           CH.sub.3                                                                           N                                  L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                          F  CH.sub.3                                                                            H H    -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                          H  Cl   Cl                                                                               H    -- CH.sub.3                                                                           CH.sub.3                                                                           N                                  L-3                                                                               Q-1                                                                               0 H  H   CH.sub.3                                                                          H  CH.sub.3                                                                            F F    -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-1                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                          H  H    H H    -- Cl  OCH.sub.3                                                                          CH                                 L-3                                                                               Q-1                                                                               0 CH.sub.3                                                                          H   CH.sub.3                                                                          H  H    H H    -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-3                                                                               Q-1                                                                               1 H  H   CH.sub.3                                                                          F  F    H H    -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-1                                                                               1 H  H   CH.sub.3                                                                          H  H    H H    -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                          H  H    --                                                                               --   H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                          H  H    --                                                                               --   H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                                 L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                          H  H    --                                                                               --   H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                          Cl H    --                                                                               --   H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                          F  H    --                                                                               --   H  Cl  OCH.sub.3                                                                          CH                                 L-3                                                                               Q-2                                                                               0 H  H   CH.sub.3                                                                          H  Br   --                                                                               --   H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 __________________________________________________________________________     L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.2                                                                           R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                          R.sub.10                                                                            R.sub.11                                                                          X   Y   Z  m.p. (°C.)               __________________________________________________________________________     L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                          F  H    --                                                                               --   -- Cl  OCH.sub.3                                                                          CH                                 L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                          H  Br   --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                          F  F    --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                          Cl Cl   --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                          H  CH.sub.3                                                                            --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                            --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                          H  CO.sub.2 CH.sub.3                                                                   --                                                                               --   -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-3                                                                               Q-4                                                                               0 H  H   CH.sub.3                                                                          H  F    --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-4                                                                               0 H  OCH.sub.3                                                                          CH.sub.3                                                                          H  Cl   --                                                                               --   -- OCH.sub.3                                                                          CH.sub.3                                                                           N                                  L-3                                                                               Q-4                                                                               0 CH.sub.3                                                                          Cl  CH.sub.3                                                                          F  CH.sub.3                                                                            --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-3                                                                               Q-4                                                                               1 H  H   CH.sub.3                                                                          H  Cl   --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-3                                                                               Q-4                                                                               1 H  H   CH.sub.3                                                                          Cl Cl   --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-3                                                                               Q-4                                                                               1 H  H   CH.sub.3                                                                          F  CH.sub.3                                                                            --                                                                               --   -- Cl  OCH.sub.3                                                                          CH                                 L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                          H  H    --                                                                               --   -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                          H  Cl   --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                          Cl Cl   --                                                                               --   -- OCH.sub.3                                                                          OCH.sub. 3                                                                         CH                                 L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                          F  F    --                                                                               --   -- CH.sub.3                                                                           CH.sub.3                                                                           N                                  L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                          H  Br   --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                          CH.sub.3                                                                          H    --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                          H  OCH.sub.3                                                                           --                                                                               --   -- Cl  OCH.sub.3                                                                          CH                                 L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                          H  F    --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                          Cl Br   --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                          Cl CH.sub.3                                                                            --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                          F  CH.sub.3                                                                            --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                          H  Cl   --                                                                               --   -- CH.sub.3                                                                           CH.sub.3                                                                           N                                  L-3                                                                               Q-5                                                                               0 H  H   CH.sub.3                                                                          H  CH.sub.3                                                                            --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-5                                                                               0 H  CH.sub.3                                                                           CH.sub.3                                                                          H  H    --                                                                               --   -- Cl  OCH.sub.3                                                                          CH                                 L-3                                                                               Q-5                                                                               0 CH.sub.3                                                                          H   CH.sub.3                                                                          H  H    --                                                                               --   -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-3                                                                               Q-5                                                                               1 H  H   CH.sub.3                                                                          F  F    --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-5                                                                               1 H  H   CH.sub.3                                                                          H  H    --                                                                               --   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-6                                                                               0 H  H   CH.sub.3                                                                          H  H    --                                                                               --   -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-3                                                                               Q-6                                                                               0 H  H   CH.sub.3                                                                          H  H    --                                                                               --   -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                                 __________________________________________________________________________     L  Q.sub.1                                                                           n R  R.sub.1                                                                            R.sub.2                                                                           R.sub.7                                                                           R.sub.8                                                                             R.sub.9                                                                          R.sub.3                                                                             R.sub.10                                                                          X   Y   Z  m.p. (°C.)               __________________________________________________________________________     L-3                                                                               Q-9                                                                               1 H  H   CH.sub.3                                                                          F  F    --                                                                               CH.sub.3                                                                            -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-9                                                                               1 H  H   CH.sub.3                                                                          H  H    --                                                                               CH.sub.2 CH.sub.3                                                                   -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                          H  H    --                                                                               CH.sub.3                                                                            -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                          H  H    --                                                                               CH.sub.3                                                                            -- OCH.sub.3                                                                          CH.sub.3                                                                           CH                                 L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                          H  H    --                                                                               CH.sub.3                                                                            -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                          Cl H    --                                                                               CH.sub.3                                                                            -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                  L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                          F  H    --                                                                               CH.sub.3                                                                            -- Cl  OCH.sub.3                                                                          CH                                 L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                          H  Br   --                                                                               CH.sub.3                                                                            -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                          F  F    --                                                                               CH.sub.3                                                                            -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                          Cl Cl   --                                                                               CH.sub.3                                                                            -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                          H  CH.sub.3                                                                            --                                                                               CH.sub.3                                                                            -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                            --                                                                               CH.sub.3                                                                            -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                          H  CO.sub.2 CH.sub.3                                                                   --                                                                               CH.sub.3                                                                            -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                 L-3                                                                               Q-10                                                                              0 H  H   CH.sub.3                                                                          H  F    --                                                                               CH.sub.3                                                                            -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                 L-3                                                                               Q-10                                                                              0 H  OCH.sub.3                                                                          CH.sub.3                                                                          H  Cl   --                                                                               CH.sub.3                                                                            -- OCH.sub.3                                                                          CH.sub.3                                                                           N                                  L-3                                                                               Q-10                                                                              0 CH.sub.3                                                                          Cl  CH.sub.3                                                                          F  CH.sub.3                                                                            --                                                                               CH.sub.3                                                                            -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-3                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                          H  Cl   --                                                                               CH.sub.2 CH.sub.3                                                                   -- CH.sub.3                                                                           OCH.sub.3                                                                          CH                                 L-3                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                          Cl Cl   --                                                                               CH.sub.3                                                                            -- OCH.sub.3                                                                          OCH.sub.3                                                                          N                                  L-3                                                                               Q-10                                                                              1 H  H   CH.sub.3                                                                          F  CH.sub.3                                                                            --                                                                               CH.sub.2 CH.sub.3                                                                   -- Cl  OCH.sub.3                                                                          CH                                 __________________________________________________________________________

                                      TABLE III                                    __________________________________________________________________________     General Structure III (wherein R.sub.12 and R.sub.13 are                       __________________________________________________________________________     H)                                                                                                                                        m.p.                A  Q  n  R  R.sub.1                                                                           R.sub.3                                                                           R.sub.7                                                                           R.sub.8                                                                           R.sub.9                                                                           R.sub.10                                                                          R.sub.11                                                                          X.sub.1                                                                             Y.sub.1                                                                            Y.sub.2                                                                            X.sub.2                                                                            Y.sub.3                                                                             X.sub.3                                                                            (°C.)        __________________________________________________________________________     A-2                                                                               Q-1                                                                               0  H  H  -- H  H  H  H  -- CH.sub.3                                                                            O   --  --  --   --                      A-2                                                                               Q-1                                                                               0  H  H  -- H  H  H  H  -- CH.sub.                                                                             CH.sub.2                                                                           --  --  --   --                      A-2                                                                               Q-1                                                                               0  H  H  -- H  H  H  H  -- OCH.sub.3                                                                           O   --  --  --   --                      A-2                                                                               Q-5                                                                               0  H  H  -- H  H  -- -- -- CH.sub.3                                                                            CH.sub.2                                                                           --  --  --   --                      A-2                                                                               Q-2                                                                               0  H  H  -- H  Cl -- -- H  OCF.sub.2 H                                                                         O   --  --  --   --                      A-3                                                                               Q-1                                                                               0  H  H  -- H  H  H  H  -- CH.sub.3                                                                            --  --  --  --   --                      A-3                                                                               Q-1                                                                               0  H  H  -- H  H  H  H  -- OCH.sub.3                                                                           --  --  --  --   --                      A-3                                                                               Q-1                                                                               0  H  H  -- H  F  H  Cl -- OCF.sub.2 H                                                                         --  --  --  --   --                      A-3                                                                               Q-1                                                                               1  H  H  -- Cl Cl H  H  -- CH.sub.3                                                                            --  --  --  --   --                      A-3                                                                               Q-1                                                                               0  H  H  -- CH.sub.3                                                                          H  H  H  -- OCH.sub.3                                                                           --  --  --  --   --                      A-3                                                                               Q-4                                                                               0  H  H  -- H  H  -- -- -- OCH.sub.3                                                                           --  --  --  --   --                      A-3                                                                               Q-3                                                                               0  H  H  CH.sub.3                                                                          H  CH.sub.3                                                                          -- -- H  CH.sub.3                                                                            --  --  --  --   --                      A-4                                                                               Q-1                                                                               0  H  H  -- H  H  H  H  -- CH.sub.3                                                                            --  H   --  --   --                      A-4                                                                               Q-1                                                                               0  H  H  -- H  Cl H  H  -- OCH.sub.3                                                                           --  H   --  --   --  --                  A-4                                                                               Q-1                                                                               1  H  H  -- F  F  Cl CH.sub.3                                                                          -- CH.sub.3                                                                            --  CH.sub.3                                                                           --  --   --                      A-4                                                                               Q-6                                                                               0  H  H  -- H  H  -- -- -- OCH.sub.3                                                                           --  H   --  --   --                      A-4                                                                               Q-7                                                                               0  H  H  -- CH.sub.3                                                                          F  -- -- -- CH.sub.3                                                                            --  CH.sub.3                                                                           --  --   --                      A-5                                                                               Q-1                                                                               0  H  H  -- H  H  H  H  -- --   --  --  CH.sub.3                                                                           CH.sub.3                                                                            --                      A-5                                                                               Q-1                                                                               0  H  H  -- Cl H  H  Cl -- --   --  --  OCH.sub.3                                                                          CH.sub.3                                                                            --                      A-5                                                                               Q-10                                                                              0  H  H  CH.sub.3                                                                          H  H  -- -- -- --   --  --  CH.sub.3                                                                           CH.sub.2 CF.sub.3                                                                   --                      A-6                                                                               Q-1                                                                               0  H  H  -- H  H  H  H  -- --   --  --  --  --   CH.sub.3                __________________________________________________________________________                                                                 m.p.                                        A  Q  n R R.sub.1                                                                          R.sub.7                                                                          R.sub.8                                                                          R.sub.9                                                                          R.sub.10                                                                          R.sub.11                                                                          X.sub.4                                                                            Y.sub.4                                                                            Z  (°C.)       __________________________________________________________________________                              A-7                                                                               Q-1                                                                               0 H H H H H H  -- CH.sub.3                                                                           CH.sub.3                                                                           CH                                             A-7                                                                               Q-1                                                                               0 H H H H H H  -- CH.sub.3                                                                           OCH.sub.3                                                                          N                                              A-7                                                                               Q-2                                                                               0 H H H H --                                                                               -- H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                             A-7                                                                               Q-2                                                                               0 H H H H --                                                                               -- H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                              A-7                                                                               Q-4                                                                               0 H H H H --                                                                               -- -- OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                             A-7                                                                               Q-4                                                                               0 H H H H --                                                                               -- -- CH.sub.3                                                                           CH.sub.3                                                                           N                     __________________________________________________________________________

                                      TABLE IV                                     __________________________________________________________________________     General Structure IV                                                                                                                      m.p.                L  Q  A  R.sub.1                                                                           R.sub.2                                                                           R.sub.3                                                                           R.sub.7                                                                           R.sub.8                                                                           R.sub.9                                                                           R.sub.10                                                                          R.sub.11                                                                           X.sub.1                                                                              Y.sub.1                                                                           Y.sub.2                                                                            X.sub.2                                                                            Y.sub.3                                                                            X.sub.3                                                                            (°C.)        __________________________________________________________________________     L-2                                                                               Q-1                                                                               A-2                                                                               H  -- -- H  H  H  H  --  CH.sub.3                                                                             O  --  --  --  --                      L-2                                                                               Q-6                                                                               A-4                                                                               H  -- -- H  Cl -- -- --  OCH.sub.3                                                                            -- H   --  --  --                      L-2                                                                               Q-10                                                                              A-5                                                                               H  -- CH.sub.3                                                                          H  H  -- -- --  --    -- --  OCH.sub.3                                                                          CH.sub.3                                                                           --                      L-3                                                                               Q-1                                                                               A-3                                                                               H  CH.sub.3                                                                          -- H  H  H  H  --  OCH.sub.3                                                                            -- --  --  --  --                      L-3                                                                               Q-1                                                                               A-6                                                                               H  CH.sub.3                                                                          -- Cl H  H  H  --  --    -- --  --  --  OCH.sub.3               L-3                                                                               Q-3                                                                               A-2                                                                               H  CH.sub.3                                                                          CH.sub.3                                                                          H  H  -- -- H   OCH.sub.3                                                                            CH.sub.2                                                                          --  --  --  --                      L-4                                                                               Q-1                                                                               A-3                                                                               H  -- -- H  H  H  H  --  OCH.sub.3                                                                            -- --  --  --  --                      L-4                                                                               Q-1                                                                               A-4                                                                               H  -- -- H  F  H  H  --  OCH.sub.3                                                                            -- CH.sub.3                                                                           --  --  --                      L-4                                                                               Q-2                                                                               A-2                                                                               H  -- -- H  CH.sub.3                                                                          -- -- H   OCF.sub.2 H                                                                          O  --  --  --  --                      L-4                                                                               Q-3                                                                               A-4                                                                               H  -- CH.sub.3                                                                          H  H  -- -- H   CH.sub.3                                                                             -- CH.sub.3                                                                           --  --  --                      L-5                                                                               Q-1                                                                               A-2                                                                               H  -- -- H  H  H  H  --  OCH.sub.2 CH.sub.3                                                                   CH.sub.2                                                                          --  --  --  --                      L-5                                                                               Q-1                                                                               A-6                                                                               H  -- -- H  Cl H  H  --  --    -- --  --  --  CH.sub.3                L-5                                                                               Q-4                                                                               A-2                                                                               H  -- -- H  H  -- -- --  OCH.sub.3                                                                            O  --  --  --  --                      L-5                                                                               Q-7                                                                               A-5                                                                               H  -- -- H  H  -- -- --  --    -- --  SCH.sub.3                                                                          CH.sub.3                                                                           --                      L-6                                                                               Q-1                                                                               A-2                                                                               H  -- -- H  H  H  H  --  CH.sub.3                                                                             O  --  --  --  --                      L-6                                                                               Q-5                                                                               A-2                                                                               H  -- -- H  CH.sub.3                                                                          -- -- --  CH.sub.3                                                                             CH.sub.2                                                                          --  --  --  --                      L-6                                                                               Q-8                                                                               A-6                                                                               H  -- -- H  H  -- -- --  --    -- --  --  --  OCH.sub.3               L-6                                                                               Q-9                                                                               A-2                                                                               H  -- CH.sub.3                                                                          H  H  -- -- --  OCH.sub.3                                                                            O  --  --  --  --                      L-2                                                                               Q-1                                                                               A-2                                                                               H  -- -- H  OH -- -- --  OCH.sub.3                                                                            O  --  --  --  --                      __________________________________________________________________________

                                      TABLE V                                      __________________________________________________________________________     General Structure V (where R.sub.9 and R.sub.10 are a carbonyl group)          L  Q  R  R.sub.1                                                                          R.sub.2                                                                           R.sub.7                                                                          R.sub.8                                                                               X   Y   Z  m.p. (°C.)                            __________________________________________________________________________     L-1                                                                               Q-1                                                                               H  H -- H H      CH.sub.3                                                                           CH.sub.3                                                                           CH                                              L-1                                                                               Q-1                                                                               H  H -- H H      OCH.sub.3                                                                          CH.sub.3                                                                           CH                                              L-1                                                                               Q-1                                                                               H  H -- H H      OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                              L-1                                                                               Q-1                                                                               H  H -- H H      CH.sub.3                                                                           CH.sub.3                                                                           N                                               L-1                                                                               Q-1                                                                               H  H -- H H      OCH.sub.3                                                                          CH.sub.3                                                                           N                                               L-1                                                                               Q-1                                                                               H  H -- H H      OCH.sub.3                                                                          OCH.sub.3                                                                          N                                               L-1                                                                               Q-1                                                                               H  H -- H Cl     CH.sub.3                                                                           OCH.sub.3                                                                          CH                                              L-1                                                                               Q-1                                                                               H  H -- H F      CH.sub.3                                                                           OCH.sub.3                                                                          N                                               L-1                                                                               Q-1                                                                               H  H -- H Br     OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                              L-1                                                                               Q-1                                                                               H  H -- H CN     OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                              L-1                                                                               Q-1                                                                               H  H -- H CH.sub.3                                                                              CH.sub.3                                                                           OCH.sub.3                                                                          N                                               L-1                                                                               Q-1                                                                               H  H -- H OCH.sub.3                                                                             CH.sub.3                                                                           CH.sub.3                                                                           CH                                              L-1                                                                               Q-1                                                                               H  H -- H CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                          OCH.sub.3                                                                          N                                               L-1                                                                               Q-1                                                                               H  H -- H SO.sub.2 N(CH.sub.3).sub.2                                                            CH.sub.3                                                                           OCH.sub.3                                                                          CH                                              L-1                                                                               Q-1                                                                               H  H -- H SCH.sub.3                                                                             CH.sub.3                                                                           OCH.sub.3                                                                          CH                                              L-1                                                                               Q-1                                                                               H  H -- H SO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                           CH.sub.3                                                                           N                                               L-1                                                                               Q-1                                                                               CH.sub.3                                                                          H -- H H      OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                              L-2                                                                               Q-1                                                                               H  H -- H H      CH.sub.3                                                                           OCH.sub.3                                                                          CH                                              L-2                                                                               Q-1                                                                               H  H -- H H      OCH.sub.3                                                                          OCH.sub.3                                                                          N                                               L-3                                                                               Q-1                                                                               H  H CH.sub.3                                                                          H H      OCH.sub.3                                                                          CH.sub.3                                                                           CH                                              L-3                                                                               Q-1                                                                               H  H CH.sub.3                                                                          H H      OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                              L-4                                                                               Q-1                                                                               H  H -- H H      CH.sub.3                                                                           OCH.sub.3                                                                          N                                               L-4                                                                               Q-1                                                                               H  H -- H CH.sub.3                                                                              CH.sub.3                                                                           OCH.sub.3                                                                          CH                                              L-5                                                                               Q-1                                                                               H  H -- H H      OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                              L-5                                                                               Q-1                                                                               H  H -- H Cl     CH.sub.3                                                                           CH.sub.3                                                                           CH                                              L-6                                                                               Q-1                                                                               H  H -- H H      OCH.sub.3                                                                          OCH.sub.3                                                                          N                                               L-6                                                                               Q-1                                                                               H  H -- H H      CH.sub.3                                                                           CH.sub.3                                                                           N                                               L-6                                                                               Q-1                                                                               H  H -- Cl                                                                               Cl     OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                              __________________________________________________________________________

Formulations

Useful formulations of the compounds of Formula I can be prepared in conventional ways. They include dusts, granules, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates and the like. Many of these may be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from a few liters to several hundred liters per hectare. High strength compositions are primarily used as intermediates for further formulation. The formulations, broadly, contain about 0.1% to 99% by weight of active ingredient(s) and at least one of (a) about 0.1% to 20% surfactant(s) and (b) about 1% to 99.9% solid or liquid inert diluent(s). More specifically,they will contain these ingredients in the following approximate proportions:

    ______________________________________                                                     Active  Weight Percent*                                                        Ingredient                                                                             Diluent(s)                                                                               Surfactant(s)                                    ______________________________________                                         Wettable Powders                                                                             20-90     0-74      1-10                                         Oil Suspensions.                                                                             3-50      40-95     0-15                                         Emulsions. Solutions.                                                          (including Emulsifiable                                                        Concentrates)                                                                  Aqueous Suspension                                                                           10-50     40-84     1-20                                         Dusts         1-25      70-99     0-5                                          Granules and Pellets                                                                         0.1-95    5-99.9    0-15                                         High Strength 90-99     0-10      0-2                                          Compositions                                                                   ______________________________________                                         *Active ingredient plus at least one of a Surfactant or a Diluent equals        100 weiqht percent.                                                      

Lower or higher levels of active ingredient can, of course, be present depending on the intended use and the physical properties of the compound.Higher ratios of surfactant to active ingredient are sometimes desirable, and are achieved by incorporation into the formulation or by tank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books, Caldwell,N.J., but other solids, either mined or manufactured, may be used. The moreabsorptive diluents are preferred for wettable powders and the denser ones for dusts. Typical liquid diluents and solvents are described in Marsden, "Solvents Guide", 2nd Ed., Interscience, N.Y., 1950. Solubility under 0.1%is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at 0° C. "McCutcheon's Detergents and Emulsifiers Annual", MC publishing Corp., Ridgewood, N.J., as well as Sisely and Wood, "Encyclopedia of Surface Active Agents", Chemical Publishing Co., Inc., N.Y., 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foaming, caking, corrosion, microbiological growth, etc.

The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, Littler. U.S. Pat. No. 3,060,084). Granules and pellets may be made by spraying theactive material upon preformed granular carriers or by agglomeration techniques. See J. E. Browning, "Agglomeration", Chemical Engineering, Dec. 4, 1967, pp. 147ff. and "Perry's Chemical Engineer's Handbook", 5th Ed., McGraw-Hill, N.Y., 1973, pp. 8-57ff.

For further information regarding the art of formulation, see for example:

H. M. Loux, U.S. Pat. No. 3,235,361, Feb. 15, 1966, Col. 6, line 16 throughCol. 7, line 19 and Examples 10 through 41;

R. W. Luckenbaugh, U.S. Pat. No. 3,309,192, Mar. 14, 1967, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182;

H. Gysin and E. Knusli, U.S. Pat. No. 2,891,855, June 23, 1959, Col. 3. line 66 through Col. 5, line 17 and Examples 1-4;

G. C. Klingman, "Weed Control as a Science", John Wiley and Sons, Inc., NewYork, 1961, pp. 81-96; and

J. D. Fryer and S. A. Evans, "Weed Control Handbook", 5th Ed., Blackwell Scientific Publications, Oxford, 1968, pp. 101-103.

In the following examples, all parts are by weight unless otherwise indicated.

EXAMPLE 8

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-                               2-(2-oxiranylmethyl)benzenesulfonamide                                                                     50%                                                sodium alkylnaphthalenesulfonate                                                                           2%                                                 low viscosity methyl cellulose                                                                             2%                                                 diatomaceous earth          46%                                                ______________________________________                                    

The ingredients are blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in diameter. The product is reblended before packaging.

EXAMPLE 9

    ______________________________________                                         Granule                                                                        ______________________________________                                         Wettable Powder of Example 8                                                                             5%                                                   attapulgite granules      95%                                                  (U.S.S. 20-40 mesh; 0.84-0.42 mm)                                              ______________________________________                                    

A slurry of wettable powder containing 25% solids is sprayed on the surfaceof attapulgite granules in a double-cone blender. The granules are dried and packaged.

EXAMPLE 10

    ______________________________________                                         Extruded pellet                                                                ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-                               2-(2-oxiranylmethyl)benzenesulfonamide                                                                     25%                                                anhydrous sodium sulfate    10%                                                crude calcium ligninsulfonate                                                                              5%                                                 sodium alkylnaphthalenesulfonate                                                                           1%                                                 calcium/magnesium bentonite 59%                                                ______________________________________                                    

The ingredients are blended, hammer-milled and then moistened with about 12% water. The mixture is extruded as cylinders about 3 mm diameter which are cut to produce pellets about 3 mm long. These may be used directly after drying, or the dried pellets may be crushed to pass a U.S.S. No. 20 sieve (0.84 mm openings). The granules held on a U.S.S. No. 40 sieve (0.42mm openings) may be packaged for use and the fines recycled.

EXAMPLE 11

    ______________________________________                                         Low Strength Granule                                                           ______________________________________                                         2-(2,2-dichlorocyclopropyl)-N--[(4-methoxy-6-methyl)-                          aminocarbonyl]benzenesulfonamide                                                                            1%                                                N,N--dimethylformamide       9%                                                attapulgite granules         90%                                               (U.S.S. 20-40 sieve)                                                           ______________________________________                                    

The active ingredient is dissolved in the solvent and the solution is sprayed upon dedusted granules in a double cone blender. After spraying ofthe solution has been completed, the blender is allowed to run for a short period and then the granules are packaged.

EXAMPLE 12

    ______________________________________                                         Aqueous Suspension                                                             ______________________________________                                         2-(2,2-dichlorocyclopropyl)-N--[(4-methoxy-6-methyl)-                          aminocarbonyl]benzenesulfonamide                                                                           40%                                                polyacrylic acid thickener  0.3%                                               dodecylphenol polyethylene glycol ether                                                                    0.5%                                               disodium phosphate          1%                                                 monosodium phosphate        0.5%                                               polyvinyl alcohol           1.0%                                               water                       56.7%                                              ______________________________________                                    

The ingredients are blended and ground together in a sand mill to produce particles essentially all under 5 microns in size.

EXAMPLE 13

    ______________________________________                                         Oil Suspension                                                                 ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-                               2-(2-oxiranylmethyl)benzenesulfonamide                                                                     35%                                                blend of polyalcohol carboxylic                                                                            6%                                                 esters and oil soluble petroleum                                               sulfonates                                                                     xylene                      59%                                                ______________________________________                                    

The ingredients are combined and ground together in a sand mill to produce particles essentially all below 5 microns. The product can be used directly, extended with oils, or emulsified in water.

EXAMPLE 14

    ______________________________________                                         Granule                                                                        ______________________________________                                         2-(2,2-dichlorocyclopropyl)-N--[(4,6-dimethoxypyrimidin-                       2-yl)aminocarbonyl]benzenesulfonamide                                                                       80%                                               wetting agent                1%                                                crude ligninsulfonate salt (containing                                                                      10%                                               5-20% of the natural sugars)                                                   attapulgite clay             9%                                                ______________________________________                                    

The ingredients are blended and milled to pass through a 100 mesh screen. This material is then added to a fluid bed granulator, the air flow is adjusted to gently fluidize the material, and a fine spray of water is sprayed onto the fluidized material. The fluidization and spraying are continued until granules of the desired size range are made. The spraying is stopped, but fluidization is continued, optionally with heat, until thewater content is reduced to the desired level, generally less than 1%. The material is then discharged, screened to the desired size range. generally14-100 mesh (1410-149 microns), and packaged for use.

EXAMPLE 15

    ______________________________________                                         High Strength Concentrate                                                      ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-                               2-(2-oxiranylmethyl)benzenesulfonamide                                                                      99%                                               silica aerogel               0.5%                                              synthetic amorphous silica   0.5%                                              ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produce a material essentially all passing a U.S.S. No. 50 screen (0.3 mm opening). The concentrate may be formulated further if necessary.

EXAMPLE 16

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         2-(2,2-dichlorocyclopropyl)-N--[(4-methoxy-6-methyl)-                          aminocarbonyl]benzenesulfonamide                                                                           90%                                                dioctyl sodium sulfosuccinate                                                                              0.1%                                               synthetic fine silica       9.9%                                               ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produce particles essentially all below 100 microns. The material is sifted through a U.S.S. No. 50 screen and then packaged.

EXAMPLE 17

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         2-(2,2-dichlorocyclopropyl)-N--[(4,6-dimethoxypyrimidin-                       2-yl)aminocarbonyl]benzenesulfonamide                                                                       40%                                               sodium ligninsulfonate       20%                                               montmorillonite clay         40%                                               ______________________________________                                    

The ingredients are thoroughly blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in size. The material is reblended and then packaged.

EXAMPLE 18

    ______________________________________                                         Dust                                                                           ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-                               2-(2-oxiranylmethyl)benzenesulfonamide                                                                      10%                                               attapulgite                  10%                                               Pyrophyllite                 80%                                               ______________________________________                                    

The active ingredient is blended with attapulgite and then passed through ahammer-mill to produce particles substantially all below 200 microns. The ground concentrate is then blended with powdered pyrophyllite until homogeneous.

Utility

Test results indicate that the compounds of the present invention are highly active preemergent or postemergent herbicides or plant growth regulants. Many of them have utility for broad-spectrum pre- and or post-emergence weed control in areas where complete control of all vegetation is desired, such as around fuel storage tanks, ammunition depots, industrial storage areas, parking lots, drive-in theaters, around billboards, highway and railroad structures. Some of the compounds have utility for selective weed control in crops such as rice and wheat. Alternatively, the subject compounds are useful to modify plant growth.

The rates of application for the compounds of the invention are determined by a number of factors, including their use as plant growth modifiers or as herbicides, the crop species involved, the types of weeds to be controlled, weather and climate, formulations selected, mode of application, amount of foliage present, etc. In general terms, the subjectcompounds should be applied at levels of around 0.05 to 10 kg/ha, the lowerrates being suggested for use on lighter soils and/or those having a low organic matter content, for plant growth modification or for situations where only short-term persistence is required.

The compounds of the invention may be used in combination with any other commercial herbicide, examples of which are those of the triazine, triazole, uracil, urea, amide, diphenylether, carbamate and bipyridylium types.

The herbicidal properties of the subject compounds were discovered in a number of greenhouse tests. The test procedures and results follow.

Test A

Seeds of crabgrass (Digitaria sp.). barnyard-grass (Echinochloa crusgalli),wild oats (Avena fatua), cheatgrass (Bromus secalinus), velvetleaf (Abutilon theophrasti), sicklepod (Cassia obtusifolia), morning-glory (Ipomoea sp.), cocklebur (Xanthium sp.), sorghum, corn, soybean, rice, wheat and nutsedge tubers (Cyperus rotundus) were planted in a growth medium and treated pre-emergence with the chemicals dissolved in a nonphytotoxic solvent. At the same time, cotton having five leaves (including cotyledonary ones), bush beans with the third trifoliate leaf expanding, crabgrass, barnyardgrass and wild oats with two leaves, sickle-pod with three leaves (including cotyledonary ones), morningglory and cocklebur with four leaves (including the cotyledonary ones), sorghum and corn with four leaves, soybean with two cotyledonary leaves, rice withthree leaves, wheat with one leaf, and nutsedge with three to five leaves were sprayed. Treated plants and controls were maintained in a greenhouse for sixteen days, whereupon all species were compared to controls and visually rated for response to treatment. The ratings are based on a numerical scale extending from 0 =no injury, to 10 =complete kill. The accompanying descriptive symbols have the following meanings:

C=chlorosis or necrosis;

B=burn;

D=defoliation;

E=emergence inhibition;

G=growth retardation;

H=formative effects;

U=unusual pigmentation

X=axillary stimulation;

S=albinism; and

6Y=absoised buds or flowers.

Compounds

    ______________________________________                                          ##STR52##                                                                     Compound n     O            X     Y       Z                                    ______________________________________                                         1        0     2,2-dichloro-                                                                               CH.sub.3                                                                             CH.sub.3                                                                               CH                                                  cyclopropyl                                                     2        0     2,2-dichloro-                                                                               CH.sub.3                                                                             OCH.sub.3                                                                              CH                                                  cyclopropyl                                                     3        0     2,2-dichloro-                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                                  cyclopropyl                                                     4        0     2,2-dichloro-                                                                               CH.sub.3                                                                             CH.sub.3                                                                               N                                                   cyclopropyl                                                     5        0     2,2-dichloro-                                                                               CH.sub.3                                                                             OCH.sub.3                                                                              N                                                   cyclopropyl                                                     6        0     2,2-dichloro-                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                              N                                                   cyclopropyl                                                     7        1                                                                                     ##STR53##   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                   8        0                                                                                     ##STR54##   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                   9        0                                                                                     ##STR55##   CH.sub.3                                                                             CH.sub.3                                                                               CH                                   ______________________________________                                    

                  TABLE A                                                          ______________________________________                                                      Compound   Compound  Compound                                                  1          2         3                                            ______________________________________                                         Rate (kg/ha) 0.05       0.05      0.05                                         POSTEMERGENCE                                                                  Morningglory 0          2C,5G     5C,8G                                        Cocklebur    5G         9C        9C                                           Velvetleaf   2C,8G      9C        10C                                          Nutsedge     0          10C       9C                                           Crabgrass    0          2G        4G                                           Barnyardgrass                                                                               0          8H        3H                                           Cheatgrass   0          2C,6G     2C,6G                                        Wild Oats    0          2G        0                                            Wheat        0          0         0                                            Corn         0          2C,8H     1C,4G                                        Soybean      2C,9G      4C,9G     5C,9G                                        Rice         5G         2C,7G     2C,6G                                        Sorghum      2H         2G        2G                                           Sugar Beets  0          5G        4C,8G                                        Cotton       4C,8H      5C,9G     5C,9G                                        PREEMERGENCE                                                                   Morningglory 4G         8G        7G                                           Cocklebur    --         8H        9G                                           Velvetleaf   2G         9G        9G                                           Nutsedge     0          9G        10E                                          Crabgrass    0          2G        2C,8G                                        Barnyardgrass                                                                               0          2C,9H     2C,7H                                        Cheatgrass   2G         5C,9H     5C,9H                                        Wild Oats    0          3C,8G     3G                                           Wheat        0          6G        2G                                           Corn         2G         2C,9H     2C,8G                                        Soybean      0          4C,8H     7G                                           Rice         3G         4C,8G     2C,8H                                        Sorghum      5G         4C,8H     2C,7H                                        Sugar Beets  5G         8G        9G                                           Cotton       5G         9G        8G                                                        Compound   Compound  Compound                                                  4          5         6                                            ______________________________________                                         Rate (kg/ha) 0.05       0.05      0.05                                         POSTEMERGENCE                                                                  Morningglory 4C,8G      10C       10C                                          Cocklebur    3C,8G      9C        10C                                          Velvetleaf   4C,8H      10C       10C                                          Nutsedge     0          9C        9C                                           Crabgrass    0          2G        0                                            Barnyardgrass                                                                               0          2H        0                                            Cheatgrass   0          2C        1C                                           Wild Oats    0          0         0                                            Wheat        0          3G        0                                            Corn         0          3C,8H     3C,8H                                        Soybean      2C,9G      3C,9G     4C,9G                                        Rice         3G         5G        3G                                           Sorghum      0          2C,5H     2C,5H                                        Sugar Beets  5C,9G      9C        10C                                          Cotton       4C,8H      5C,9G     9C                                           PREEMERGENCE                                                                   Morningglory 7H         9G        8G                                           Cocklebur    2C         9H        9C                                           Velvetleaf   0          9G        5C,9G                                        Nutsedge     0          4G        7G                                           Crabgrass    0          0         0                                            Barnyardgrass                                                                               0          2C,3H     2C                                           Cheatgrass   0          5G        0                                            Wild Oats    0          2G        0                                            Wheat        0          0         0                                            Corn         2G         4G        2C,6G                                        Soybean      3C,2H      4C,8H     3C,8H                                        Rice         0          4G        3G                                           Sorghum      0          2C,5G     2G                                           Sugar Beets  3C,5G      10E       5C,9G                                        Cotton       5G         9G        9G                                                        Compound   Compound  Compound                                                  7          8         9                                            ______________________________________                                         Rate (kg/ha) 0.05       0.05      0.05                                         POSTEMERGENCE                                                                  Morningglory 2C,8G      1C        0                                            Cocklebur    8H         2C,7G     2G                                           Velvetleaf   --         9C        2G                                           Nutsedge     10C        4C,9G     1C                                           Crabgrass    1C,5G      1C        0                                            Barnyardgrass                                                                               5C,9H      4C,9H     2C,4H                                        Cheatgrass   --         3G        0                                            Wild Oats    2G         0         0                                            Wheat        2G         0         0                                            Corn         2C,8H      2C,7H     2C,5G                                        Soybean      4C,8H      3C,9G,7X  2C,2H                                        Rice         4C,9G      6G        3G                                           Sorghum      2C,9H      2C,7H     2C,5G                                        Sugar Beets  9C         9C        2C,5G                                        Cotton       4C,4H      9C        1H                                           Bushbean     5C,9G      --        --                                           Cassia       2C,9G      --        --                                           PREEMERGENCE                                                                   Morningglory 7G         5G        0                                            Cocklebur    9H         0         0                                            Velvetleaf   --         0         0                                            Nutsedge     5G         0         0                                            Crabgrass    2C         0         0                                            Barnyardgrass                                                                               4C,8H      0         0                                            Cheatgrass   --         0         0                                            Wild Oats    3C,6G      0         0                                            Wheat        1C,3G      0         0                                            Corn         2C,8H      0         1H                                           Soybean      2C,8H      2C        1H                                           Rice         3C,8G      0         4G                                           Sorghum      3C,9G      1C        2G                                           Sugar Beets  9G         6G        2H                                           Cotton       --         2G        0                                            Bushbean     --         --        --                                           Cassia       5C,9H      --        --                                           ______________________________________                                     

What is claimed is:
 1. A compound of the formula ##STR56## wherein W is O;R is H or CH₃ ; L is ##STR57## n is O or 1: R₁ is H, C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, halogen, nitro, CN, C₁ -C₃ alkoxy, SO₂ NR^(I) R^(II), C₁ -C₃ alkylthio, C₁ -C₃ alkylsulfinyl, C₁ -C₃ alkysulfonyl, CO₂ R^(III), CH₂ CN, CH₂ OCH₃ or CH₂ SCH₃ : R^(I) is H, C₁ -C₄ alkyl, C₂ -C₃ cyanoalkyl, methoxy or ethoxy: R^(II) is H, C₁ -C₄ alkyl or C₃ -C₄ alkenyl: or R^(I) and R^(II) may be taken together as --(CH₂)₃ --, --(CH₂)₄₋₋, --(CH₂)₅ --or --CH₂ CH₂ OCH₂ CH₂ --: R^(III) is C₁ -C₄ alkyl, C₃ -C₄ alkenyl, C₃ -C₄ alkynyl, C₂ -C₄ haloalkyl, C₂ -C₃ cyanoalkyl, C₅ -C₆ cycloalkyl, C₄ -C₇ cycloalkylalkyl or C₂ -C₄ alkoxyalkyl; R₂ is C₁ -C₃ alkyl: Q is a 3- or 4-membered heterocyclic ring which contains one heteroatom selected from O, S and NR₃, or a 3- or 4-membered carbocyclic ring in which one carbon atom may optionally be in the form of a carbonyl group, or a fully-saturated 5- or 6-membered carbocyclic ring, and Q may be optionally substituted with 1-4 substituents selected from halogen, CN, OH, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, C₁ -C₃ alkylthio, C₂ -C₄ alkoxycarbony, C₁ -C₄ alkylsulfony, (C₁ -C₄ alkyl) -aminosulfamoyl and di(C₁ -C₄ alkyl)aminosulfamoyl; R₃ is C₁ -C₄ alkyl; R₁₂ is H or OR₁₄ ; R₁₃ is H or C₁ -C₄ alkyl; R₁₄ is H, C₁ -C₄ alkyl, C₃ -C₄ alkenyl, C₃ -C₄ haloalkenyl, C₃ -C₄ alkynyl, C₃ -C₄ haloalkynyl, C₂ -C₄ alkylcarbonyl, C(O)NR₁₅ R₁₆, C₁ -C₄ alkylsulfonyl, C₂ -C₄ alkoxyalkyl or C₂ -C₄ alkylthioalkyl; R₁₅ and R₁₆ are independently H or C₁ -C₂ alkyl; A is ##STR58## Y₁ is O or CH₂ ; X₁ is CH₃, OCH₃, OC₂ H₅ or OCF₂ H; and Y₂ is H or CH₃ ; and their agriculturally suitable salts; provided that(a) when L is L-2 or L-3, then the Q substituent and the sulfonylurea bridge are on adjacent carbon atoms; and (b) the total number of carbon atoms of R₁₂ and R₁₃ must be less than or equal to four.
 2. The compounds of claim 1 where Q is ##STR59## wherein R₃ is C₁ -C₃ alkyl;R₇ is H, F, Cl, Br, CN, CH₃ or OCH₃ ; R₈ is H, F, Cl, Br, I, CN, OH, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, C₂ -C₃ alkoxycarbonyl, di(C₁ -C₃ alkyl)amino sulfamoyl, C₁ -C₃ alkylthio or C₁ -C₃ alkylsulfonyl; R₉ and R₁₀ are independently H, CH₃, F, Cl or may be taken toqether to form C═O; and R₁₁ is H or C₁ -C₃ alkyl; provided that(a) when R₇ and R₈ are attached to the same carbon atom as in Q-1, Q2 or Q-3, or in Q-4 through Q-10, and R₇ is OCH₃ then R₈ is other than F, Cl, Br, I or OH; and (b) when R₇ and R₈ are attached to the same carbon atom as in Q-1, Q-2 or Q-3, or in Q-4 through Q-10, and R₈ is F, Cl, Br, I or OH, then R₇ is other than OCH₃.
 3. An agriculturally suitable composition for controlling the growth of undesired vegetation which comprises an effective amount of a compound of claim 1 and at least one of the following: surfactant, solid or liquid diluent.
 4. An agriculturally suitable composition for controlling the growth of undesired vegetation which comprises an effective amount of a compound of claim 2 and at least one of the following: surfactant, solid or liquid diluent.
 5. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 1. 6. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 2. 